Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Claudia Erpelinck"'
Autor:
Roger Mulet-Lazaro, Stanley van Herk, Margit Nuetzel, Aniko Sijs-Szabo, Noelia Díaz, Katherine Kelly, Claudia Erpelinck-Verschueren, Lucia Schwarzfischer-Pfeilschifter, Hanna Stanewsky, Ute Ackermann, Dagmar Glatz, Johanna Raithel, Alexander Fischer, Sandra Pohl, Anita Rijneveld, Juan M. Vaquerizas, Christian Thiede, Christoph Plass, Bas J. Wouters, Ruud Delwel, Michael Rehli, Claudia Gebhard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phen
Externí odkaz:
https://doaj.org/article/df577d6f414846109f3f3dcf2f2865a4
Autor:
Sophie Ottema, Roger Mulet-Lazaro, Claudia Erpelinck-Verschueren, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H. Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J. Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line an
Externí odkaz:
https://doaj.org/article/7df6196de175464e8b50bb614eba9c97
Autor:
Lars T. van der Veken, Merel C. Maiburg, Floris Groenendaal, Mariëlle E. van Gijn, Andries C. Bloem, Claudia Erpelinck, Stefan Gröschel, Mathijs A. Sanders, Ruud Delwel, Marc B. Bierings, Arjan Buijs
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Externí odkaz:
https://doaj.org/article/dae540236d204d36aa7a857abdb5195d
Autor:
Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel
Publikováno v:
Blood. 140:83-84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b2945a8ac4ef6922144d4ba1a01563
https://doi.org/10.1182/blood-2022-156994
https://doi.org/10.1182/blood-2022-156994
Autor:
Marije Havermans, Eric M.J. Bindels, Leonie Smeenk, Peter J. M. Valk, Stanley van Herk, Claudia Erpelinck, Roger Mulet-Lazaro, H. Berna Beverloo, Ruud Delwel, Robert van der Helm, Sophie Ottema, Torsten Haferlach, Claudia Haferlach, Tim Grob
Publikováno v:
Blood, 136(2), 224-234. American Society of Hematology
Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct World Health Organization recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39746508b6b6cca70aa9cad92ddee879
https://pure.eur.nl/en/publications/acc03a4d-3b41-4de1-bdde-b1ef97734c2f
https://pure.eur.nl/en/publications/acc03a4d-3b41-4de1-bdde-b1ef97734c2f
Autor:
Mathijs A. Sanders, Claudia Erpelinck, Merel C. Maiburg, Marc Bierings, Ruud Delwel, Marielle E. van Gijn, Floris Groenendaal, Andries C. Bloem, Arjan Buijs, Stefan Gröschel, Lars T. van der Veken
Publikováno v:
Haematologica, 103(4), E173-E176. Ferrata Storti Foundation
Haematologica, 103(4), e173. Ferrata Storti Foundation
Haematologica, 103(4), e173. Ferrata Storti Foundation
EVI1 (3q26.2) is a member of the SET/PR domain family of transcription factors and contains two domains of zinc finger (ZF) DNA binding motifs, one at the N-terminus (ZF1) and one at the C-terminus (ZF2), and a C-terminal acidic amino acid cluster do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afcc4ba3c3c899c7cd5cb02a164f576
https://pure.eur.nl/en/publications/58532029-fb62-44c6-a0ef-21d9f7531f25
https://pure.eur.nl/en/publications/58532029-fb62-44c6-a0ef-21d9f7531f25
Autor:
Mathijs A. Sanders, Ivo P. Touw, John E. Pimanda, Hans de Looper, Ruud Delwel, Paulette van Strien, Michael Rehli, Remco Hoogenboezem, Marije Havermans, Thijs Kuiken, Dominik Beck, Roberto Avellino, Stefan Gröschel, Elwin J. C. Rombouts, Claudia Erpelinck, Harmen J.G. van de Werken, Eric M.J. Bindels, Kirsten van Lom, Stefan J. Erkeland, Claudia Gebhard
Publikováno v:
Blood, 127(24), 2991-3003. American Society of Hematology
Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein a (C/EBP alpha), a transcription factor expressed in multiple organs including the bone marrow. Using functional genomic technologies in combination with clustered regularly-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4754573cc16a699dc681fdfede534b
https://doi.org/10.1182/blood-2016-01-695759
https://doi.org/10.1182/blood-2016-01-695759
Autor:
Jan Maarten Cobben, Claudia Erpelinck, Ruud Delwel, Taco W. Kuijpers, Arjan Bouman, Lia Knegt, Mathijs A. Sanders, Stefan Gröschel
Publikováno v:
American Journal of Medical Genetics Part A. 170:504-509
Interstitial deletions encompassing the 3q26.2 region are rare. Only one case-report was published this far describing a patient with an interstitial deletion of 3q26.2 (involving the MDS1-EVI1 complex (MECOM)) and congenital thrombocytopenia. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4e572fa3551e30e544349f8f23c1e6
https://doi.org/10.1002/ajmg.a.37451
https://doi.org/10.1002/ajmg.a.37451
Autor:
John H. Kersey, H. Berna Beverloo, Ruud Delwel, Scott A. Armstrong, Eric M.J. Bindels, Claudia Erpelinck, Hartmut Döhner, Elwin J. C. Rombouts, Sanne Lugthart, Jurgen R. Haanstra, Erdogan Taskesen, Andrei V. Krivtsov, Wendy A. Hudson, Ashish R. Kumar, Elizabeth Wocjtowicz, Marije Havermans
Publikováno v:
Blood, 119(24), 5838-5849. American Society of Hematology
The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements. In the current study, we showed, in a large AML cohort carrying 11q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a63abc29f7a8c4cdd3622db5773d127
https://doi.org/10.1182/blood-2011-11-393827
https://doi.org/10.1182/blood-2011-11-393827
Autor:
Jürgen Krauter, Arnold Ganser, Lars Bullinger, Sonja C P A M van der Poel-van de Luytgaarde, Ruud Delwel, Frederik Damm, Bas J. Wouters, Hartmut Döhner, Andrea Corbacioglu, Bob Löwenberg, Mathijs A. Sanders, Konstanze Döhner, Claudia Erpelinck, Erdogan Taskesen, Richard F. Schlenk, Peter J. M. Valk
Publikováno v:
Blood, 117(8), 2469-2475. American Society of Hematology
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPA(dm)) versus single mutations (CEBPA(sm)) in 1182 cytogenetically normal acute myeloid leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50072b8384e187a4ec1af65e329c1a7c
https://doi.org/10.1182/blood-2010-09-307280
https://doi.org/10.1182/blood-2010-09-307280