Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Claudia Grossmann"'
Publikováno v:
Cells, Vol 12, Iss 18, p 2269 (2023)
Calcineurin, a serine/threonine phosphatase regulating transcription factors like NFaT and CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy. Results from experiments with calcineurin knockout animals and calcineur
Externí odkaz:
https://doaj.org/article/2429f4efd9414259847752b76bb78f53
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Background Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance of calcium homeostasis can have detrimental effects on cardiac function. While it
Externí odkaz:
https://doaj.org/article/78d3075246294c98ab957cbd4f148eb3
Autor:
Katharina Stroedecke, Sandra Meinel, Fritz Markwardt, Udo Kloeckner, Nicole Straetz, Katja Quarch, Barbara Schreier, Michael Kopf, Michael Gekle, Claudia Grossmann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The EGF receptor (EGFR) has been extensively studied in tumor biology and recently a role in cardiovascular pathophysiology was suggested. The mineralocorticoid receptor (MR) is an important effector of the renin–angiotensin–aldosterone-
Externí odkaz:
https://doaj.org/article/e7c08a9ce14145d4984ef05ebc288861
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
During aging, the cardiovascular system is especially prone to a decline in function and to life-expectancy limiting diseases. Cardiovascular aging is associated with increased arterial stiffness and vasoconstriction as well as left ventricular hyper
Externí odkaz:
https://doaj.org/article/005d710b93674fcb959b04301faebe3d
Autor:
Julia Hupfeld, Maximilian Ernst, Maria Knyrim, Stephanie Binas, Udo Kloeckner, Sindy Rabe, Katja Quarch, Danny Misiak, Matthew Fuszard, Claudia Grossmann, Michael Gekle, Barbara Schreier
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 719 (2021)
MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among them cardiac hypertrophy and atrial fibrillation. Cardiac miR expression was analyzed in a mouse model with structural and electrical remodeling. Next-generation sequ
Externí odkaz:
https://doaj.org/article/5789de281c084aa7ac2f8d900502e997
Autor:
Ulrich Gergs, Tina Jahn, Franziska Werner, Carolin Köhler, Friedrich Köpp, Claudia Großmann, Joachim Neumann
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221289 (2019)
The pathophysiological mechanisms of sepsis-induced cardiac dysfunction are largely unknown. The Toll-like receptor 4 (TLR4) is expressed in cardiac myocytes and is involved in bacterial endotoxin-mediated inflammatory disorders. TLR4 signaling leads
Externí odkaz:
https://doaj.org/article/06094ab40c4040069fc5b27deb5ac80e
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1266 (2007)
BackgroundForthright reporting of financial ties and conflicts of interest of researchers is associated with public trust in and esteem for the scientific enterprise.Methods/principal findingsWe searched Lexis/Nexis Academic News for the top news sto
Externí odkaz:
https://doaj.org/article/841bd0df021c4eb58d3b9195fb748656
Autor:
Institute of Medicine, Roundtable on Value and Science-Driven Health Care, Julia Sanders, Brian Powers, Claudia Grossmann
Digital health data are the lifeblood of a continuous learning health system. A steady flow of reliable data is necessary to coordinate and monitor patient care, analyze and improve systems of care, conduct research to develop new products and approa
Autor:
Institute of Medicine, Roundtable on Value and Science-Driven Health Care, J. Michael McGinnis, Brian Powers, Claudia Grossmann
Like many other industries, health care is increasingly turning to digital information and the use of electronic resources. The Institute of Medicine's Roundtable on Value & Science-Driven Health Care hosted three workshops to explore current efforts
Autor:
Institute of Medicine, Roundtable on Value and Science-Driven Health Care, J. Michael McGinnis, LeighAnne Olsen, W. Alexander Goolsby, Claudia Grossmann
Successful development of clinical data as an engine for knowledge generation has the potential to transform health and health care in America. As part of its Learning Health System Series, the Roundtable on Value & Science-Driven Health Care hosted