Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Claudia D, Fuchs"'
Autor:
Claudia D. Fuchs, Natalie Sroda, Hubert Scharnagl, Ruchi Gupta, Wesley Minto, Tatjana Stojakovic, John T. Liles, Grant Budas, David Hollenback, Michael Trauner
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100874- (2023)
Background & Aims: The nuclear receptor farnesoid X receptor (FXR) is a key regulator of hepatic bile acid (BA) and lipid metabolism, inflammation and fibrosis. Here, we aimed to explore the potential of cilofexor (GS-9674), a non-steroidal FXR agoni
Externí odkaz:
https://doaj.org/article/98d4075a323d4c7285415bf45d052aaa
Autor:
Claudia D. Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W. Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 5, Pp 847-856 (2023)
Background & Aims: Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue teduglutide has hepatoprotective and antifibrotic effects in the Mdr2/A
Externí odkaz:
https://doaj.org/article/38608f1e5ab54160be285257cf74e3a7
Autor:
Claudia D. Fuchs, Emmanuel D. Dixon, Tim Hendrikx, Veronika Mlitz, Annika Wahlström, Marcus Ståhlman, Hubert Scharnagl, Tatjana Stojakovic, Christoph J. Binder, Hanns‐Ulrich Marschall, Michael Trauner
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2368-2378 (2022)
Abstract Bile salt export pump (Bsep) (Abcb11)−/− mice are protected from acquired cholestatic injury due to metabolic preconditioning with a hydrophilic bile acid (BA) pool with formation of tetrahydroxylated bile acids (THBAs). We aimed to expl
Externí odkaz:
https://doaj.org/article/2eb49cbe92514bb2bf2ca7d245d3ffe7
Autor:
Matteo Tardelli, Francesca V. Bruschi, Thierry Claudel, Claudia D. Fuchs, Nicole Auer, Victoria Kunczer, Tatjana Stojakovic, Hubert Scharnagl, Aida Habib, Gernot F. Grabner, Robert Zimmermann, Sophie Lotersztajn, Michael Trauner
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 7, Pp 1284-1292 (2019)
Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO (MGL−/−) mice were challenged with a Western diet (WD) over 12 weeks. Lipid metaboli
Externí odkaz:
https://doaj.org/article/02a72589b0a44e1baef87dba030ccf71
Autor:
Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis
Publikováno v:
Nature. 615:134-142
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t
Autor:
Matteo Tardelli, Francesca V. Bruschi, Claudia D. Fuchs, Thierry Claudel, Nicole Auer, Victoria Kunczer, Onne A. H. O. Ronda, Henkjan J. Verkade, Tatjana Stojakovic, Hubert Scharnagl, Michael Trauner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2126 (2021)
Altered lipid metabolic pathways including hydrolysis of triglycerides are key players in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Whether adiponutrin (patatin-like phospholipase domain containing protein-3—PNPLA3) and monoacyl
Externí odkaz:
https://doaj.org/article/6d73bead7c4e4a43bc5852dcf7fe6cad
Autor:
Claudia D. Fuchs, Michael Trauner
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 19:432-450
Autor:
Merima Herac, Gerald Timelthaler, Claudia D. Fuchs, Michael Trauner, Tatjana Stojakovic, Richard Radun, Emina Halilbasic, Johan W. Jonker, Guenter Haemmerle, Matteo Tardelli, Emmanuel D Dixon, Veronika Mlitz, Henkjan J. Verkade, Onne A H O Ronda, Robert Zimmermann, Hubert Scharnagl
Publikováno v:
Hepatology, 75(1), 125-139. Wiley
BACKGROUND AND AIMS: Increased fatty acid (FA) flux from adipose tissue to the liver contributes to the development of NAFLD. Because free FAs are key lipotoxic triggers accelerating disease progression, inhibiting adipose triglyceride lipase (ATGL)/
Autor:
Jelena Remetic, Michael Trauner, Alexander Lercher, Thierry Claudel, Lisa Sandner, Anna Ohradanova-Repic, Matarr Khan, Wilfried Ellmeier, Nicole Boucheron, Alexandra Franziska Gülich, Emina Halilbasic, Thomas Weichhart, Claudia D. Fuchs, Andreas Bergthaler, Patricia Hamminger, C. Viczenczova, Clemens Donner, Philipp Schatzlmaier, Daniela Hainberger, Peter Májek, Hubert Scharnagl, André C. Müller, Hannes Stockinger, Teresa Preglej, Ci Zhu, Shinya Sakaguchi, Marlis Alteneder, Tatjana Stojakovic, Hatoon Baazim
Publikováno v:
Journal of Hepatology
Background & Aims 24-Norursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid used to treat immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC), where dysregulated T cells including CD8+ T cells contribu
Autor:
Ci Zhu, Nicole Boucheron, Ramona Rica, Valentina Stolz, Emina Halilbasic, Thierry Claudel, Osamah Al-Rubaye, Alexander Lercher, Maximilian Baumgartner, Lisa Sandner, Teresa Preglej, Marlis Alteneder, Veronika Mlitz, Claudia D. Fuchs, Daniela Hainberger, Jelena Remetic, Anna Ohradanova-Repic, Philipp Schatzlmaier, Tatjana Stojakovic, Hubert Scharnagl, Shinya Sakaguchi, Andreas Bergthaler, Hannes Stockinger, Wilfried Ellmeier, Michael Trauner
Objective24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating primary sclerosing cholangitis (PSC), an immune-mediated cholestatic liver disease. Since PSC strongly associates with inflammatory bowel diseases (IBD) driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8263ba9277e30708557ec5cfc1446399
https://doi.org/10.1101/2022.02.10.479975
https://doi.org/10.1101/2022.02.10.479975