Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Claudia, Saitta"'
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Akademický článek
Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia
Autor: Chiara Palmi, Silvia Bresolin, Stefanie Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Sanil Bhatia, Arndt Borkhardt, Claudia Saitta, Marta Galbiati, Michela Bardini, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruy te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Publikováno v: HemaSphere, Vol 7, Iss 6, p e892 (2023)
Children with Down syndrome have an augmented risk for B-cell acute lymphoblastic leukemia (DS-ALL), which is associated with lower survival than in non-DS-ALL. It is known that cytogenetic abnormalities common in childhood ALL are less frequent in D
Externí odkaz: https://doaj.org/article/8b3553e763074371b4c8f44d90e57a09
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4
Akademický článek
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120
Autor: Grazia Fazio, Silvia Bresolin, Daniela Silvestri, Manuel Quadri, Claudia Saitta, Elena Vendramini, Barbara Buldini, Chiara Palmi, Michela Bardini, Andrea Grioni, Silvia Rigamonti, Marta Galbiati, Stefano Mecca, Angela Maria Savino, Alberto Peloso, Jia-Wey Tu, Sanil Bhatia, Arndt Borkhardt, Concetta Micalizzi, Luca Lo Nigro, Franco Locatelli, Valentino Conter, Carmelo Rizzari, Maria Grazia Valsecchi, Geertruij te Kronnie, Andrea Biondi, Giovanni Cazzaniga
Publikováno v: EBioMedicine, Vol 83, Iss , Pp 104224- (2022)
Summary: Background: Despite intensive risk-based treatment protocols, 15% of paediatric patients with B-Cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL) experience relapse. There is urgent need of novel strategies to target poor prognosis subg
Externí odkaz: https://doaj.org/article/17f5ee578ac94300bf285fbf5e61cf13
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5
Akademický článek
NIPBL: a new player in myeloid cell differentiation
Autor: Mara Mazzola, Gianluca Deflorian, Alex Pezzotta, Laura Ferrari, Grazia Fazio, Erica Bresciani, Claudia Saitta, Luca Ferrari, Monica Fumagalli, Matteo Parma, Federica Marasca, Beatrice Bodega, Paola Riva, Franco Cotelli, Andrea Biondi, Anna Marozzi, Gianni Cazzaniga, Anna Pistocchi
Publikováno v: Haematologica, Vol 104, Iss 7 (2019)
The nucleophosmin 1 gene (NPM1) is the most frequently mutated gene in acute myeloid leukemia. Notably, NPM1 mutations are always accompanied by additional mutations such as those in cohesin genes RAD21, SMC1A, SMC3, and STAG2 but not in the cohesin
Externí odkaz: https://doaj.org/article/2a860a51750740278fb6788ba7cc49e3
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6
Akademický článek
A Simple RNA Target Capture NGS Strategy for Fusion Genes Assessment in the Diagnostics of Pediatric B-cell Acute Lymphoblastic Leukemia
Autor: Andrea Grioni, Grazia Fazio, Silvia Rigamonti, Vojtech Bystry, Giulia Daniele, Zuzana Dostalova, Manuel Quadri, Claudia Saitta, Daniela Silvestri, Simona Songia, Clelia T. Storlazzi, Andrea Biondi, Nikos Darzentas, Giovanni Cazzaniga
Publikováno v: HemaSphere, Vol 3, Iss 3 (2019)
Abstract. Acute lymphoblastic leukemia (ALL) is the most frequent pediatric cancer. Fusion genes are hallmarks of ALL, and they are used as biomarkers for risk stratification as well as targets for precision medicine. Hence, clinical diagnostics purs
Externí odkaz: https://doaj.org/article/169ff7af2f67447fae29c9a888b4b928
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