A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

Autor: Phanramphoei N. Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Samaporn Teeravechyan, Anan Jongkaewwattana, Emmanuelle Billon-Denis, Jean-Nicolas Tournier, Matthieu Prot, Laurine Levillayer, Laurine Conquet, Xavier Montagutelli, Magali Tichit, David Hardy, Priyanka Fernandes, Hélène Strick-Marchand, James Di Santo, Etienne Simon-Lorière, Hervé Bourhy, Frédéric Tangy

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro.

Externí odkaz: https://doaj.org/article/5eea106784d445baadd6d500eadbdebc

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

Autor: Samira Khiar, Marianne Lucas-Hourani, Sébastien Nisole, Nikaïa Smith, Olivier Helynck, Maryline Bourgine, Claude Ruffié, Jean-Philippe Herbeuval, Hélène Munier-Lehmann, Frédéric Tangy, Pierre-Olivier Vidalain

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we developed a

Externí odkaz: https://doaj.org/article/ce16c14d2bc5493eb793e1d6481ee255

The role of myelin in Theiler's virus persistence in the central nervous system.

Autor: Jean-Pierre Roussarie, Claude Ruffié, Michel Brahic

Publikováno v: PLoS Pathogens, Vol 3, Iss 2, p e23 (2007)

Theiler's virus, a picornavirus, persists for life in the central nervous system of mouse and causes a demyelinating disease that is a model for multiple sclerosis. The virus infects neurons first but persists in white matter glial cells, mainly olig

Externí odkaz: https://doaj.org/article/110997b6ed9441bc8aa6d8f66c6e1a8c

A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques

Autor: Nathalie Dereuddre-Bosquet, Géraldine Schlecht-Louf, Patrycja Nzounza, Roger Le Grand, Valérie Najburg, Grégoire Martin, Chantal Combredet, Christiane Moog, Gérard Pierron, Thierry Heidmann, Frédéric Tangy, Leslie Gosse, Sylvie Souquere, Claude Ruffié, Caroline Petitdemange

Publikováno v: NPJ vaccines
NPJ vaccines, Nature Research 2021, 6 (1), pp.123. ⟨10.1038/s41541-021-00385-6⟩
NPJ vaccines, 2021, 6 (1), pp.123. ⟨10.1038/s41541-021-00385-6⟩
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)

Replicative vectors derived from live-attenuated measles virus (MV) carrying additional non-measles vaccine antigens have long demonstrated safety and immunogenicity in humans despite pre-existing immunity to measles. Here, we report the vaccination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a0fb232338dbd0eab55d5bc50bebbf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03421041/file/s41541-021-00385-6.pdf

Strong antigen-specific T-cell immunity induced by a recombinant human TERT measles virus vaccine and amplified by a DNA/viral vector prime boost in IFNAR/CD46 mice

Autor: Frédéric Tangy, Thierry Huet, Pierre Langlade-Demoyen, Christelle Liard, Marion Julithe, Marie Escande, Chantal Combredet, Jessie Thalmensi, Simon Wain-Hobson, Elodie Pliquet, Claude Ruffié, Thomas Bestetti, Valérie Najburg

Publikováno v: Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, 2019, 68 (4), pp.533-544. ⟨10.1007/s00262-018-2272-3⟩
Cancer Immunology, Immunotherapy, Springer Verlag, 2019, 68 (4), pp.533-544. ⟨10.1007/s00262-018-2272-3⟩

International audience; Cancer immunotherapy is seeing an increasing focus on vaccination with tumor-associated antigens (TAAs). Human telomerase (hTERT) is a TAA expressed by most tumors to overcome telomere shortening. Tolerance to hTERT can be eas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044afa53550131a805a172fa5811146
https://hal-pasteur.archives-ouvertes.fr/pasteur-03232227