Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Claude Godbout"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Yanneve Rolland, Claude Godbout, Hui Ding, Alexandre Bramoullé, Michel O. Steinmetz, Rolf A. Brekken, Patrick G. Harran, Sami Chaaban, Thomas M. Wilkie, Ozhan Ocal, Natacha Olieric, Peter M. Siegel, Anne Roulston, Joseph C. Arezzo, Matthew G. Annis, Gary J. Brouhard, Cynthia Bernier, Mark A. Hancock, Cecilia Rocha, Anita Hall, Andrea E. Prota, Joseph Tcherkezian, Michal Wieczorek, George Zogopoulos, Gordon C. Shore
Publikováno v:
Science translational medicine, vol 8, iss 365
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a6fb17c4299685199025dd72f9ddc
https://escholarship.org/uc/item/9dr6h535
https://escholarship.org/uc/item/9dr6h535
Autor:
William Brown, Kemal Payza, Hong Xiang Liu, Chantevy Pou, Claude Godbout, Pablo Brumovsky, Ralf Schmidt, Tomas Hökfelt, Lejla Hodzic
Publikováno v:
Proceedings of the National Academy of Sciences. 98:9960-9964
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. Here, we describe a generation of a specific galanin R2 (Ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7775abd03b3f5fe0317d9038c07b5b40
https://doi.org/10.1073/pnas.161293598
https://doi.org/10.1073/pnas.161293598
Autor:
Ralf Schmidt, Claude Godbout, Joanne Butterworth, Paul B. S. Clarke, Maryse Labarre, Kemal Payza, Graeme L. Fraser
Publikováno v:
Peptides. 20:1327-1335
AR-M100613 ([I]-Dmt-c[-D-Orn-2-Nal-D-Pro-D-Ala-]) is the iodinated analog of a cyclic casomorphin previously shown to be a potent antagonist at the delta opioid receptor. Specific [125I]AR-M100613 binding to rat whole brain membranes was saturable, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccf9157b10a9d55ba31755546ecec4f
https://doi.org/10.1016/s0196-9781(99)00138-2
https://doi.org/10.1016/s0196-9781(99)00138-2
Autor:
Jean-Marie Pouliot, Claude Godbout
Publikováno v:
The Forestry Chronicle. 74:60-66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca69c581497949ea493fec45b43905c2
https://doi.org/10.5558/tfc74060-1
https://doi.org/10.5558/tfc74060-1
Autor:
Claude Godbout
Publikováno v:
The Forestry Chronicle. 73:341-347
This paper aims at providing the reader with information about the forestry education system in Canada and its trends. As a basis for undertanding the framework of forestry education, a general picture of the Canadian forest sector is drawn and the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6d01299c6edee42e3971ac995ba814
https://doi.org/10.5558/tfc73341-3
https://doi.org/10.5558/tfc73341-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2761-2764
A library of 47 peptidomimetics of YGGFLRFa was prepared wherein 32 of these contained 2,3-methanoleucine. This library was tested for binding the neuropeptide FF receptor where neuropeptide FF is FLFQPQRFa, an anti-opiate peptide. This study illustr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c57de1ea51e59e6646120f72417a6e2
https://doi.org/10.1016/s0960-894x(96)00516-1
https://doi.org/10.1016/s0960-894x(96)00516-1
Autor:
Claude Godbout, Cecilia Rocha, Sami Chabaan, Ozhan Ocal, Yanneve Rolland, Anne Roulston, Gary J. Brouhard, Thomas M. Wilkie, Hui Ding, Gordon C. Shore, Cynthia Bernier, Rolf A. Brekken, Mark A. Hancock, Patrick G. Harran, Natacha Olieric, Andrea E. Prota, Joseph Tcherkezian, Michel O. Steinmetz, Michal Wieczorek
Publikováno v:
Molecular Cancer Therapeutics. 14:A188-A188
Microtubules are critical for cell proliferation, cellular invasion, migration and trafficking. As such, anti-mitotic tubulin binding agents continue to be a cornerstone of adjuvant chemotherapies across many different tumor indications. A major chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a14f274a05d2005838e9efecaab526b
https://doi.org/10.1158/1535-7163.targ-15-a188
https://doi.org/10.1158/1535-7163.targ-15-a188
Autor:
Daniel, Pagé, Elise, Balaux, Luc, Boisvert, Ziping, Liu, Claire, Milburn, Maxime, Tremblay, Zhongyong, Wei, Simon, Woo, Xuehong, Luo, Yun-Xing, Cheng, Hua, Yang, Sanjay, Srivastava, Fei, Zhou, William, Brown, Miroslaw, Tomaszewski, Christopher, Walpole, Leila, Hodzic, Stéphane, St-Onge, Claude, Godbout, Dominic, Salois, Kemal, Payza, Keymal, Payza
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(13)
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38faeba6c5ce18da2d54a009c6fb34
https://pubmed.ncbi.nlm.nih.gov/18522867
https://pubmed.ncbi.nlm.nih.gov/18522867