Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Claudia, Pitzer"'
Autor:
Aynur Sönmez, Rasem Mustafa, Salome T. Ryll, Francesca Tuorto, Ludivine Wacheul, Donatella Ponti, Christian Litke, Tanja Hering, Kerstin Kojer, Jenniver Koch, Claudia Pitzer, Joachim Kirsch, Andreas Neueder, Grzegorz Kreiner, Denis L. J. Lafontaine, Michael Orth, Birgit Liss, Rosanna Parlato
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The
Externí odkaz:
https://doaj.org/article/ef5389a9059145348fc5353ee8922ca1
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The automatization of behavioral tests assessing motor activity in rodent models is important for providing robust and reproducible results and evaluating new therapeutics. The CatWalk system is an observer-independent, automated and compute
Externí odkaz:
https://doaj.org/article/a1bd32eaad274e71b47a7dfbe9070096
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Neuropsychiatric disorders are often associated with motor and coordination abnormalities that have important implications on the etiology, pathophysiology, and management of these disorders. Although the onset of many neuropsychiatric disor
Externí odkaz:
https://doaj.org/article/15166315504f4f39a266e2e0a2b11553
Autor:
Anke Tappe-Theodor, Claudia Pitzer, Lars Lewejohann, Paulin Jirkof, Katja Siegeler, Astra Segelcke, Natascha Drude, Bruno Pradier, Esther Pogatzki-Zahn, Britta Hollinderbäumer, Daniel Segelcke
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The prospective severity assessment in animal experiments in the categories' non-recovery, mild, moderate, and severe is part of each approval process and serves to estimate the harm/benefit. Harms are essential for evaluating ethical justifiability,
Externí odkaz:
https://doaj.org/article/6710302be71640a7b86a5a4dfea7f037
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Depression affects women nearly twice as frequently as men. In contrast, rodent models of depression have shown inconsistent results regarding sex bias, often reporting more depression-like behaviors in males. This sex discrepancy in rodents modeling
Externí odkaz:
https://doaj.org/article/6bf7288ce1d74077a3bb61d48fabba3c
Autor:
Johannes Flamm, Sunniva Hartung, Stella Gänger, Frank Maigler, Claudia Pitzer, Katharina Schindowski
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
We have recently developed a region-specific catheter-based intranasal application method in mice by using CT scan-based 3D cast models of the murine nose (DOI: 10.2376/0005-9366-17,102). This technique is able to specifically deliver drugs to the ol
Externí odkaz:
https://doaj.org/article/911d3f3e3d24433c9eec52c2dfba17db
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Depression is a major neuropsychiatric disorder, decreasing the ability of hundreds of millions of individuals worldwide to function in social, academic, and employment settings. Beyond the alarming public health problem, depression leads to morbidit
Externí odkaz:
https://doaj.org/article/584d53d905a94bfaa6245229da8e031f
Publikováno v:
eLife, Vol 9 (2020)
Core facilities are an effective way of making expensive experimental equipment available to a large number of researchers, and are thus well placed to contribute to efforts to promote good research practices. Here we report the results of a survey t
Externí odkaz:
https://doaj.org/article/c5f6e165c91a43a39203b27e9b16ca74
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-23 (2018)
Abstract Background The tetraspanins Tspan8 and CD151 promote metastasis, exosomes (Exo) being suggested to be important in the crosstalk between tumor and host. The contribution of Tspan8 and CD151 to host versus tumor-derived exosome (TEX) activiti
Externí odkaz:
https://doaj.org/article/715e889d14e4487e83c52b4ce79a387c
Autor:
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1904 (2021)
Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents. Thus, the lack of a precise and region-sp
Externí odkaz:
https://doaj.org/article/9cc3636f978846548c41bf6687931047