Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Claude Thal"'
Autor:
Daniel Guenard, Joel L. Sussman, Bernard Badet, Harry M. Greenblatt, Israel Silman, Simone A. Botti, Anat Argaman, Claude Thal, Catherine Guillou
Publikováno v:
Scopus-Elsevier
Bifunctional derivatives of the alkaloid galanthamine, designed to interact with both the active site of the enzyme acetylcholinesterase (AChE) and its peripheral cation binding site, have been assayed with Torpedo californica AChE (TcAChE), and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a5b237a6a3822295ad850ad86f4ca1
https://doi.org/10.1021/ja0466154
https://doi.org/10.1021/ja0466154
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 27:185-195
The present study was designed to investigate whether a combination of a new acetylcholinesterase inhibitor we have synthesized, galanthaminium bromide, and an agonist of 5-hydroxytryptamine 4 receptors, RS 67333, at doses ineffective alone, improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74295c976253f74065dd51fc960ea542
https://doi.org/10.1016/s0278-5846(02)00351-2
https://doi.org/10.1016/s0278-5846(02)00351-2
Publikováno v:
Tetrahedron Letters. 41:5853-5856
The synthesis of a di-nor-secorhazinilam analogue is described. This phenylpyrrole compound has beenprepared by a Susuki cross-coupling reaction between 1,2,5 trisubstituted pyrrole halides and 2-N-(tert-butoxycarbonyl)aminophenyl boronic acid. In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c27110d806a55ffcb13ba88898b519
https://doi.org/10.1016/s0040-4039(00)00983-7
https://doi.org/10.1016/s0040-4039(00)00983-7
Publikováno v:
Tetrahedron. 56:2683-2692
Tetrahydro-β-carbolines have been prepared in a diastereomerically pure form by a short, efficient synthetic sequence consisting of reaction of α-aminoaldehydes with tryptamine. A study was made of the major factors affecting the stereoselectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43273bb16915ab1d7917adc630dacef
https://doi.org/10.1016/s0040-4020(00)00165-4
https://doi.org/10.1016/s0040-4020(00)00165-4
Autor:
Claude Thal, Pierre Ducrot
Publikováno v:
Tetrahedron Letters. 40:9037-9040
trans 1-Aminoindolo[2,3-a]quinolizidines were synthesised using an intramolecular Pictet-Spengler-like reaction. Starting from commercially available N-Cbz- l -glutamic acid, indoloquinolizidines were obtained in only five steps with good yields. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22240476679412efdb77f8b199b55124
https://doi.org/10.1016/s0040-4039(99)01922-x
https://doi.org/10.1016/s0040-4039(99)01922-x
Publikováno v:
Tetrahedron Letters. 40:8355-8358
The reaction of neutral 1-substituted-tricarbonyl(η4-4-methoxycyclohexa-1,3-diene)iron complexes 3 with thallium(III) trifluoroacetate in alcoholic solution leads to the corresponding new 4-substituted-tricarbonyl(η4-cyclohexa-2,4-dien-1-one)iron c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac384481f71968d235597aac2afe44c
https://doi.org/10.1016/s0040-4039(99)01725-6
https://doi.org/10.1016/s0040-4039(99)01725-6
Publikováno v:
Tetrahedron Letters. 40:4331-4334
Reaction of p-anisidine 13 or p-bromo orthoanisidine 14 with the new bi-deuterated dienyl complex 12 bearing a leaving group on its side chain affords the mono-deuterated 18a, 19a and the non-deuterated 18b and 19b spiro[1,2,3,4-tetrahydroquinoline-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df567731ab19381fcbb4b5db56a4a46d
https://doi.org/10.1016/s0040-4039(99)00787-x
https://doi.org/10.1016/s0040-4039(99)00787-x
Publikováno v:
Tetrahedron Letters. 39:4251-4254
Galanthamine N-oxide 2 undergoes a Polonovski-Potier reaction to give the iminium salt 5 and the unexpected 8-hydroxygalanthamine 3. An intramolecular oxygen transfer is proposed to explain hydroxylation of the aromatic nucleus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef011361778c5152aade0d56a267864
https://doi.org/10.1016/s0040-4039(98)00695-9
https://doi.org/10.1016/s0040-4039(98)00695-9
Publikováno v:
Tetrahedron. 53:12553-12564
Chelated dicarbonyl (η4-4-methoxycyclohexadiene) iron complexes 6 and 15 which possess a phosphinite and a phosphine bridge respectively form a new class of iron complexes. Their cations 5 and 16 reacted regioselectively with nucleophiles in good yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efcd49e0854f3f81619855a74d5889c1
https://doi.org/10.1016/s0040-4020(97)00776-x
https://doi.org/10.1016/s0040-4020(97)00776-x
Autor:
Marie-Madeleine Portier, Claude Thal, Monique Sensenbrenner, Catherine Quirosa-Guillou, Michel Escurat, Brigitte Pettmann
Publikováno v:
Neuroscience Letters. 230:167-170
A series of substances (designated CTQ compounds) with a guanidine group have been synthesized and tested for their ability to promote neuronal survival and neurite outgrowth. Mouse neuroblastoma clonal cell lines grown in serum-containing medium for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2033e59ddcb81633649306a457d360
https://doi.org/10.1016/s0304-3940(97)00506-5
https://doi.org/10.1016/s0304-3940(97)00506-5