Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Claude Lormeau"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Cells encode information by modulating signal dynamics. Here the authors developed a rapid prototyping tool, TopoDesign, to engineer a synthetic short-pulse decoder in yeast.
Externí odkaz:
https://doaj.org/article/27e1aa2415544771b54c7553953cb088
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background To develop mechanistic dynamic models in systems biology, one often needs to identify all (or minimal) representations of the biological processes that are consistent with experimental data, out of a potentially large set of hypot
Externí odkaz:
https://doaj.org/article/1338c4054eca4d9abd050b9d4b33e24d
Publikováno v:
IFAC-PapersOnLine, 53 (2)
21th IFAC World Congress. Proceedings
21th IFAC World Congress. Proceedings
Deterministic dynamic models play a crucial role in elucidating the function of biological networks. However, the underlying biological mechanisms are often only partially known, and different biological hypotheses on the unknown molecular mechanisms
Publikováno v:
IFAC-PapersOnLine. 50:9871-9876
Computational methods enable the design of synthetic biological circuits demonstrating a specific dynamic behavior. Current methods are based on the assembly of parts characterized in different contexts, which often fail to operate as predicted when
Publikováno v:
Molecular Systems Design & Engineering. 2:410-421
The rational design of synthetic gene circuits has led to many successful applications over the past decade. However, increasingly complex constructs also revealed that analogies to electronics design such as modularity and ‘plug-and-play’ compos
Autor:
Martin Fussenegger, Hui Wang, Mingqi Xie, Claude Lormeau, Jörg Stelling, Pratik Saxena, Haifeng Ye, Ghislaine Charpin-El Hamri
Publikováno v:
Science (New York, N.Y.). 354(6317)
Chronically deregulated blood-glucose concentrations in diabetes mellitus result from a loss of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin sensitivity of body cells and glucose-stimulated insulin release (ty
Autor:
Maurice Petitou, Jean-Marc Herbert, Andre Bernat, Philippe Duchaussoy, Jean-Claude Lormeau, Jean-Pascal Herault, Pierre-Alexandre Driguez
Publikováno v:
Nature. 398:417-422
Unwanted side effects of pharmacologically active compounds can usually be eliminated by structural modifications. But the complex heterogeneous structure of the polysaccharide heparin1 has limited this approach to fragmentation, leading to slightly
Autor:
Jean-Marc Herbert, Jean-Claude Lormeau, Maurice Petitou, Jean-Maurice Mallet, Pierre Sinaÿ, Arnim Helmboldt, Jean-Pascal Herault
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1509-1516
We describe here the synthesis and the biological activity of a ‘C-pentasaccharide’, a new analogue of the antithrombin III (AT III) binding region of heparin containing a methylene bridge in place of an interglycosidic oxygen atom. The affinity
Autor:
Jean-Pascal Herault, Jean-Marc Herbert, Corinne Avril, Paul J. Schaeffer, Françoise Bono, Jean-Claude Lormeau
Publikováno v:
Journal of Cellular Physiology. 172:36-43
The binding of [125I]-factor Xa to human umbilical vein endothelial cell (HUVEC) monolayers was studied. At 7 degrees C, [125I]-factor Xa bound to a single class of binding sites with a dissociation constant value of 6.6 +/- 0.8 nM and a binding site
Publikováno v:
Thrombosis and Haemostasis. 76:005-008
SummaryWe examined the effect of the synthetic pentasaccharide representing the minimal binding site of heparin to antithrombin on the antithrombin-mediated inactivation of factor Vila bound to tissue factor. This effect was compared to the effect of