Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Claudia, Sagheddu"'
Publikováno v:
Cells, Vol 13, Iss 21, p 1809 (2024)
The mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (VTA) of the midbrain shows a profound reduction in function during cannabinoid withdrawal. This condition may underlie aversive states that lead to compulsi
Externí odkaz:
https://doaj.org/article/19a48f0e6e7048ad9045c2d427e83fac
Autor:
Claudia Sagheddu, Tamara Stojanovic, Shima Kouhnavardi, Artem Savchenko, Ahmed M. Hussein, Marco Pistis, Francisco J. Monje, Roberto Plasenzotti, Mohammed Aufy, Christian R. Studenik, Jana Lubec, Gert Lubec
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionDeterioration of cognitive functions is commonly associated with aging, although there is wide variation in the onset and manifestation. Albeit heterogeneity in age-related cognitive decline has been studied at the cellular and molecular
Externí odkaz:
https://doaj.org/article/71955093d7d1495cbc30f67de0923ba9
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Experimental and clinical evidence indicates a deficit of release and function of dopamine in schizophrenia and suggests that α2-adrenoceptor antagonists rescue dopamine deficit and improve the antipsychotic efficacy of D2-receptor antagonists. In a
Externí odkaz:
https://doaj.org/article/250721cb9ff2489ca6c02739cc13b0b5
Autor:
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lubec
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 467 (2023)
The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (DAT)
Externí odkaz:
https://doaj.org/article/31e9c20c5680455db70326abd3c16764
Autor:
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta
Publikováno v:
Cells, Vol 11, Iss 17, p 2628 (2022)
Parkinson’s disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in limbic and neocortica
Externí odkaz:
https://doaj.org/article/3eedc67be715406cbd276027691c9ffd
Autor:
Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragačević, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 881 (2022)
Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning and memory, and social and re
Externí odkaz:
https://doaj.org/article/ea4993ee98834d4a80993681061f26a1
Autor:
Michele Santoni, Claudia Sagheddu, Valeria Serra, Rafaela Mostallino, Maria Paola Castelli, Francesco Pisano, Maria Scherma, Paola Fadda, Anna Lisa Muntoni, Erica Zamberletti, Tiziana Rubino, Miriam Melis, Marco Pistis
Publikováno v:
Brain, Behavior, and Immunity. 109:271-284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47ceb6588c06832f24403858790d6b33
https://doi.org/10.1016/j.bbi.2023.02.002
https://doi.org/10.1016/j.bbi.2023.02.002
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
The family of lipid neuromodulators has been rapidly growing, as the use of different -omics techniques led to the discovery of a large number of naturally occurring N-acylethanolamines (NAEs) and N-acyl amino acids belonging to the complex lipid sig
Externí odkaz:
https://doaj.org/article/e51848c7a8634ee1b0d65bc5f332eb1e
Autor:
Paola Devoto, Claudia Sagheddu, Michele Santoni, Giovanna Flore, Pierluigi Saba, Marco Pistis, Gian Luigi Gessa
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from no
Externí odkaz:
https://doaj.org/article/105abd9b3d114562a0534b0f678f649f
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1025 (2021)
Common pathophysiological mechanisms have emerged for different neurological and neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, and altered metabolic pathways converge and cause neuronal and non-neuro
Externí odkaz:
https://doaj.org/article/31e96b9094d44fafa12530ec41438464