Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Claudia E. Robert"'
Publikováno v:
Social Science Computer Review. 36:523-541
While emerging technologies such as social media have demonstrated value for crisis communications, significant question remains regarding how these tools can be most effectively leveraged to facilitate the flow of valid information under crisis cond
Autor:
Melanie N. Kuehl, Stanley M. Stevens, Shari L. Moak, Harris Bell-Temin, Brant R. Burkhardt, Grace C. Dougan, Mark G. Athanason, Claudia E. Robert-Cooperman
Publikováno v:
Journal of Endocrinology. 220:219-231
PANcreatic-DERived factor (PANDER, FAM3B) is a novel protein that is highly expressed within the endocrine pancreas and to a lesser degree in other tissues. Under glucose stimulation, PANDER is co-secreted with insulin from the β-cell. Despite prior
Publikováno v:
FEBS Letters. 585:2137-2143
PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-ce
Autor:
Bryan A. Wolf, Jason R. Carnegie, Jianmei Wu, Brant R. Burkhardt, Claudia E. Robert-Cooperman, Robert A. Young
Publikováno v:
Molecular and Cellular Endocrinology. 325:36-45
The novel islet-specific protein PANcreatic DERived Factor (PANDER; FAM3B) has been extensively characterized with respect to the beta-cell, and these studies suggest a potential function for PANDER in the regulation of glucose homeostasis. Little is
Autor:
Zhiyong Gao, Jichun Yang, Jing Li, Claudia E. Robert-Cooperman, Chunjiong Wang, Brant R. Burkhardt, Camella G. Wilson, Bryan A. Wolf
Publikováno v:
FEBS Letters. 583:3009-3015
PANDER is a cytokine co-secreted with insulin from islet β-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by 125I-PANDER saturation and competitive binding assays. I
Autor:
Claudia E. Robert, James F. Markmann, Ali Naji, Yuan Zhu, Matteo Trucco, Zhiyong Gao, Bryan A. Wolf, Donald H. Campbell, Weizhen Xu, Xiaopei Cao, Gang Xu, Ewan Bell, Scott Greene, Robert J. Young
Publikováno v:
Diabetes. 52:2296-2303
PANDER (PANcreatic DERived factor, FAM3B), a newly discovered secreted cytokine, is specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. To evaluate the role of PANDER in beta-cell function, we investigated the
Autor:
Jianmei Wu, Claudia E. Robert-Cooperman, Jason R. Carnegie, Camella G. Wilson, Jichun Yang, Robert A. Young, Brant R. Burkhardt, Joshua R. Cook, Bryan A. Wolf
Publikováno v:
Diabetes
OBJECTIVE Pancreatic-derived factor (PANDER, FAM3B) is a pancreatic islet-specific cytokine-like protein that is secreted from β-cells upon glucose stimulation. The biological function of PANDER is unknown, and to address this we generated and chara
Autor:
Claudia E. Robert, Robert A. Young, Bryan A. Wolf, Brant R. Burkhardt, Zhiyong Gao, Jichun Yang, Jianmei Wu
Publikováno v:
Diabetes. 54(11)
Pancreatic-derived factor (PANDER) is an islet-specific cytokine present in both pancreatic alpha- and beta-cells, which, in vitro, induces beta-cell apoptosis of primary islet and cell lines. In this study, we investigated whether PANDER is secreted
Autor:
Claudia E. Robert, Zhiyong Gao, Brant R. Burkhardt, Jichun Yang, Helena Gaweska, Scott Greene, Robert A. Young, Bryan A. Wolf, Amary Wagner, Jianmei Wu
Publikováno v:
Biochemistry. 44(34)
PANDER (pancreatic derived factor, FAM3B) is a novel cytokine, present in insulin secretory granules, that induces apoptosis of alpha and beta cells of mouse, rat, and human islets in a dose- and time-dependent manner, and may be implicated in diabet
Autor:
Claudia E. Robert, Ryan K. Wong, Clive Wasserfall, Brant R. Burkhardt, Bryan A. Wolf, Zhiyong Gao, Jichun Yang, Mark A. Atkinson, Jianmei Wu, Scott R. Greene, Todd M. Brusko, Klaus H. Kaestner, Peter White, John Brestelli
Publikováno v:
Gene. 369
PANcreatic DERived factor is an islet-specific cytokine that promotes apoptosis in primary islets and islet cell lines. To elucidate the genetic mechanisms of PANDER-induced cell death we performed expression profiling using the mouse PancChip versio