Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Claudia, Generaux"'
Publikováno v:
Journal of Investigative Surgery, Vol 35, Iss 3, Pp 502-510 (2022)
Background: Biologic therapeutics constitute up to 30% of all drugs approved from 2010 to 2018 and represent a continuous growing market. In contrast to small molecules, biologic therapeutics (>1 kDa MW) are administered parenterally or intravenously
Externí odkaz:
https://doaj.org/article/35037ae1eb7a4f2eab6a8a9e7cc4851c
Autor:
Wei Meng, Heather Finlay, Claudia Generaux, Chiuwa E. Luk, Tao Wang, Robert Paul Brigance, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, William A. Schumacher, Jeffrey S. Bostwick, Zulan Pi, Karen A. Rossi
Publikováno v:
Journal of Medicinal Chemistry. 64:18102-18113
This paper describes our continued efforts in the area of small-molecule apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated monodemethylation of the dimethoxyphenyl group to generate atro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f63d50e642c7389207d1baa0094a005
https://doi.org/10.1021/acs.jmedchem.1c01504
https://doi.org/10.1021/acs.jmedchem.1c01504
Autor:
Jeremy M. Richter, J. Alex Bates, Peter Gargalovic, Joelle M. Onorato, Claudia Generaux, Tao Wang, David A. Gordon, Ruth R. Wexler, Heather J. Finlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Agonism of the apelin receptor (APJ) has demonstrated beneficial effects in models of heart failure. We have previously disclosed compounds such as 4, which showed good APJ agonist activity but were metabolized to the mono-demethylated, non-interconv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898309a657734b060ea109a87904cf66
https://pubmed.ncbi.nlm.nih.gov/35817293
https://pubmed.ncbi.nlm.nih.gov/35817293
Autor:
William A. Schumacher, Yan He, Peter S. Gargalovic, Tao Wang, Joelle M. Onorato, Ruth R. Wexler, James A. Johnson, Zulan Pi, Claudia Generaux, Wei Meng, Heather Finlay, David A. Gordon, Monique Phillips, Jeffrey S. Bostwick
Publikováno v:
ACS Med Chem Lett
[Image: see text] The apelin receptor (APJ) is a significant regulator of cardiovascular function and is involved in heart failure and other cardiovascular diseases. (Pyr(1))apelin-13 is one of the endogenous agonists of the APJ receptor. Administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c497839aa78ba246784ea2c27101a0c
https://europepmc.org/articles/PMC8591725/
https://europepmc.org/articles/PMC8591725/
Autor:
Claudia Generaux, Heather Finlay, Susan R. Arthur, Mei-Yin Hsu, Roy Haskell, Peter S. Gargalovic, Joelle M. Onorato, Michael Basso, Rongan Zhang, Kimberley A. Lentz, Anne Rose, Carrie Xu, Lei Zhao, Jeffrey S. Bostwick, Gayani Fernando, Ricardo Garcia, Xue-Qing Chen, James Hennan, Michael C. Myers, R. Michael Lawrence, Petia Shipkova, Samuel Hellings
Publikováno v:
Analytical Biochemistry. 568:41-50
Apelin, the endogenous ligand for the APJ receptor, has generated interest due to its beneficial effects on the cardiovascular system. Synthesized as a 77 amino acid preproprotein, apelin is post-translationally cleaved to a series of shorter peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3495dfd08cb3a449d294bfbeddcc9b36
https://doi.org/10.1016/j.ab.2018.12.022
https://doi.org/10.1016/j.ab.2018.12.022
Autor:
Ruth R. Wexler, George O. Tora, Michael Galella, Peter S. Gargalovic, Chiuwa E. Luk, Tao Wang, Claudia Generaux, Joelle M. Onorato, Heather Finlay, Ji Jiang, Carrie Xu, Yan He, Jeffrey S. Bostwick
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Heart failure (HF) treatment remains a critical unmet medical need. Studies in normal healthy volunteers and HF patients have shown that [Pyr1]apelin-13, the endogenous ligand for the APJ receptor, improves cardiac function. However, the short half-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e72e9ac6c537ae90a7108b47977b94b
https://pubmed.ncbi.nlm.nih.gov/34403724
https://pubmed.ncbi.nlm.nih.gov/34403724
Autor:
Heather Finlay, Claudia Generaux, Carrie Xu, Chiuwa E. Luk, Ruth R. Wexler, Ji Jiang, James A. Johnson, Michael Galella, Jeffrey S. Bostwick, William A. Schumacher, Tao Wang, Monique Phillips, Soong-Hoon Kim, Yan He, Joelle M. Onorato, Peter S. Gargalovic, Xue-Qing Chen, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 64(6)
Apelin-13 is an endogenous peptidic agonist of the apelin receptor (APJ) receptor with the potential for improving cardiac function in heart failure patients. However, the low plasma stability of apelin-13 necessitates continuous intravenous infusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa7bda554f3c76e0159bb8b5f189ed9
https://pubmed.ncbi.nlm.nih.gov/33689340
https://pubmed.ncbi.nlm.nih.gov/33689340
Autor:
Carrie Xu, Stéphane St-Onge, Ruth R. Wexler, Heather Finlay, Earl J. Crain, David A. Gordon, Tao Wang, Joelle M. Onorato, Michel Bouvier, Claudia Generaux, Peter S. Gargalovic, Xue-Qing Chen, Madeleine Héroux, Pancras C. Wong, Michael R. Lawrence, Mujing Yan
Publikováno v:
Circulation. Heart Failure
Supplemental Digital Content is available in the text.
Background: New heart failure therapies that safely augment cardiac contractility and output are needed. Previous apelin peptide studies have highlighted the potential for APJ (apelin recept
Background: New heart failure therapies that safely augment cardiac contractility and output are needed. Previous apelin peptide studies have highlighted the potential for APJ (apelin recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed02c243fd81b6ab1dc4a94f1ec6e6b
https://doi.org/10.1161/circheartfailure.120.007351
https://doi.org/10.1161/circheartfailure.120.007351
Publikováno v:
Journal of investigative surgery : the official journal of the Academy of Surgical Research. 35(3)
Background: Biologic therapeutics constitute up to 30% of all drugs approved from 2010 to 2018 and represent a continuous growing market. In contrast to small molecules, biologic therapeutics (>1 k...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c027a0d3fa2ddcca21bc0d0a1064f0
https://pubmed.ncbi.nlm.nih.gov/33622163
https://pubmed.ncbi.nlm.nih.gov/33622163
Autor:
Xizhe Gao, Gerard Dalglish, Leonid Kagan, Claudia Generaux, Raymond Rosa, Alexander T. Kozhich, Gregory Voronin, Sarah Oh, Anne Rose
Publikováno v:
Pharmaceutical Research. 37
The purpose of this work was to investigate the role of the lymphatic system in the pharmacokinetics of etanercept, a fusion protein. Etanercept 1 mg/kg was administered intravenously (IV) and subcutaneously (SC) to thoracic lymph duct-cannulated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fed24ae4b0822d749f1bd3e474fda07
https://doi.org/10.1007/s11095-020-02860-6
https://doi.org/10.1007/s11095-020-02860-6