Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Claudia A. Benavente"'
Autor:
Yijun Gu, Claudia A. Benavente
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 11, p 3120 (2024)
Small cell lung cancer (SCLC) is a deadly neuroendocrine malignancy, notorious for its rapid tumor growth, early metastasis, and relatively “cold” immune environment. Only standard chemotherapies and a few immune checkpoint inhibitors have been a
Externí odkaz:
https://doaj.org/article/d4e33711f1d0445693d479256c94645a
Autor:
Claire C. Chen, Claudia A. Benavente
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 568 (2024)
Osteosarcoma (OS) is a primary malignant bone tumor with high metastasis. Poor prognosis highlights a clinical need for novel therapeutic strategies. Exosomes, also known as extracellular vesicles, have been identified as essential players in the mod
Externí odkaz:
https://doaj.org/article/79d429ee8fdf45009a632e65cd18cba6
Autor:
Stephanie C. Wu, Ahhyun Kim, Yijun Gu, Daniel I. Martinez, Loredana Zocchi, Claire C. Chen, Jocelyne Lopez, Kelsey Salcido, Sarah Singh, Jie Wu, Ali Nael, Claudia A. Benavente
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Loss-of-function mutations at the retinoblastoma (RB1) gene are associated with increased mortality, metastasis, and poor therapeutic outcome in several cancers, including osteosarcoma. However, the mechanism(s) through which RB1 loss worsen
Externí odkaz:
https://doaj.org/article/03dd0841ee8948ffa1fd264bf58aa27d
Autor:
Shuxiong Wang, Michael L. Drummond, Christian F. Guerrero-Juarez, Eric Tarapore, Adam L. MacLean, Adam R. Stabell, Stephanie C. Wu, Guadalupe Gutierrez, Bao T. That, Claudia A. Benavente, Qing Nie, Scott X. Atwood
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mechanisms regulating stem cells to give rise to human interfollicular epidermis are unclear. Here, the authors use single cell RNA sequencing to identify heterogeneity within the human neonatal interfollicular epidermis and distinct spatial posi
Externí odkaz:
https://doaj.org/article/e3323cb879d1430da063e81e74e2181d
Autor:
Frederick Guzman, Yasamin Fazeli, Meagan Khuu, Kelsey Salcido, Sarah Singh, Claudia A. Benavente
Publikováno v:
Cancers, Vol 12, Iss 10, p 2807 (2020)
Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during
Externí odkaz:
https://doaj.org/article/cfe0485cf1b847f28d172c643a746dca
Autor:
Meagan Khuu, Kelsey Salcido, Claudia A. Benavente, Frederick Guzman, Sarah Singh, Yasamin Fazeli
Publikováno v:
Cancers, Vol 12, Iss 2807, p 2807 (2020)
Cancers
Cancers, vol 12, iss 10
Cancers
Cancers, vol 12, iss 10
Simple Summary Loss of function of the retinoblastoma gene (RB1) is the rate-limiting step in the initiation of both the hereditary and sporadic forms of retinoblastoma tumor. Furthermore, loss of function of the retinoblastoma tumor suppressor prote
Autor:
Scott X. Atwood, Adam L. MacLean, Christian F. Guerrero-Juarez, Stephanie C Wu, Claudia A. Benavente, Shuxiong Wang, Bao T. That, Qing Nie, Eric Tarapore, Guadalupe Gutierrez, Michael L. Drummond, Adam R. Stabell
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2151c53f7788395f28964c0ed55d831b
https://escholarship.org/uc/item/37s616c7
https://escholarship.org/uc/item/37s616c7
Autor:
Ahhyun Kim, Claire Chen, Loredana Zocchi, Claudia A. Benavente, Jocelyne Lopez, Stephanie C. Wu, Jie Wu, Kelsey Salcido
Loss of function mutations at the retinoblastoma (RB1) gene are associated with increased mortality, metastasis and poor therapeutic outcome in several cancers, including osteosarcoma (OS). However, the mechanism(s) through whichRB1loss worsens clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d28e523cd61079a56c5b861f6c7779b
https://doi.org/10.1101/2020.05.24.113647
https://doi.org/10.1101/2020.05.24.113647
Publikováno v:
Oncoscience
Oncoscience, vol 7, iss 3-4
Oncoscience, vol 7, iss 3-4
Autor:
Claudia A. Benavente, Stephanie C Wu
Publikováno v:
Oncotarget
Oncotarget, vol 9, iss 66
Wu, SC; & Benavente, CA. (2018). Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis. Oncotarget, 9(66), 32580-32592. doi: 10.18632/oncotarget.25953. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4zd0q6vq
Oncotarget, vol 9, iss 66
Wu, SC; & Benavente, CA. (2018). Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis. Oncotarget, 9(66), 32580-32592. doi: 10.18632/oncotarget.25953. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4zd0q6vq
© Wu et al. Osteosarcoma is the most common primary bone malignancy in children and adolescents. Among the various molecular mechanisms implicated in osteosarcomagenesis, the RB-E2F pathway is of particular importance as virtually all cases of osteo