The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

Autor: Julie Lavie, Claude Lalou, Walid Mahfouf, Jean-William Dupuy, Aurélie Lacaule, Agata Ars Cywinska, Didier Lacombe, Anne-Marie Duchêne, Anne-Aurélie Raymond, Hamid Reza Rezvani, Richard Patryk Ngondo, Giovanni Bénard

Publikováno v: Cell Reports, Vol 42, Iss 6, Pp 112579- (2023)

Summary: In mammals, about 99% of mitochondrial proteins are synthesized in the cytosol as precursors that are subsequently imported into the organelle. The mitochondrial health and functions rely on an accurate quality control of these imported prot

Externí odkaz: https://doaj.org/article/96d6b6a135434edd96cfa4cf212eb723

Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function.

Autor: Kiran Ramgolam, Jessica Lauriol, Claude Lalou, Laura Lauden, Laurence Michel, Pierre de la Grange, Abdel-Majid Khatib, Fawzi Aoudjit, Dominique Charron, Catherine Alcaide-Loridan, Reem Al-Daccak

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18784 (2011)

BackgroundThe aggressiveness of melanoma tumors is likely to rely on their well-recognized heterogeneity and plasticity. Melanoma comprises multi-subpopulations of cancer cells some of which may possess stem cell-like properties. Although useful, the

Externí odkaz: https://doaj.org/article/a36cdd4d0a6a448182064f87b8ed2de0

Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.

Autor: Abdel-Majid Khatib, Rachid Lahlil, Nathalie Scamuffa, Marie-Andrée Akimenko, Sylvain Ernest, Abdderahim Lomri, Claude Lalou, Nabil G Seidah, Bruno O Villoutreix, Fabien Calvo, Geraldine Siegfried

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11438 (2010)

BACKGROUND: In zebrafish, vascular endothelial growth factor-C precursor (proVEGF-C) processing occurs within the dibasic motif HSIIRR(214) suggesting the involvement of one or more basic amino acid-specific proprotein convertases (PCs) in this proce

Externí odkaz: https://doaj.org/article/8ecbc363f84e4cf8b8d1221ab514e263

Lung Tumor Growth Promotion by Tobacco-Specific Nitrosamines Involves the β2-Adrenergic Receptors-Dependent Stimulation of Mitochondrial REDOX Signaling

Autor: Julien Izotte, Efterpi Nikitopoulou, Christian Frezza, Claude Lalou, Hamid Reza Rezvani, Stéphane Claverol, Rodrigue Rossignol, Saharnaz Sarlak, Monica De Luise, Ming Yang, Walid Mahfouf, Nivea Dias Amoedo, Benoit Rousseau, Marcus F. Oliveira, Didier Lacombe, Guiseppe Gasparre, Ana Carolina Bastos Sant'Anna-Silva

Aims: Lung cancer is the leading cause of cancer death worldwide, and tobacco smoking is a recognized major risk factor for lung tumor development. We analyzed the effect of tobacco-specific nitrosamines (TSNAs) on human lung adenocarcinoma metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00155d9b75b1d21ca4ecc514101e9b4a
http://hdl.handle.net/11585/880583

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

Autor: Saharnaz Sarlak, Claude Lalou, Rodrigue Rossignol, Andras T. Meszaros, Helmut Klocker, Christian Frezza, Juan Alberto Pérez-Valencia, Ana Carolina B Sant'Anna-Silva, Erich Gnaiger, Laura Tronci, Efterpi Nikitopoulou, Marco Sciacovelli

Publikováno v: Cancers, Vol 13, Iss 1727, p 1727 (2021)
Cancers
Cancers, MDPI, 2021, 13 (7), pp.1727. ⟨10.3390/cancers13071727⟩
Volume 13
Issue 7
Cancers, 2021, 13 (7), pp.1727. ⟨10.3390/cancers13071727⟩

Simple Summary Depending on the availability of nutrients and increased metabolic demands, tumor cells rearrange their metabolism to survive and, ultimately, proliferate. Here, the authors investigated the effect of succinate, a metabolite of the mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079f13a1872c9a0fb59b0ecedc6fbc0b
https://www.mdpi.com/2072-6694/13/7/1727