Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Claudette Bethune"'
1
Akademický článek
Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD
Autor: Michael Walsh, Claudette Bethune, Andrew Smyth, Jessica Tyrwhitt, Shiangtung W. Jung, Rosie Z. Yu, Yanfeng Wang, Richard S. Geary, Jeffrey Weitz, Sanjay Bhanot
Publikováno v: Kidney International Reports, Vol 7, Iss 2, Pp 200-209 (2022)
Introduction: Patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) have an increased risk of thrombotic events and bleeding. Antisense reduction of factor XI (FXI) with IONIS-FXIRx is a novel strategy that may safely reduce the ri
Externí odkaz: https://doaj.org/article/9d5c672fdff6474baf02354f5b056319
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2
Akademický článek
PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients
Autor: Stefan Willmann, Eleonora Marostica, Nelleke Snelder, Alexander Solms, Markus Jensen, Maximilian Lobmeyer, Anthonie W. A. Lensing, Claudette Bethune, Erin Morgan, Rosie Z. Yu, Yanfeng Wang, Shiangtung W. Jung, Richard Geary, Sanjay Bhanot
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 890-901 (2021)
Abstract IONIS‐FXIRX (BAY2306001) is an antisense oligonucleotide that inhibits the synthesis of coagulation factor XI (FXI) and has been investigated in healthy volunteers and patients with end‐stage renal disease (ESRD). FXI‐LICA (BAY2976217)
Externí odkaz: https://doaj.org/article/a0f07a9e368749df85e58f6529f928d9
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3
Akademický článek
A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans
Autor: Nicholas R Jones, Melissa A Pegues, Mark A McCrory, Walter Singleton, Claudette Bethune, Brenda F Baker, Daniel A Norris, Rosanne M Crooke, Mark J Graham, Alexander J Szalai
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Observational studies of patients with established rheumatoid arthritis (RA) document a positive correlation between C-reactive protein (CRP) blood concentration and worsening of RA symptoms, but whether this association is causal or not is not known
Externí odkaz: https://doaj.org/article/392f92544a1e404c948aadef7b9151a7
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4
PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients
Autor: Sanjay Bhanot, Eleonora Marostica, Maximilian Lobmeyer, Nelleke Snelder, Erin E. Morgan, Anthonie W. A. Lensing, Richard S. Geary, Markus Jensen, Shiangtung W. Jung, Yanfeng Wang, Rosie Z. Yu, Stefan Willmann, Claudette Bethune, Alexander Solms
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 890-901 (2021)
CPT: Pharmacometrics & Systems Pharmacology
IONIS‐FXIRX (BAY2306001) is an antisense oligonucleotide that inhibits the synthesis of coagulation factor XI (FXI) and has been investigated in healthy volunteers and patients with end‐stage renal disease (ESRD). FXI‐LICA (BAY2976217) shares t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c833bb12274e461ae57144f261c44b4
https://doaj.org/article/a0f07a9e368749df85e58f6529f928d9
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5
Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXI
Autor: Michael, Walsh, Claudette, Bethune, Andrew, Smyth, Jessica, Tyrwhitt, Shiangtung W, Jung, Rosie Z, Yu, Yanfeng, Wang, Richard S, Geary, Jeffrey, Weitz, Sanjay, Bhanot
Publikováno v: Kidney international reports. 7(2)
Patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) have an increased risk of thrombotic events and bleeding. Antisense reduction of factor XI (FXI) with IONIS-FXIThis multicenter study enrolled 49 patients receiving HD in 2 part
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae4aa5ef679c132fcc18ff3e3bf48d6
https://pubmed.ncbi.nlm.nih.gov/35155859
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6
Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model
Autor: Yanfeng Wang, Scott P. Henry, Sanjay Bhanot, Erin S. Morgan, Kenneth T. Luu, Lynnetta Watts, Richard S. Geary, Claudette Bethune, Anne Smith
Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 44:179-191
IONIS-GCGRRx (ISIS 449884) is an antisense oligonucleotide inhibitor of the glucagon receptor (GCGR). The objective of this study was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of IONIS-GCGRRx via population-based modeling. The o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7636f110567fa6059b9e232b4ca520df
https://doi.org/10.1007/s10928-017-9505-5
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7
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
Autor: Harry R, Büller, Claudette, Bethune, Sanjay, Bhanot, David, Gailani, Brett P, Monia, Gary E, Raskob, Annelise, Segers, Peter, Verhamme, Jeffrey I, Weitz, V, Sulyma
Publikováno v: New England journal of medicine, 372(3), 232-240. Massachussetts Medical Society
BACKGROUND: Patients undergoing total knee arthroplasty are at risk for postoperative venous thromboembolism (VTE). The pathogenesis of postoperative VTE is incompletely understood, but tissue factor exposed at the surgical site is thought to be the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aec86abe8a19b50395b25f9db5a003
https://doi.org/10.1056/nejmoa1405760
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9
A preliminary comparison of polybrominated diphenyl ether concentrations relative to lipid content and to levels of dioxins and dioxin-like polychlorinated biphenyls in Norwegian farmed Atlantic salmon (Salmo salar)
Autor: Kåre Julshamn, Anne-Katrine Lundebye, Claudette Bethune
Publikováno v: International Journal of Food Science and Technology. 40:143-148
Summary Polybrominated diphenyl ethers (PBDEs) are environmental contaminants structurally similar to polychlorinated biphenyls (PCBs), and correlations between PBDE concentrations and concentrations of lipid, PCBs, dioxins and furans in feed and far
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::546b2548579488842ba05c114e89ef69
https://doi.org/10.1111/j.1365-2621.2004.00922.x
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10
Dietary intake of differently fed salmon: a preliminary study on contaminants
Autor: Anne-Katrine Lundebye, Claudette Bethune, I Seljeflot, Livar Frøyland, Helle Margrete Meltzer, Oddmund Johansen, Arnesen H, S L Seierstad, Grethe Rosenlund
Publikováno v: European journal of clinical investigation. 36(3)
Background In a previous study, a group of coronary heart disease (CHD) patients exhibited positive cardioprotective effects of fatty acids derived from a diet of farmed Atlantic salmon fed fish oil (Seierstad et al. 2005). This follow-up study exami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3703cc557f33b922db16b5839a3db687
https://pubmed.ncbi.nlm.nih.gov/16506965
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