Genomic insights into host and parasite interactions during intracellular infection by Toxoplasma gondii.

Autor: Netha Ulahannan, Ronald Cutler, Reanna Doña-Termine, Claudia A Simões-Pires, N Ari Wijetunga, Matthew McKnight Croken, Andrew D Johnston, Yu Kong, Shahina B Maqbool, Masako Suzuki, John M Greally

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0275226 (2022)

To gain insights into the molecular interactions of an intracellular pathogen and its host cell, we studied the gene expression and chromatin states of human fibroblasts infected with the Apicomplexan parasite Toxoplasma gondii. We show a striking ac

Externí odkaz: https://doaj.org/article/af22b0789185460b95069884872c8950

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6

Autor: Mohamed D. M. Traoré, Vincent Zwick, Claudia A. Simões-Pires, Alessandra Nurisso, Mark Issa, Muriel Cuendet, Marjorie Maynadier, Sharon Wein, Henri Vial, Helene Jamet, Yung-Sing Wong

Publikováno v: ACS Omega, Vol 2, Iss 4, Pp 1550-1562 (2017)

Externí odkaz: https://doaj.org/article/ee61c804c38643ec997c1930494af5e4

A Cellular Stress Response Induced by the CRISPR-dCas9 Activation System Is Not Heritable Through Cell Divisions

Autor: Alali Abdulrazak, Andrew D. Johnston, Shahina Maqbool, Masako Suzuki, Claudia A. Simões-Pires, Hanae Sato, John M. Greally

Publikováno v: The CRISPR journal. 3(3)

The CRISPR/Cas9 system can be modified to perform ‘epigenetic editing’ by utilizing the catalytically-inactive (dead) Cas9 (dCas9) to recruit regulatory proteins to specific genomic locations. In prior studies, epigenetic editing with multimers o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0920ee6afc9da38284706a89f6ee14
https://pubmed.ncbi.nlm.nih.gov/33560917

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6

Autor: Claudia A. Simões-Pires, Yung-Sing Wong, Mohamed Dit Mady Traoré, Vincent Zwick, Sharon Wein, Muriel Cuendet, Marjorie Maynadier, Mark E. Issa, Alessandra Nurisso, Henri Vial, Hélène Jamet

Publikováno v: ACSOmega
ACS Omega
ACS Omega, Vol. 2, No 4 (2017) pp. 1550-1562
ACS Omega, Vol 2, Iss 4, Pp 1550-1562 (2017)
ACS Omega, ACS Publications, 2017, 2 (4), pp.1550-1562. ⟨10.1021/acsomega.6b00481⟩

Little is known about the biological and structural features that govern the isoform selectivity for class I histone deacetylases (HDACs) over HDAC6. In addition to that for known inhibitors, like benzamides, psammaplin A, and cyclodepsipeptide-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7e042e3b919823a01ddf17b882dc4b
http://pubs.acs.org/doi/abs/10.1021/acsomega.6b00481

UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

Autor: Laurence Marcourt, Vincent Zwick, Pierre-Marie Allard, Katia Gindro, Lucie Ory, Jean-Luc Wolfender, Claudia A. Simões-Pires, Muriel Cuendet

Publikováno v: Phytochemical Analysis. 28:93-100

Introduction Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b2a031951c1cb9a72525fb8c2df044
https://doi.org/10.1002/pca.2652