Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Claudia, Paret"'
Autor:
Arsenij Ustjanzew, Annekathrin Silvia Nedwed, Roger Sandhoff, Jörg Faber, Federico Marini, Claudia Paret
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Background Glycosphingolipids (GSLs) are membrane lipids composed of a ceramide backbone linked to a glycan moiety. Ganglioside biosynthesis is a part of the GSL metabolism, which involves sequential reactions catalyzed by specific enzymes t
Externí odkaz:
https://doaj.org/article/6c5814a3e6e648e095480b746037ea8d
Autor:
Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTDespite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to accou
Externí odkaz:
https://doaj.org/article/2b706a5b32624427bf13e1bdcb10eeb5
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Arsenij Ustjanzew, Alexander Desuki, Christoph Ritzel, Alina Corinna Dolezilek, Daniel-Christoph Wagner, Jan Christoph, Philipp Unberath, Thomas Kindler, Jörg Faber, Federico Marini, Torsten Panholzer, Claudia Paret
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Extensive sequencing of tumor tissues has greatly improved our understanding of cancer biology over the past years. The integration of genomic and clinical data is increasingly used to select personalized therapies in dedicated tu
Externí odkaz:
https://doaj.org/article/1fdb8149674344e5b4c3f22c5f6dc34d
Autor:
Nadine Lehmann, Claudia Paret, Khalifa El Malki, Alexandra Russo, Marie Astrid Neu, Arthur Wingerter, Larissa Seidmann, Sebastian Foersch, Nicole Ziegler, Lea Roth, Nora Backes, Roger Sandhoff, Joerg Faber
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer. Tumor cells can be recognized and killed
Externí odkaz:
https://doaj.org/article/e138c3c0e30c4a50b0b943bb2fc60865
Autor:
Sandra Stössel, Marie A. Neu, Arthur Wingerter, Wilhelm Bloch, Philipp Zimmer, Claudia Paret, Khalifa El Malki, Freerk T. Baumann, Alexandra Russo, Nicole Henninger, Nadine Lehmann, Henrike Otto, Jörg Faber
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Objective: In cancer patients, the impairment in muscle function is a frequently observed phenomenon. However, comprehensive evaluation of the effect of exercise training on muscle function in childhood cancer patients (CCPs) is sparse and therefore
Externí odkaz:
https://doaj.org/article/4c37caae9ca7403baef8bdd3b80d3a74
Autor:
Faber, Khalifa El Malki, Pia Wehling, Francesca Alt, Roger Sandhoff, Sebastian Zahnreich, Arsenij Ustjanzew, Carolin Wilzius, Marc A. Brockmann, Arthur Wingerter, Alexandra Russo, Olaf Beck, Clemens Sommer, Malte Ottenhausen, Katrin B. M. Frauenknecht, Claudia Paret, Jörg
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9905
H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies. We tested the effect of the glucosylcerami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d06971d15320f33efa010e3dfe7f51d3
Autor:
Ugur Sahin, Özlem Türeci, Karl Dhaene, Claudia Paret, Cedrik M. Britten, Abdo Konur, Sebastian Attig, Sebastian Kreiter, Lisa Hebich, Andrea Breitkreuz, Tana A. Omokoko, Petra Simon
Supplementary Table S1. Primers used in this study. Supplementary Table S2. A/B Coverage of TCR-α (A) and TCR-β (B) variable genes with clonotype-specific primers. Supplementary Table S3. Characteristics of cloned TCRs. Supplementary Figure S4. Flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d243fb2715d613307a06202fd241318e
https://doi.org/10.1158/2326-6066.22536782
https://doi.org/10.1158/2326-6066.22536782
Autor:
Ugur Sahin, Özlem Türeci, Karl Dhaene, Claudia Paret, Cedrik M. Britten, Abdo Konur, Sebastian Attig, Sebastian Kreiter, Lisa Hebich, Andrea Breitkreuz, Tana A. Omokoko, Petra Simon
The determination of the epitope specificity of disease-associated T-cell responses is relevant for the development of biomarkers and targeted immunotherapies against cancer, autoimmune, and infectious diseases. The lack of known T-cell epitopes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bc6adaff61824905bdd6aa52645f97
https://doi.org/10.1158/2326-6066.c.6548237.v1
https://doi.org/10.1158/2326-6066.c.6548237.v1
Autor:
Margot Zöller, Leonie K. Ashman, Dorothee Herlyn, Osamu Yoshie, Vaclav Horejsi, Friedrich H. Schmitz-Winnenthal, Kaspar Zgraggen, Jürgen Weitz, Dagmar Hildebrand, Claudia Paret, Sabine Gesierich
Supplementary Tables 1-3 from Colocalization of the Tetraspanins, CO-029 and CD151, with Integrins in Human Pancreatic Adenocarcinoma: Impact on Cell Motility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837060f894372821651e6a647bb2bebc
https://doi.org/10.1158/1078-0432.22441620.v1
https://doi.org/10.1158/1078-0432.22441620.v1