Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Claudia Göttlich"'
Autor:
Claudia Göttlich, Meik Kunz, Cornelia Zapp, Sarah L. Nietzer, Heike Walles, Thomas Dandekar, Gudrun Dandekar
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1264-1285 (2018)
Patient‐tailored therapy based on tumor drivers is promising for lung cancer treatment. For this, we combined in vitro tissue models with in silico analyses. Using individual cell lines with specific mutations, we demonstrate a generic and rapid st
Externí odkaz:
https://doaj.org/article/86d2ed686265462fa00ea9197977654f
Autor:
Meik Kunz, Claudia Göttlich, Thorsten Walles, Sarah Nietzer, Gudrun Dandekar, Thomas Dandekar
Publikováno v:
Tumor Biology, Vol 39 (2017)
MicroRNAs are well-known strong RNA regulators modulating whole functional units in complex signaling networks. Regarding clinical application, they have potential as biomarkers for prognosis, diagnosis, and therapy. In this review, we focus on two m
Externí odkaz:
https://doaj.org/article/c0b682f0595040adb0a80f7a367c421a
Autor:
Matthias Peindl, Claudia Göttlich, Samantha Crouch, Niklas Hoff, Tamara Lüttgens, Franziska Schmitt, Jesús Guillermo Nieves Pereira, Celina May, Anna Schliermann, Corinna Kronenthaler, Danjouma Cheufou, Simone Reu-Hofer, Andreas Rosenwald, Elena Weigl, Thorsten Walles, Julia Schüler, Thomas Dandekar, Sarah Nietzer, Gudrun Dandekar
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2176
Epithelial-to-mesenchymal transition (EMT) is discussed to be centrally involved in invasion, stemness, and drug resistance. Experimental models to evaluate this process in its biological complexity are limited. To shed light on EMT impact and test d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87e4821864cf729b29d87d6bfc85523
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/27074
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/27074
Autor:
Johanna, Kühnemundt, Heidi, Leifeld, Florian, Scherg, Matthias, Schmitt, Lena C, Nelke, Tina, Schmitt, Florentin, Baur, Claudia, Göttlich, Maximilian, Fuchs, Meik, Kunz, Matthias, Peindl, Caroline, Brähler, Corinna, Kronenthaler, Jörg, Wischhusen, Martina, Prelog, Heike, Walles, Thomas, Dandekar, Gudrun, Dandekar, Sarah L, Nietzer
Publikováno v:
ALTEX. 38(2)
High attrition rates associated with drug testing in 2D cell culture and animal models stress the need for improved modeling of human tumor tissues. In previous studies, our 3D models on a decellularized tissue matrix have shown better predictivity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a29a7beb996750b6589ac521c7b802e
https://pubmed.ncbi.nlm.nih.gov/33313956
https://pubmed.ncbi.nlm.nih.gov/33313956
Autor:
Holger N. Lode, Nikolai Siebert, Claudia Rossig, Kornelius Kerl, Ingo Müller, Claudia Göttlich, Stefanie Lesch, Bianca Altvater, Maike Fluegge, Wolfgang Hartmann, Sonja Schelhaas, Silke Jamitzky, Sebastian T. Balbach, Lea Greune, Heike Walles, Johanna Kühnemundt, Jutta Meltzer, Sareetha Kailayangiri, Jan-Henrik Mikesch, Nicole Farwick
Publikováno v:
Mol Ther
Chimeric antigen receptor (CAR) engineering of T cells allows one to specifically target tumor cells via cell surface antigens. A candidate target in Ewing sarcoma is the ganglioside G(D2), but heterogeneic expression limits its value. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c54360ba8e25b4d1bfedff824acf87
https://europepmc.org/articles/PMC6520468/
https://europepmc.org/articles/PMC6520468/
Publikováno v:
Cancer Research. 80:3041-3041
Three-dimensional (3D) cell culture platforms are increasingly being used in cancer research and drug development. Using patient derived xenograft (PDX) as tumor cell source the clinical relevance of those platforms increases significantly. In combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e02a22b8875fc534dc5157da483b3a
https://doi.org/10.1158/1538-7445.am2020-3041
https://doi.org/10.1158/1538-7445.am2020-3041
Autor:
Gudrun Dandekar, Claudia Göttlich, Thorsten Walles, Sarah Nietzer, Franziska Schmitt, Thomas Dandekar, Meik Kunz, Lena C Müller, Heike Walles
Publikováno v:
Journal of Visualized Experiments.
In the present study, we combined an in vitro 3D lung tumor model with an in silico model to optimize predictions of drug response based on a specific mutational background. The model is generated on a decellularized porcine scaffold that reproduces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac6b140286ee2388902f3c20bb0415a
https://doi.org/10.3791/53885-v
https://doi.org/10.3791/53885-v
Autor:
Martin Kleinschmidt, Jürgen Erich Metzner, Claudia Göttlich, Hans-Ulrich Demuth, Bernd Leplow, Daniel Bittner, Robby Schoenfeld
Background: Current treatment in Alzheimer’s disease (AD) is initiated at a stage where the brain already has irreversible structural deteriorations. Therefore, the concept of treatment prior to obvious cognitive deficits has become widely accepted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa63dca94f390805ba4f153a9ff5a078
https://publica.fraunhofer.de/handle/publica/242721
https://publica.fraunhofer.de/handle/publica/242721
Autor:
Thomas Dandekar, Gudrun Dandekar, Anna T. Stratmann, Thorsten Walles, Heike Walles, Sarah Nietzer, David Fecher, Gaby Wangorsch, Claudia Göttlich
Publikováno v:
Molecular Oncology
For the development of new treatment strategies against cancer, understanding signaling networks and their changes upon drug response is a promising approach to identify new drug targets and biomarker profiles. Pre‐requisites are tumor models with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c734ea5b02654cdf25b1f3d2cea58f8b
https://pubmed.ncbi.nlm.nih.gov/24388494
https://pubmed.ncbi.nlm.nih.gov/24388494