Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Claude Lechene"'
Autor:
Letao Fan, Shaoxun Wang, Xiaochen He, Ezekiel Gonzalez‐Fernandez, Claude Lechene, Fan Fan, Richard J. Roman
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kid
Externí odkaz:
https://doaj.org/article/2f21f99aa78246ff8039ae69afcdac78
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30576 (2012)
Multi-isotope imaging mass spectrometry (MIMS) associates secondary ion mass spectrometry (SIMS) with detection of several atomic masses, the use of stable isotopes as labels, and affiliated quantitative image-analysis software. By associating image
Externí odkaz:
https://doaj.org/article/d3720284927449c49433fc4e27ed0c67
Autor:
Mark H. Ellisman, Rafael Arrojo e Drigo, Claude Lechene, Martin W. Hetzer, Ranjan Ramachandra, Thomas J. Deerinck, Brandon H. Toyama, Varda Lev-Ram
Publikováno v:
The Journal of Cell Biology
Toyama et al. monitor the replacement of long-lived components of nuclear pore complexes (NPCs) and nucleosomes in postmitotic cells. They describe age mosaicism at the level of chromatin organization and find that NPCs are maintained by piecemeal re
Autor:
Varda Lev-Ram, Martin W. Hetzer, Mark H. Ellisman, Eric A. Bushong, Rafael Arrojo e Drigo, Swati Tyagi, Thomas J. Deerinck, Claude Lechene, Victoria J. Orphan, Sebastien Phan, Ranjan Ramachandra
Publikováno v:
Cell Metab
Most neurons are not replaced during an animal’s lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins. To study the lifespans of cells and proteins in adult tissues, we combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389afbaf4c593425f88f39db7fd83494
https://resolver.caltech.edu/CaltechAUTHORS:20190607-131617878
https://resolver.caltech.edu/CaltechAUTHORS:20190607-131617878
Autor:
Xiaochen He, Richard J. Roman, Letao Fan, Shaoxun Wang, Fan Fan, Claude Lechene, Ezekiel Gonzalez-Fernandez
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Physiological Reports
Physiological Reports
This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kidneys and
Autor:
Swati Tyagi, Martin W. Hetzer, Brandon H. Toyama, Varda Lev-Ram, Claude Lechene, Mark H. Ellisman, Eric A. Bushong, Thomas J. Deerinck, Rafael Arrojo e Drigo, Ranjan Ramachandra
Publikováno v:
Diabetes. 67
We discovered recently that long-lived cells (LLCs), such as neurons, contain long-lived proteins (LLPs) in the nucleus that can last a lifetime, and their decline during aging impairs nuclear function. Beta cells are LLCs with a slow cell replicatio
Autor:
Soomin Kim, Hugues Francois-Saint-Cyr, Mingyue Lun, Claude Lechene, Pouneh K. Fazeli, Matthew L. Steinhauser, Jessica Milian, Evan D. Rosen, Hang Lee, Richard T. Lee, David J. Larson, Jonah P. Zuflacht, Francois Horreard, Christelle Guillermier
Publikováno v:
JCI Insight. 2
Quantification of stable isotope tracers has revealed the dynamic state of living tissues. A new form of imaging mass spectrometry quantifies isotope ratios in domains much smaller than a cubic micron, enabling measurement of cell turnover and metabo
Publikováno v:
Surface and Interface Analysis. 46:169-172
Despite the widely recognized importance of the several species of inositol polyphosphates in cell biology, inositol has not been successfully imaged and quantified inside cells using traditional spectrophotometry. Multi-isotope imaging mass spectrom
Autor:
Mei Wang, Joseph Loscalzo, Shiow-Shih Tang, Claude Lechene, Noriyuki Suzuki, Christelle Guillermier, Joseph Collin Poczatek
Publikováno v:
Surface and Interface Analysis. 46:154-157
Multi-isotope imaging mass spectrometry (MIMS) allows high resolution quantitative imaging of protein and nucleic acid synthesis at the level of a single cell using stable isotope labels. We employed MIMS to determine the compartmental localization o
Publikováno v:
Surface and Interface Analysis. 46:165-168
Multi-isotope imaging mass spectrometry (MIMS) combines stable isotope tracers with the quantitative imaging of NanoSIMS ion microscopy. With extensive safety precedent, use of stable isotopes in MIMS applications opens the possibility of studying a