Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Claudia Diefenbach"'
Autor:
Philipp Badorrek, Claudia Diefenbach, Harald Kögler, Anastasia Eleftheraki, Friedeborg Seitz, Jens M. Hohlfeld
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Novel treatments are needed to reduce inflammation, improve symptoms, address exacerbations, and slow disease progression in bronchiectasis. Cathepsin C (CatC) inhibition promises to achieve this through reduction of neutrophil‐derived ser
Externí odkaz:
https://doaj.org/article/6cf4e4560b7a4ccd929fffaee02c03ff
Autor:
Toby M. Maher, R. Gisli Jenkins, Vincent Cottin, Yasuhiko Nishioka, Imre Noth, Moisés Selman, Jin Woo Song, Carina Ittrich, Claudia Diefenbach, Susanne Stowasser, Eric S. White
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Background We used data from the INMARK trial to investigate associations between circulating biomarkers of extracellular matrix (ECM) turnover, inflammation and epithelial dysfunction and disease progression in subjects with idiopathic pulmonary fib
Externí odkaz:
https://doaj.org/article/ce61e17c82d743fd983423633afe417a
Autor:
James D. Crapo, Abhya Gupta, David A. Lynch, Alice M. Turner, Robert M. Mroz, Wim Janssens, Andrea Ludwig-Sengpiel, Harald Koegler, Anastasia Eleftheraki, Frank Risse, Claudia Diefenbach
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background FOOTPRINTS® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation/lung tissue destruction and chronic obstructive pulmonary disease (COPD) severity and progression in ex-smokers
Externí odkaz:
https://doaj.org/article/707be246bd9b48989989b4dd06d27cbf
Autor:
Christina Hesse, Valerie Beneke, Sebastian Konzok, Claudia Diefenbach, Jannie Marie Bülow Sand, Sarah Rank Rønnow, Morten Asser Karsdal, Danny Jonigk, Katherina Sewald, Armin Braun, Diana Julie Leeming, Lutz Wollin
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-trea
Externí odkaz:
https://doaj.org/article/34a29ce6a5e24095888c0b8a45b0960c
Autor:
James D. Chalmers, Abhya Gupta, Sanjay H. Chotirmall, April Armstrong, Peter Eickholz, Naoki Hasegawa, Pamela J. McShane, Anne E. O'Donnell, Michal Shteinberg, Henrik Watz, Anastasia Eleftheraki, Claudia Diefenbach, Wiebke Sauter
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
New therapies are needed to prevent exacerbations, improve quality of life and slow disease progression in bronchiectasis. Inhibition of cathepsin C (CatC) activity has the potential to decrease activation of neutrophil-derived serine proteases in pa
Externí odkaz:
https://doaj.org/article/f31442a25f82442584c4258c2b47a8fe
Autor:
Christina Hesse, Valerie Beneke, Sebastian Konzok, Claudia Diefenbach, Jannie Marie Bülow Sand, Sarah Rank Rønnow, Morten Asser Karsdal, Danny Jonigk, Katherina Sewald, Armin Braun, Diana Julie Leeming, Lutz Wollin
Publikováno v:
Respiratory research 23, 201 (2022). doi:10.1186/s12931-022-02116-4
Respiratory research 23, 201 (2022). doi:10.1186/s12931-022-02116-4
Published by BioMed Central, London
Published by BioMed Central, London
Autor:
Klaus B Rohr, Eric S. White, Claudia Diefenbach, Bruno Crestani, Toby M. Maher, Manuel Quaresma, Jürgen Behr, Carina Ittrich, Martin Kolb
Publikováno v:
Idiopathic interstitial pneumonias.
Publikováno v:
Airway pharmacology and treatment.
Background: Neutrophil elastase (NE) is increased in COPD sputum and bronchoalveolar lavage fluid and correlates with clinical symptoms. NE inhibition (NEi) may reduce tissue damage and inflammation. Methods: We conducted two Phase I trials: NCT03588
Autor:
Vincent Cottin, Jin Woo Song, Claudia Diefenbach, Carina Ittrich, Toby M. Maher, Yasuhiko Nishioka, Moisés Selman, Gisli Jenkins, Antje Prasse, Imre Noth, Eric S. White, Klaus B Rohr, Susanne Stowasser
Publikováno v:
Idiopathic interstitial pneumonias.
Introduction: The INMARK trial investigated effects of nintedanib on blood biomarkers in subjects with IPF. Aim: To investigate the effect of nintedanib on markers of epithelial damage. Methods: Subjects (n=346) with IPF and FVC ≥80% predicted were
Autor:
Manuel Quaresma, Bruno Crestani, Claudia Diefenbach, Eric S. White, Carina Ittrich, Klaus B Rohr, Toby M. Maher, Martin Kolb, Vincent Cottin
Publikováno v:
Idiopathic interstitial pneumonias.
Introduction: In the INSTAGE trial in subjects with IPF and severely impaired gas exchange, nintedanib plus sildenafil had a numerically greater effect on FVC decline vs nintedanib alone, with more a pronounced effect in subjects with emphysema. Aim: