Výsledky vyhledávání - "Claudia C. Roskopf"

Akademický článek

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells

Autor: Todd A. Braciak, Claudia C. Roskopf, Sarah Wildenhain, Nadja C. Fenn, Christian B. Schiller, Ingo A. Schubert, Uwe Jacob, Annemarie Honegger, Christina Krupka, Marion Subklewe, Karsten Spiekermann, Karl-Peter Hopfner, Georg H. Fey, Michael Aigner, Stefan Krause, Andreas Mackensen, Fuat S. Oduncu

Publikováno v: OncoImmunology, Vol 7, Iss 9 (2018)

A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single antigen on the surface of AML cells. Here we describe the development and key biological pro

Externí odkaz: https://doaj.org/article/9c33b3300b544ab9bf536064eecde761

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T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell

Autor: Todd A. Braciak, Sebastian Kobold, Fuat Oduncu, Karl-Peter Hopfner, Georg H. Fey, Christian B. Schiller, Claudia C. Roskopf, Ingo Schubert

Publikováno v: Oncotarget
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Triplebody 19-3-19, an antibody-derived protein, carries three single chain fragment variable domains in tandem in a single polypeptide chain. 19-3-19 binds CD19-bearing lymphoid cells via its two distal domains and primary T cells via its CD3-target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13efc4aaf1957fda0ce2af7775f1e8b
https://doi.org/10.18632/oncotarget.2238

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CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

Autor: Karl-Peter Hopfner, Alexandra Schele, Ursula J.E. Seidel, Nadja C. Fenn, Annemarie Honegger, Christian B. Schiller, Todd A. Braciak, Sarah Wildenhain, Fuat Oduncu, Ingo Schubert, Kerstin Lämmermann, Peter Lang, Georg H. Fey, Claudia C. Roskopf, Uwe Jacob

Publikováno v: Oncotarget

// Christian B. Schiller 1, * , Todd A. Braciak 2, * , Nadja C. Fenn 1, * , Ursula J. E. Seidel 3, * , Claudia C. Roskopf 2, * , Sarah Wildenhain 1, * , Annemarie Honegger * , Ingo A. Schubert 5 , Alexandra Schele 1 , Kerstin Lammermann 2 , Georg H.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9594975ab5fee990d155d3a61be0db
https://pubmed.ncbi.nlm.nih.gov/27825135

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Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody

Autor: Claudia C. Roskopf, Farzad Sekhavati, Nadja C. Fenn, Georg H. Fey, Todd A. Braciak, Elisavet I. Chatzopoulou, Karl-Peter Hopfner, Joachim O. Rädler, Fuat Oduncu

Cancer therapy via redirected lysis mediated by antibodies and antibody-derived agents relies on the availability of substantial numbers of sufficiently active immune effector cells. To monitor antitumor responses before and during therapy, sensitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aec674a3682ab1b80aa8f496af93820
https://opus4.kobv.de/opus4-fau/files/9226/Chatzopoulou_chip-based.pdf

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Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells

Autor: Nadja C. Fenn, Todd A. Braciak, Claudia C. Roskopf, Sebastian Kobold, Karl-Peter Hopfner, Georg H. Fey, Fuat Oduncu

Publikováno v: Oncotarget

Simultaneous targeting of multiple tumor-associated antigens (TAAs) in cancer immunotherapy is presumed to enhance tumor cell selectivity and to reduce immune escape. The combination of B lymphoid marker CD19 and myeloid marker CD33 is exclusively pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1a08b07bbc9e91b2161066e6d0d677
https://pubmed.ncbi.nlm.nih.gov/26981773

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P28. Efficient CD19-positive leukaemia cell lysis mediated by a T cell-recruiting triple body a[19-3-19]

Autor: Karl-Peter Hopfner, Nadja C. Fenn, Sarah Wildenhain, Christian B. Schiller, Uwe Jacob, Fuat Oduncu, Claudia C. Roskopf, Todd A. Braciak, Georg H. Fey

Publikováno v: Journal for Immunotherapy of Cancer

Meeting abstracts The design of antibody derivatives with higher tumour cell selectivity is hoped to improve cancer immunotherapy and to decrease side effects. One promising molecular format that we have developed is the triple body. A triple body al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b2e7e8f0b8dd19886994d380411974
https://doi.org/10.1186/2051-1426-2-s2-p19

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Interactions among Lung Cancer Cells, Fibroblasts, and Macrophages in 3D Co-Cultures and the Impact on MMP-1 and VEGF Expression

Autor: Rudolf M. Huber, Fei Tian, Claudia C. Roskopf, Xiao-qing Liu, Rosemarie Kiefl

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0156268 (2016)

In vitro cell-based models of lung cancer are frequently employed to study invasion and the mechanisms behind metastasis. However, these models often study only one cell type with two-dimensional (2D) monolayer cell cultures, which do not accurately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192beb007b8c6e96308cc43e299af4e4
https://doi.org/10.1371/journal.pone.0156268

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NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2

Autor: Todd A. Braciak, Claudia C. Roskopf, Sarah Wildenhain, Georg H. Fey, Uwe Jacob, Fuat Oduncu, Ingo Schubert, Karl-Peter Hopfner

Publikováno v: Journal of Translational Medicine

Background The capacity of patient’s Natural Killer cells (NKs) to be activated for cytolysis is an important prerequisite for the success of antibody-derived agents such as single-chain triplebodies (triplebodies) in cancer therapy. NKs recovered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b50c123c27d23cdcd2ec6400e041a
https://doi.org/10.1186/1479-5876-11-289

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