Inflammatory breast cancer microenvironment repertoire based on DNA methylation data deconvolution reveals actionable targets to enhance the treatment efficacy

Autor: Naiade Calanca, Flavia Lima Costa Faldoni, Cristiano Pádua Souza, Jeferson Santos Souza, Bianca Elen de Souza Alves, Milena Botelho Pereira Soares, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima-Junior, Fabio Albuquerque Marchi, Claudia Aparecida Rainho, Silvia Regina Rogatto

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Abstract Background Although the clinical signs of inflammatory breast cancer (IBC) resemble acute inflammation, the role played by infiltrating immune and stromal cells in this aggressive disease is uncharted. The tumor microenvironment (TME) presen

Externí odkaz: https://doaj.org/article/7c7f9e10179346a1b0da0fcab74047f7

DNA methylation-based depiction of the immune microenvironment and immune-associated long non-coding RNAs in oral cavity squamous cell carcinomas

Autor: Naiade Calanca, Ana Lucia Noronha Francisco, Daniela Bizinelli, Hellen Kuasne, Mateus Camargo Barros Filho, Bianca Campos Troncarelli Flores, Clóvis Antonio Lopes Pinto, Claudia Aparecida Rainho, Milena Botelho Pereira Soares, Fabio Albuquerque Marchi, Luiz Paulo Kowalski, Silvia Regina Rogatto

Publikováno v: Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115559- (2023)

Oral cavity squamous cell carcinoma (OSCC) is a complex and dynamic disease characterized by clinicopathological and molecular heterogeneity. Spatial and temporal heterogeneity of cell subpopulations has been associated with cancer progression and im

Externí odkaz: https://doaj.org/article/5d77f3e1e09e428e8d390ea47ed26220

Master Regulators of Epithelial-Mesenchymal Transition and WNT Signaling Pathways in Juvenile Nasopharyngeal Angiofibromas

Autor: Naiade Calanca, Sara Martoreli Silveira Binato, Sabrina Daniela da Silva, Helena Paula Brentani, Luiz Ubirajara Sennes, Clóvis Antonio Lopes Pinto, Maria Aparecida Custódio Domingues, Carlos Eduardo Fonseca-Alves, Claudia Aparecida Rainho, Silvia Regina Rogatto

Publikováno v: Biomedicines, Vol 9, Iss 9, p 1258 (2021)

Juvenile nasopharyngeal angiofibroma (JNA) is a rare fibrovascular benign tumor showing an invasive growth pattern and affecting mainly male adolescents. We investigated the role of epithelial–mesenchymal transition (EMT) and WNT signaling pathways

