Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Claude Paoletti"'
Autor:
Lukasz Kaczmarek, Marian Mordarski, Jean-Marie Saucier, Peczyńska-Czoch W, François Pognan, Paweł Nantka-Namirski, Claude Paoletti
Publikováno v:
Scopus-Elsevier
The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5 H -indolo[2,3- b ]quinoline, is able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA breaks in BPV I episome in rat fibroblasts. Cytotoxicity studies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3216c053caf7f83ede941dc6be2df0a
https://doi.org/10.1016/0006-2952(92)90341-f
https://doi.org/10.1016/0006-2952(92)90341-f
Autor:
Jean Louis Imbach, Jan Balzarini, Gilles Gosselin, Christian Auclair, E. De Clercq, Claude Paoletti, D Mrani
Publikováno v:
European Journal of Medicinal Chemistry. 26:481-488
A series of bifunctional molecules have been synthesized which result from the combination of a DNA sequence-specific ligand (netropsin) coupled to an intercalator moiety (OPC). The binding constants to double-stranded polynucleotides as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d58150e2c194c4f0c8607059839776
https://doi.org/10.1016/0223-5234(91)90143-b
https://doi.org/10.1016/0223-5234(91)90143-b
Autor:
Bernard Rayner, Christian Auclair, P Le Ber, Françoise Debart, Gilles Gosselin, Jean Louis Imbach, Jan Balzarini, E. De Clercq, Claude Paoletti
Publikováno v:
European Journal of Medicinal Chemistry. 26:261-271
A series of oligo- meta -benzamides structurally related to the natural agent netropsin have been synthesized. Their binding constants to double-stranded polynucleotides as well as their cytostatic activity against tumor cell lines and their in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16faa8060098c376db8502c17b6afafa
https://doi.org/10.1016/0223-5234(91)90058-u
https://doi.org/10.1016/0223-5234(91)90058-u
Autor:
Gilles Gosselin, Jacques Paoletti, Frédéric Subra, Jeanne Pager, Jean Louis Imbach, D Mrani, S. Carteau, Claude Paoletti, Christian Auclair
Publikováno v:
Biochemistry. 30:1642-1650
We have investigated some properties related to interaction with DNA and recognition of AT-rich sequences of netropsin-oxazolopyridocarbazole (Net-OPC) (Mrani et al., 1990), which is a hybrid groove-binder-intercalator. The hybrid molecule Net-OPC bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e975961d6b568e2457afea4fd6adc869
https://doi.org/10.1021/bi00220a029
https://doi.org/10.1021/bi00220a029
Autor:
Michel Baron, Ghanem Atassi, Sylviane Giorgi-Renault, Marie Christine Bissery, Jean Renault, François Lavelle, Patricia Gebel-Servolles, Claude Paoletti, Suzanne Cros
Publikováno v:
Journal of Medicinal Chemistry. 34:38-46
A series of heterocyclic quinones, 6-substituted and 6,7-disubstituted 4-(alkylamino)-5,8-quinazolinediones, have been synthesized in order to evaluate their in vitro cytotoxicity on L1210 leukemia cells. Among 14 derivatives that have been prepared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9028cacd8244e6d52c230cf98f450d2a
https://doi.org/10.1021/jm00105a007
https://doi.org/10.1021/jm00105a007
Publikováno v:
Nucleic Acids Research. 19:2861-2868
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322 DNA was shown previously to depend upon the nature of the drug (Tewey et al. (1984) Science 226, 466-468). The position i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3756c9194c04de5e16291fdfd9fb46
https://doi.org/10.1093/nar/19.11.2861
https://doi.org/10.1093/nar/19.11.2861
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:73-76
Electrochemotherapy delivers external electric pulses to the tumour site to induce local potentiation of the antitumour activity of intramuscular injections of bleomycin. C3H/Bi mice with spontaneous mammary carcinomas received weekly injections of 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf4ab4229dfddd021ca595a59faa96a
https://doi.org/10.1016/0277-5379(91)90065-l
https://doi.org/10.1016/0277-5379(91)90065-l
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:68-72
In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing subcutaneous transplanted tumours were treated with intramu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681b6097a3837ae26f2c73a888001136
https://doi.org/10.1016/0277-5379(91)90064-k
https://doi.org/10.1016/0277-5379(91)90064-k
Autor:
Jean-Marie Saucier, Brigitte René, Philippe Fossé, Claude Paoletti, Chi Hung Nguyen, Emile Bisagni
Publikováno v:
Biochemical Pharmacology. 39:669-676
gamma-Carbolines are tricyclic aromatic compounds which intercalate into DNA base pairs and exhibit significant cytotoxic and antitumor activities. These compounds which are structurally related to ellipticine by deletion of an aromatic ring, induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad23c5a99017a5e3c5e7d250fa271fb
https://doi.org/10.1016/0006-2952(90)90144-a
https://doi.org/10.1016/0006-2952(90)90144-a
Autor:
Jean-Luc Darlix, Chantal Ehresmann, Marylène Mougel, Christine Roy, Jacques Paoletti, Bernard Ehresmann, Claude Paoletti, Naceur Tounekti
Publikováno v:
Scopus-Elsevier
The genome of Moloney murine leukemia virus(MoMuLV) is composed of two identical RNA molecules joined at their 5' ends by the dimer linkage structure (DLS). Recently it was shown that in vitro generated MuLV RNA formed dimeric molecules and that dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14f0c25ed84ac840b67b0734835021a
https://doi.org/10.1093/nar/18.24.7287
https://doi.org/10.1093/nar/18.24.7287