Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Claude P. Selitrennikoff"'
Publikováno v:
Pest Management Science. 65:624-628
BACKGROUND: Macrolide polyene antibiotics possess potent broad-spectrum antifungal properties. Use of these agents in the field or in controlled environments is impeded by their poor water solubility and susceptibility to oxidation- and/or light-indu
Publikováno v:
International Journal of Antimicrobial Agents. 29:103-107
Nucleoside hydrolase (NH) (EC. 3.2.2.3) is an essential enzyme in the purine–pyrimidine salvage pathway utilised by many protozoan parasites and may be a useful drug target. However, the search for NH inhibitors has been hampered by the lack of sui
Publikováno v:
International Journal of Antimicrobial Agents. 28:361-365
Fungal infections of humans and other animals are serious and often life threatening, especially in immunocompromised patients. One difficulty in treating fungal disease is the limited arsenal of antifungal compounds. The recent regulatory approval o
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:474-479
Leishmania major is an important trypanosomatid pathogen that causes leishmaniasis, which is a serious disease in much of the Old World. Current treatments include a small number of antimony compounds that, while somewhat effective, are limited by se
Autor:
Marybeth A. Maligie, Carlos E. Soto, Annette M. Banks, Maureen J. Donlin, Jennifer K. Lodge, Kimberly J. Gerik, Isaac R. Banks, Claude P. Selitrennikoff
Publikováno v:
Molecular Microbiology. 58:393-408
Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival, and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse mutant strains for 10 genes involved in the PKC1 signal tra
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 51:173-178
Turbid growth of some Candida albicans isolates occurs, paradoxically, in some high concentrations of caspofungin, above the minimum inhibitory concentration. We show that the resistant phenotype is first detectable after 24 h of drug exposure. Altho
Publikováno v:
Current Microbiology. 46:408-412
The essential fungal cell-wall polymer (1,3)beta-glucan is synthesized by the enzyme (1,3)beta-glucan synthase. This enzyme, which is the target of the echinocandin and pneumocandin families of fungicidal antibiotics, is a complex composed of at leas
Autor:
Matthew G. Endrizzi, Li-Jun Ma, Ian T. Paulsen, Gregory O. Kothe, David B. Jaffe, David E. A. Catcheside, Edward M. Marcotte, Jonathan Butler, Giuseppe Macino, Matthew S. Sachs, David D. Perkins, Jerome Naylor, Oded Yarden, Nick O. Read, Shunguang Wang, Sarah E. Calvo, Reinhard Engels, J. Andrew Berglund, Nicole Stange-Thomann, Robert L. Metzenberg, Stephan Seiler, Scott Kroken, Seth Purcell, Dmitrij Frishman, Ulrich Schulte, Bruce W. Birren, Dayong Qui, Manolis Kamvysselis, Edward L. Braun, Gregory Jedd, Rodolfo Aramayo, Mary Anne Nelson, Sante Gnerre, Carlo Cogoni, Deborah Bell-Pedersen, Rodger B. Voelker, Chad Nusbaum, David Greenberg, Robert J. Pratt, Gertrud Mannhaupt, Bushra Rehman, Carolyn G. Rasmussen, Colin P.C. DeSouza, Michael Plamann, Weixi Li, Evan Mauceli, Daniel J. Ebbole, Katherine A. Borkovich, William Fitzhugh, Svetlana Krystofova, Peter Ianakiev, Claude P. Selitrennikoff, Stephen A. Osmani, Marc J. Orbach, Alice Roy, Jay C. Dunlap, Donald O. Natvig, Robert Barrett, Stephen Rudd, Louise Glass, James E. Galagan, Cord Bielke, Karen Foley, Alan Radford, John A. Kinsey, Michael Freitag, Chuck Staben, Lisa A. Alex, Alex Zelter, Cydney B. Nielsen, Margaret Werner-Washburne, Serge Smirnov, Timothy Elkins, Michael Kamal, Werner Mewes, Eric S. Lander, Eric U. Selker
Publikováno v:
Nature. 422:859-868
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000
Autor:
T. K. Miller, Claude P. Selitrennikoff, Lisa A. Alex, Melvin I. Simon, Karl V. Clemons, D A Stevens
Publikováno v:
Medical Mycology. 39:69-74
The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these hi
Autor:
JOAN COMBIE, FRED G. ALBERT, KIM VAN TRAN, JESSICA CABRERA, HEIDI J. CORREIRA, YUEHUA GUO, JOHANNA LINDERMUTH, NICOLE RAUERT, WILLIAM GALBRAITH, CLAUDE P. SELITRENNIKOFF
Publikováno v:
The Journal of Antibiotics. 54:56-65
Extracts of the biomasses and fermentation broths of 217 extremophilic microorganisms isolated from a number of locales were screened for antifungal activity using whole-cell and mechanism-based in vitro assays. Importantly, eleven broth extracts had