Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Claude Michel Wischik"'
Publikováno v:
Dementia and Geriatric Cognitive Disorders. 8:288-295
Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149ce18f778151c81ac6ba362d599c19
https://doi.org/10.1159/000106646
https://doi.org/10.1159/000106646
Autor:
Fidel de la Cruz, Marco Antonio Meraz-Ríos, José Luna-Muñoz, Charles Robert Harrington, Claude Michel Wischik, Raúl Mena, Jesús Avila, Sergio Zamudio, Paola Flores-Rodríguez, Benjamín Florán-Garduño
Publikováno v:
Understanding Alzheimer's Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b608bcccf7fc2c49fe5c1affbcf2f1
https://doi.org/10.5772/54228
https://doi.org/10.5772/54228
Autor:
Charles R. Harrington, John H. Xuereb, Daniel William O'Connor, E S Paykel, F A Huppert, Carol Brayne, Claude Michel Wischik, Lin Yang Chi
Publikováno v:
Europe PubMed Central
An increased apolipoprotein E (ApoE) type Ε4 allele frequency is associated with both sporadic and familial late-onset Alzheimer''s disease (AD). The age of onset of disease in patients homozygous for the Ε4 allele appears to be decreased by approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb6753bd0f9eee26fde647acf39067e
https://doi.org/10.1159/000106873
https://doi.org/10.1159/000106873
Publikováno v:
Neuroscience Letters. 202:101-104
Apolipoprotein E type epsilon 4 alleles are increased in both Alzheimer's disease (AD) and cortical Lewy body dementia, while the epsilon 2 allele has been associated as a protective factor against the development of dementia in AD. We have determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce17ca5480b254d2e0424bcd0596722
https://doi.org/10.1016/0304-3940(95)12218-4
https://doi.org/10.1016/0304-3940(95)12218-4
Autor:
Martin Roth, Douglas L. Hauser, Claude Michel Wischik, Charles R. Harrington, William Bondareff
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 54:657-663
Adult human nerve cells contain tau protein, a phosphorylated microtubule-associated protein, that is hyperphosphorylated in the fetus and in patients with Alzheimer's disease. Hyperphosphorylation, which diminishes the microtubule-binding capacity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640b47503ed9345be4a4c10d300de2cf
https://doi.org/10.1097/00005072-199509000-00007
https://doi.org/10.1097/00005072-199509000-00007
Autor:
Charles R. Harrington, Elizabeta B. Mukaetova-Ladinska, Felicia A. Huppert, Robert Y. K. Lai, Martin Roth, Raúl Mena, Claude Michel Wischik, Patricia C. Edwards, John H. Xuereb, Eugene S. Paykel, Carol Brayne, Herman N.-J. Gertz
Publikováno v:
Neurobiology of Aging. 16:409-417
In Alzheimer's disease, there is a major redistribution of the tau protein pool from soluble to PHF-bound forms. PHF-bound tau can be distinguished from normal tau by acid reversible occlusion of a generic tau epitope in the tandem repeat region and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba0f31fb043af2713d1507e715ee2cf
https://doi.org/10.1016/0197-4580(95)97327-d
https://doi.org/10.1016/0197-4580(95)97327-d
Publikováno v:
International Review of Psychiatry. 7:361-383
SummaryAlzheimer's disease is the most common form of dementia, although its diagnosis can only be confirmed after autopsy. While 10% of cases show a family history of the disease, the remainder are sporadic. Disease-causing mutations in three genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22f932087945e24b720fa6db4e5c1d1
https://doi.org/10.3109/09540269509022988
https://doi.org/10.3109/09540269509022988
Publikováno v:
International Review of Psychiatry. 7:399-417
SummaryAlzheimer's disease (AD) is one of the most frequently reported degenerative disorders in the elderly. It is characterized by the gradual accumulation of plaques and tangles. Correlative clinico-neuropathological studies have found a close rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb83942900b98ae103b9276edc29ab5
https://doi.org/10.3109/09540269509022990
https://doi.org/10.3109/09540269509022990
Publikováno v:
Dementia and Geriatric Cognitive Disorders. 6:281-285
An 85-kDa antigen was detected in cerebrospinal fluid (CSF) using a monoclonal antibody, 11.57, raised against a fraction of paired helical filaments extracted from Alzheimer’s disease (AD) brain tissues. The antigen is a thermostable protein that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d521e0ac1663df7e71d97427324685e
https://doi.org/10.1159/000106959
https://doi.org/10.1159/000106959
Publikováno v:
International Review of Psychiatry. 7:299-338
SummaryStudies of Alzheimer's disease have pointed to loss of the normal microtubule associated protein tau and accumulation of pathological paired helical filaments as strong discriminators for cognitive impairment. The most likely explanation is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c187fc8a976f8ef31f8572d76e372b
https://doi.org/10.3109/09540269509022985
https://doi.org/10.3109/09540269509022985