Externí odkaz: https://doaj.org/article/bebe8738d9f64cb9b9aa66c97e28fbb2

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

Autor: Helena, Brentani, Otávia L, Caballero, Anamaria A, Camargo, Aline M, da Silva, Wilson Araújo, da Silva, Emmanuel, Dias Neto, Marco, Grivet, Arthur, Gruber, Pedro Edson Moreira, Guimaraes, Winston, Hide, Christian, Iseli, C Victor, Jongeneel, Janet, Kelso, Maria Aparecida, Nagai, Elida Paula Benquique, Ojopi, Elisson C, Osorio, Eduardo M R, Reis, Gregory J, Riggins, Andrew John George, Simpson, Sandro, de Souza, Brian J, Stevenson, Robert L, Strausberg, Eloiza H, Tajara, Sergio, Verjovski-Almeida, Marcio Luis, Acencio, Mário Henrique, Bengtson, Fabiana, Bettoni, Walter F, Bodmer, Marcelo R S, Briones, Luiz Paulo, Camargo, Webster, Cavenee, Janete M, Cerutti, Luis Eduardo, Coelho Andrade, Paulo César, Costa dos Santos, Maria Cristina, Ramos Costa, Israel Tojal, da Silva, Marcos Roberto H, Estécio, Karine, Sa Ferreira, Frank B, Furnari, Milton, Faria, Pedro A F, Galante, Gustavo S, Guimaraes, Adriano Jesus, Holanda, Edna Teruko, Kimura, Maarten R, Leerkes, Xin, Lu, Rui M B, Maciel, Elizabeth A L, Martins, Katlin Brauer, Massirer, Analy S A, Melo, Carlos Alberto, Mestriner, Elisabete Cristina, Miracca, Leandro Lorenco, Miranda, Francisco G, Nobrega, Paulo S, Oliveira, Apua C M, Paquola, José Rodrigo C, Pandolfi, Maria Ines de Moura, Campos Pardini, Fabio, Passetti, John, Quackenbush, Beatriz, Schnabel, Mari Cleide, Sogayar, Jorge E, Souza, Sandro R, Valentini, Andre C, Zaiats, Elisabete Jorge, Amaral, Liliane A T, Arnaldi, Amelia Goes, de Araújo, Simone Aparecida, de Bessa, David C, Bicknell, Maria Eugenia, Ribeiro de Camaro, Dirce Maria, Carraro, Helaine, Carrer, Alex F, Carvalho, Christian, Colin, Fernando, Costa, Cyntia, Curcio, Ismael Dale Cotrim, Guerreiro da Silva, Neusa, Pereira da Silva, Márcia, Dellamano, Hamza, El-Dorry, Enilza Maria, Espreafico, Ari José, Scattone Ferreira, Cristiane, Ayres Ferreira, Maria Angela H Z, Fortes, Angelita Habr, Gama, Daniel, Giannella-Neto, Maria Lúcia C C, Giannella, Ricardo R, Giorgi, Gustavo Henrique, Goldman, Maria Helena S, Goldman, Christine, Hackel, Paulo Lee, Ho, Elza Myiuki, Kimura, Luiz Paulo, Kowalski, Jose E, Krieger, Luciana C C, Leite, Ademar, Lopes, Ana Mercedes S C, Luna, Alan, Mackay, Suely Kazue Nagahashi, Mari, Adriana Aparecida, Marques, Waleska K, Martins, André, Montagnini, Mario, Mourão Neto, Ana Lucia T O, Nascimento, A Munro, Neville, Marina P, Nobrega, Mike J, O'Hare, Audrey Yumi, Otsuka, Anna Izabel, Ruas de Melo, Maria Luisa, Paco-Larson, Gonçalo, Guimarães Pereira, Joao Bosco, Pesquero, Juliana Gilbert, Pessoa, Paula, Rahal, Claudia Aparecida, Rainho, Vanderlei, Rodrigues, Silvia Regina, Rogatto, Camila Malta, Romano, Janaina Gusmao, Romeiro, Benedito Mauro, Rossi, Monica, Rusticci, Renata, Guerra de Sá, Simone Cristina, Sant' Anna, Miriam L, Sarmazo, Teresa Cristina de Lima E, Silva, Fernando Augusto, Soares, Maria de Fátima, Sonati, Josane, de Freitas Sousa, Diana, Queiroz, Valéria, Valente, André Luiz, Vettore, Fabiola Elizabeth, Villanova, Marco Antonio, Zago, Heloisa, Zalcberg

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 100(23)

Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7e46ed91748cacbfe8d981929696a8
https://pubmed.ncbi.nlm.nih.gov/14593198

Expressão de RNAs não codificadores intrônicos longos em linhagens celulares humanas e o seu controle epigenético por metilação do DNA

Autor: Lauren Camargo

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Estudos recentes têm revelado que uma fração significativa do transcriptoma de eucariotos é composta por RNAs não codificadores longos (lncRNAs). Este trabalho investigou o padrão de expressão de um conjunto de lncRNAs originados a partir de r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2e32f0f88d58260877f5d8eb083308
https://doi.org/10.11606/t.46.2012.tde-10062013-104932