T Cell‐Mediated Transport of Polymer Nanoparticles across the Blood–Brain Barrier

Autor: Arne Seitz, Olivier Burri, Gaby Enzmann, Markus Schuster, Harm-Anton Klok, Britta Engelhardt, Claudia Blatti, Maxime Ayer, Isabelle Gruber, Elisa Kaba, Romain Guiet

Publikováno v: Ayer, Maxime; Schuster, Markus; Gruber, Isabelle; Blatti, Claudia; Kaba, Elisa; Enzmann, Gaby; Burri, Olivier; Guiet, Romain; Seitz, Arne; Engelhardt, Britta; Klok, Harm-Anton (2021). T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier. Advanced healthcare materials, 10(2), e2001375. Wiley 10.1002/adhm.202001375

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6a62b5b19674c367a9e6b9ce2f6df0
https://doi.org/10.1002/adhm.202001375

Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro

Autor: Henriette Rudolph, Claudia Blatti, Isabelle Gruber, Armelle Klopstein, Ruth Lyck, Britta Engelhardt

Publikováno v: European journal of immunology
European Journal of Immunology
Rudolph, Henriette; Klopstein, Armelle; Gruber, Isabelle Manuela; Blatti, Claudia; Lyck, Ruth; Engelhardt, Britta (2016). Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro. European journal of immunology, 46(9), pp. 2187-2203. Wiley-VCH 10.1002/eji.201546251

Although CD8(+) T cells have been implied in the pathogenesis of multiple sclerosis (MS), the molecular mechanisms mediating CD8(+) T-cell migration across the blood-brain barrier (BBB) into the central nervous system (CNS) are ill defined. Using in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa09824e0118743c985bf8ec8036a58

Identification of subset specific mechanisms for CD8+ versus CD4+ TEM cells mediating their migration across the inflamed blood–brain barrier under physiological flow in vitro

Autor: Britta Engelhardt, Horst Schroten, Claudia Blatti, Ruth Lyck, Henriette Rudolph

Publikováno v: Journal of Neuroimmunology. 275:33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9477cf822e50a2693ce81664da95ca4
https://doi.org/10.1016/j.jneuroim.2014.08.090

A novel classification of quiescent and transit amplifying adult neural stem cells by surface and metabolic markers permits a defined simultaneous isolation

Autor: Roberto Fiorelli, Bjoern Zoerner, Sarah Beyeler, Michaela Thallmair, Franz-Josef Obermair, Aileen Schroeter, Claudia Blatti

Publikováno v: Stem Cell Research. (2):131-143

Adult neural stem and progenitor cells (NSPCs) are usually defined retrospectively by their ability to proliferate in vivo (bromodeoxyuridine uptake) or to form neurospheres and to differentiate into neurons, astrocytes and oligodendrocytes in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ec3021f046fd28e687634d4970bf53