Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Claudia Augusta Di Trani"'
Autor:
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Maite Alvarez, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Nuria Ardaiz, Alvaro Teijeira, Elixabet Bolaños, José González-Gomariz, Itziar Otano, Fernando Aranda, Belén Palencia, Aina Segués, Shuyu Huang, Sander M.J. van Duijnhoven, Andrea van Elsas, Ignacio Melero, Pedro Berraondo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 599-616 (2023)
IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic. Currently, the intratumoral injection of IL-12-encoding mRNA or DNA to avoid such side effects
Externí odkaz:
https://doaj.org/article/b7ab44ddf91c4d09a6a701937d803612
Autor:
Assunta Cirella, Elixabet Bolaños, Carlos Luri-Rey, Claudia Augusta Di Trani, Irene Olivera, Gabriel Gomis, Javier Glez-Vaz, Beatrice Pinci, Saray Garasa, Sandra Sánchez-Gregorio, Arantza Azpilikueta, Iñaki Eguren-Santamaria, Karmele Valencia, Belén Palencia, Maite Alvarez, Maria C. Ochoa, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 668-682 (2023)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed c
Externí odkaz:
https://doaj.org/article/0cbeb48e82c4432eb1d5f41226df6231
Autor:
Pedro Berraondo, Ignacio Melero, Marisol Quintero, Fernando Aranda, Maite Alvarez, Henning Lauterbach, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella, Jose Gonzalez-Gomariz, Leire Arrizabalaga, Joan Salvador Russo-Cabrera, Timo Schippers, Klaus K Orlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Lymphocytic choriomeningitis virus (LCMV) belongs to the Arenavirus family known for inducing strong cytotoxic T-cell responses in both mice and humans. LCMV has been engineered for the development of cancer immunotherapies, currently unde
Externí odkaz:
https://doaj.org/article/4dfa0ffddcda4cb18561d27f12fde8c9
Autor:
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient con
Externí odkaz:
https://doaj.org/article/7995ddacfe9f449ca1ff8dccf0f9a256
Autor:
Pedro Berraondo, Ignacio Melero, Jose Medina-Echeverz, Alvaro Teijeira, Fernando Aranda, Maite Alvarez, Assunta Cirella, Maria Hinterberger, Hubertus Hochrein, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Celia Gomar, Angela Bella, Cigdem Atay, Jose Gonzalez-Gomariz, Irene Olivera, Leire Arrizabalaga, Joan Salvador Russo-Cabrera
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Peritoneal carcinomatosis is an advanced stage of cancer in which the disease has spread to the peritoneal cavity. In order to restore antitumor immunity subverted by tumor cells in this location, we evaluated intraperitoneal administratio
Externí odkaz:
https://doaj.org/article/602c6ffcbd964839b726a8c63461e54e
Autor:
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin, Celia Gomar, Joan Salvador Russo-Cabrera, Inmaculada Rodríguez, José González-Gomariz, Maite Alvarez, Álvaro Teijeira, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the exp
Externí odkaz:
https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8
Autor:
Pedro Berraondo, Ignacio Melero, Jose Medina-Echeverz, Fernando Aranda, Maite Alvarez, Itziar Otano, Shirley Tenesaca, Marcos Vasquez, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated type I interferon (IFN) response and the production of high levels
Externí odkaz:
https://doaj.org/article/134f9c1a54df4aa3bb55a02d549a7554
Autor:
Annapaola Angrisani, Annamaria Di Fiore, Claudia Augusta Di Trani, Simone Fonte, Marialaura Petroni, Ludovica Lospinoso Severini, Fabio Bordin, Laura Belloni, Elisabetta Ferretti, Gianluca Canettieri, Marta Moretti, Enrico De Smaele
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The Hedgehog (Hh) signaling pathway plays a crucial role in normal embryonic development and adult tissue homeostasis. On the other end, dysregulated Hh signaling triggers a prolonged mitogenic response that may prompt abnormal cell proliferation, fa
Externí odkaz:
https://doaj.org/article/df5ec94c1e6e442f8ba4fa7edc3ad6c2
Autor:
Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Angela Bella, Marcos Vasquez, Nuria Ardaiz, Celia Gomar, Leire Arrizabalaga, Sergio Ciordia, Fernando J. Corrales, Fernando Aranda, Pedro Berraondo
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Apolipoprotein A-I mimetic peptides are amphipathic alpha-helix peptides that display similar functions to apolipoprotein A-I. Preclinical and clinical studies have demonstrated the safety and efficacy of apolipoprotein A-I mimetic peptides in multip
Externí odkaz:
https://doaj.org/article/f30515eb133e49479c29e4d0cb9efff2
Autor:
Nuria Ardaiz, Celia Gomar, Marcos Vasquez, Shirley Tenesaca, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Virginia Belsué, Javier Escalada, Ulrich Werner, Norbert Tennagels, Pedro Berraondo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Targeting long-lasting insulins to the liver may improve metabolic alterations that are not corrected with current insulin replacement therapies. However, insulin is only able to promote lipogenesis but not to block gluconeogenesis in the
Externí odkaz:
https://doaj.org/article/8e9213d3a8314d028710dd77a2e0ed10