Contribution of pilus type 2b to invasive disease caused by a Streptococcus agalactiae ST-17 strain

Autor: Maddalena Lazzarin, Rong Mu, Monica Fabbrini, Claudia Ghezzo, C. Daniela Rinaudo, Kelly S. Doran, Immaculada Margarit

Publikováno v: BMC Microbiology, Vol 17, Iss 1, Pp 1-8 (2017)

Abstract Background Group B Streptococcus (GBS) is a major cause of invasive disease especially in neonates. In GBS three structurally distinct pilus polymers have been identified as important virulence factors and promising vaccine candidates. The v

Externí odkaz: https://doaj.org/article/00406340d30f47be98866854754c3788

Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus.

Autor: Cira Daniela Rinaudo, Roberto Rosini, Cesira L Galeotti, Francesco Berti, Francesca Necchi, Valerio Reguzzi, Claudia Ghezzo, John Laird Telford, Guido Grandi, Domenico Maione

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9216 (2010)

Streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis. Persistent colonization usually involves the formation of biofilm

Externí odkaz: https://doaj.org/article/8b8dec01152c4b3592d8c0fef708c9cf

Capturing host‐pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP

Autor: Pietro Speziale, Simonetta Rindi, Giampiero Pietrocola, Immaculada Margarit, Mauro Bombaci, Renata Grifantini, Vincenzo Nardi-Dei, Claudia Ghezzo, Stefano Bonacci, Guido Grandi

Publikováno v: The FASEB Journal. 23:3100-3112

Microbial pathogen entry and survival in the host is mediated by a network of molecular interactions between the two partners, which has been the subject of many research efforts. A complex picture is emerging in which host-pathogen crosstalk involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2f25a33f2dd853a4a72388dd3111a
https://doi.org/10.1096/fj.09-131458

Emergence and Global Dissemination of Host-Specific Streptococcus agalactiae Clones

Autor: Knud Poulsen, Mogens Kilian, Uffe B. Skov Sørensen, Immaculada Margarit, Claudia Ghezzo

Publikováno v: mBio, Vol 1, Iss 3 (2010)
mBio
Sørensen, U, Poulsen, K, Ghezzo, C, Margarit, I & Kilian, M 2010, ' Emergence and Global Dissemination of Host-Specific Streptococcus agalactiae Clones ', mBio, vol. 1, no. 3 . https://doi.org/10.1128/mBio.00178-10

To examine the global diversity of Streptococcus agalactiae (group B streptococci [GBS]) and to elucidate the evolutionary processes that determine its population genetics structure and the reported changes in host tropism and infection epidemiology,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eea0447bd422e472cae451f801b14a
https://journals.asm.org/doi/10.1128/mBio.00178-10

Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm

Autor: Alberto Berardi, Guido Grandi, Elena Buttazzoni, Scilla Buccato, Carol J. Baker, Eleonora Tresoldi, Roberta Creti, Cesira Galeotti, Domenico Maione, Cira Daniela Rinaudo, Marirosa Mora, Ylenia Runci, Massimiliano Pagani, John L. Telford, Claudia Ghezzo, Roberto Rosini, Immaculada Margarit

Publikováno v: The Journal of infectious diseases. 199(1)

We recently described the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa45bf8c3d18e9a1f367a8cd2f730b2
https://pubmed.ncbi.nlm.nih.gov/19086816