Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Claude Malvy"'
Autor:
Anna Alhaddad, Catherine Durieu, Géraldine Dantelle, Eric Le Cam, Claude Malvy, François Treussart, Jean-Rémi Bertrand
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52207 (2012)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamo
Externí odkaz:
https://doaj.org/article/c9e967c43f8945d880065e5679370630
Autor:
Claude Malvy, Christine Vauthier
Publikováno v:
Nanoparticles for Biotherapeutic Delivery
Joshua D Ramsey; M Laird Forrest. Nanoparticles for Biotherapeutic Delivery, 1, Future Science Ltd, pp.6-21, 2015, 978-1-910420-40-9. ⟨10.4155/fseb2013.14.142⟩
Joshua D Ramsey; M Laird Forrest. Nanoparticles for Biotherapeutic Delivery, 1, Future Science Ltd, pp.6-21, 2015, 978-1-910420-40-9. ⟨10.4155/fseb2013.14.142⟩
International audience; Gene silencing approaches have demonstrated high promise for the development of new treatments of diseases caused by the abnormal overexpression of a known gene. However, the in vivo delivery of the gene silencing mediating ag
Publikováno v:
Delivery Strategies for Antisense Oligonucleotide Therapeutics ISBN: 9781315150901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1120885bf477aabbfd25a83d67e10c1a
https://doi.org/10.1201/9781315150901-15
https://doi.org/10.1201/9781315150901-15
Publikováno v:
Thyroid. 20:1053-1065
RET/PTC1 rearrangement is the most common genetic alteration identified to date in papillary thyroid carcinomas (PTC) and represents an interesting target for small interfering RNA (siRNA) strategies because it is present only in the tumor cells and
Publikováno v:
Pharmaceutical Research. 27:498-509
Purpose. Development of efficient in vivo delivery nanodevices remains a major challenge to achieve clinical application of siRNA. The present study refers to the conception of core-shell nanoparticles aiming to make possible intravenous administrati
Publikováno v:
The Open Nanomedicine Journal. 2:36-45
The EWS-Fli1 fusion gene, resulting from a t(11;22) translocation, plays a key role in the Ewing's sarcoma pathogenesis. In the past, a 25mer phosphorothioate antisense oligodeoxynucleotide, a structured 30mer phos- phorothioate/phosphodiester antise
Publikováno v:
Oligonucleotides. 19:255-264
Oligonucleotides (ONs) such as antisense oligonucleotides (AS-ON) and siRNAs are used as experimental tools to study gene function and are currently being tested in clinical trials for use as therapeutic anticancer agents. However, their therapeutic
Autor:
Miklós Hollósi, Claude Malvy, Gábor Tóth, Sándor Bottka, Orsolya Kiss-Ivánkovits, Jean Remi Bertrand, Tiphanie Auguste, Eszter Illyés, Ilona Laczkó
Publikováno v:
Bioconjugate Chemistry. 20:1307-1314
The ability of different synthetic cell penetrating peptides, as Antennapedia (wild and Phe(6) mutated penetratins), flock house virus, and integrin peptides to form complexes with a 25mer antisense oligonucleotide was compared and their conformation
Autor:
Claude Malvy, Claire Lucas, Catherine Durieu, Patrick Couvreur, Ngoc Minh Pham, Didier Desmaële, Jean-Rémi Bertrand
Publikováno v:
Nucleic acid therapeutics. 25(3)
Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be used to deliver siRNA in cells without covalent binding similar to usual transfection with c
Autor:
Jean-Charles Arnault, Eric Le Cam, Catherine Pioche-Durieu, Tristan Petit, Claude Malvy, François Treussart, Hugues A. Girard, Jean-Rémi Bertrand, Juan Ayala
Publikováno v:
Biomaterials
Biomaterials, Elsevier, 2015, 45, pp.93-98. 〈10.1016/j.biomaterials.2014.12.007〉
Biomaterials, 2015, 45, pp.93-98. ⟨10.1016/j.biomaterials.2014.12.007⟩
Biomaterials, Elsevier, 2015, 45, pp.93-98. ⟨10.1016/j.biomaterials.2014.12.007⟩
Biomaterials, Elsevier, 2015, 45, pp.93-98. 〈10.1016/j.biomaterials.2014.12.007〉
Biomaterials, 2015, 45, pp.93-98. ⟨10.1016/j.biomaterials.2014.12.007⟩
Biomaterials, Elsevier, 2015, 45, pp.93-98. ⟨10.1016/j.biomaterials.2014.12.007⟩
International audience; The expression of a defective gene can lead to major cell dysfunctions among which cell proliferation and tumor formation. One promising therapeutic strategy consists in silencing the defective gene using small interfering RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6c4d26cbb2639d5d69abf5745f8bac
https://hal-cea.archives-ouvertes.fr/cea-01807460
https://hal-cea.archives-ouvertes.fr/cea-01807460