Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Claudia Emmerich"'
Autor:
Anja Göder, Claudia Emmerich, Teodora Nikolova, Nicole Kiweler, Maria Schreiber, Toni Kühl, Diana Imhof, Markus Christmann, Thorsten Heinzel, Günter Schneider, Oliver H. Krämer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric ser
Externí odkaz:
https://doaj.org/article/1ced4836ae484e558c659722b88a91e8
Autor:
Claudia Emmerich, Anke Rauch, Thorsten Heinzel, Oliver H. Krämer, Anja Göder, Michael Linnebacher, Al-Hassan M. Mustafa, Annemarie Carlstedt, Shirley K. Knauer
Publikováno v:
Oncotarget
Irinotecan (CPT-11) and oxaliplatin (L-OHP) are among the most frequently used drugs against colorectal tumors. Therefore, it is important to define the molecular mechanisms that these agents modulate in colon cancer cells. Here we demonstrate that C
Autor:
Günter Schneider, Teodora Nikolova, Toni Kühl, Thorsten Heinzel, Markus Christmann, Oliver H. Krämer, Claudia Emmerich, Diana Imhof, Maria Schreiber, Nicole Kiweler, Anja Göder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Checkpoint kinases sense replicative stress to prevent DNA damage. Here we show that the histone deacetylases HDAC1/HDAC2 sustain the phosphorylation of the checkpoint kinases ATM, CHK1 and CHK2, activity of the cell cycle gatekeeper kinases WEE1 and