Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Claudia Di Berardino"'
Autor:
Andrea Balboni, Camilla D’Angelo, Nicoletta Collura, Simone Brusco, Claudia Di Berardino, Altea Targa, Beatrice Massoti, Eloise Mastrangelo, Mario Milani, Pierfausto Seneci, Vania Broccoli, Luca Muzio, Rossella Galli, Andrea Menegon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Glioblastoma (GBM) is the most common malignant primary brain cancer that, despite recent advances in the understanding of its pathogenesis, remains incurable. GBM contains a subpopulation of cells with stem cell-like properties called cance
Externí odkaz:
https://doaj.org/article/d2425d752d414824a5eee89bb1c78547
Autor:
Jonathan H Cornford, Albert Snowball, Claudia Di Berardino, Gabriele Lignani, Stephanie Schorge, Yichen Qiu, Mikail Weston, Gaia Colasante, Serena Giannelli, Luca Massimino, Vania Broccoli, Dimitri M. Kullmann, Andreas Lieb, Steffan P Jones
Publikováno v:
Brain
CRISPRa targets promoters to modulate gene activity. Colasante, Qiu et al. report that CRISPRa upregulation of an endogenous potassium channel reduces seizures and rescues cognitive defects in an epilepsy model. The study provides proof of principle
Autor:
Letizia Leocani, Valerio Castoldi, Timothy Church, Raffaele Ricci, Jenna C Carpenter, Claudia Di Berardino, Silvia Marenna, Stephanie Schorge, Gabriele Lignani, Fabio Benfenati, Dimitri M. Kullmann, Gaia Colasante, Luca Massimino, Simone Bido, Vania Broccoli, Simone Brusco, Serena Giannelli, Nicholas Valassina, Giuseppe Morabito
Publikováno v:
Mol Ther
Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the pathogenic mechanism. Here we tested whether catalytically dead Cas9 (dCas9)-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc44ea332ea26aebe773b0166de647
Autor:
Andrea Menegon, Vania Broccoli, Giulia Regalia, Angelo Iannielli, Cinzia Cancellieri, Claudia Di Berardino, Mirko Luoni, Isabella Radice, Giovanna Lazzari, Stefano Taverna, Serena Giannelli, Alicia Rubio
Publikováno v:
Scientific Reports
The CRISPR/Cas9 system is a rapid and customizable tool for gene editing in mammalian cells. In particular, this approach has widely opened new opportunities for genetic studies in neurological disease. Human neurons can be differentiated in vitro fr