Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons

Autor: Emmanuel Chautard, Claude Dionet, Pierre Verrelle, Dietrich Averbeck, Bruno Pereira, Geoffroy Marceau, Mélanie Müller-Barthélémy, Andrei Tchirkov, John Gueulette, Jean-Marc Denis, Vincent Sapin

Publikováno v: International Journal of Radiation Biology
International Journal of Radiation Biology, 2016, 92 (9), pp.527-35. ⟨10.1080/09553002.2016.1186300⟩
International Journal of Radiation Biology, Informa Healthcare, 2016, 92 (9), pp.527-35. ⟨10.1080/09553002.2016.1186300⟩

International audience; Purpose: To analyze the dose rate influence in hyper-radiosensitivity (HRS) of human melanoma cells to very low doses of fast neutrons and to compare to the behaviour of normal human skin fibroblasts.Materials and methods: We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7988be5778fc23d30aa894df5c007c73
https://pubmed.ncbi.nlm.nih.gov/27258624

Simulation of Neutron Interactions at the Single-Cell Level

Autor: Andrei Tchirkov, Veronique Bodez, Maryse Rapp, Jack Arnold, Marie-Laure Nénot, Claude Dionet, Pierre Verrelle, Sylvain Crespin, Jean-Pierre Alard

Publikováno v: Radiation Research
Radiation Research, Radiation Research Society, 2002, 158, pp.650-656
Radiation Research, 2002, 158, pp.650-656

We recently reported that the exposure of cancer cells to 14 MeV neutrons at a very low dose rate (0.8 mGy min(-1)) produced a marked increase in cell killing at 5 cGy, followed by a plateau in survival and chromosomal damage. Simulation of the energ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd30baf62d5dbb3a557fcda4a0fa618
https://doi.org/10.1667/0033-7587(2002)158[0650:soniat]2.0.co

The Hematopoietic Stem Cell Transplantation in Hodgkin's Disease: Questions and Controversies

Autor: R. Plagne, Philippe Chollet, Claude Dionet, Ernest Belembaogo, Françoise Tavernier, Jacques Tortochaux, Hervé Curé, Michel Legros, Philippe Travade, J. Fleury, Fabrice Kwiatkowski, Paule Condat

Publikováno v: Leukemia & Lymphoma. 15:419-432

Most patients with Hodgkin's disease (HD) are cured with chemotherapy and/or radiotherapy. However, half of those with advanced stage disease (IIIB, IV) do not respond adequately to treatment or relapse. Salvage therapy used in such cases gives from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6548651b3ebc16151545a6d089b477b5
https://doi.org/10.3109/10428199409049745

Simulation code for the interaction of 14 MeV neutrons on cells

Autor: Veronique Bodez, M. L. Nénot, Maryse Rapp, Andrei Tchirkov, H. Meunier, J. P. Alard, Jack Arnold, Pierre Verrelle, Claude Dionet

Publikováno v: Radiation Protection Dosimetry
Radiation Protection Dosimetry, Oxford University Press (OUP), 2002, 99, pp.47-48
Radiation Protection Dosimetry, 2002, 99, pp.47-48

The structure of the survival curve of melanoma cells irradiated by 14 MeV neutrons displays unusual features at very low dose rate where a marked increase in cell killings at 0.05 Gy is followed by a plateau for survival from 0.1 to 0.32 Gy. In para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7faa462267aa7f103f8bed19f51a74ef
http://hal.in2p3.fr/in2p3-00012049

Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma

Autor: R. Plagne, Jacques Chassagne, Claude Dionet, Pierre Verrelle, Meissonnier Frédéric, Fabrice Kwiatkowski, Yvette Fonck, V. Feillel

Publikováno v: Journal of the National Cancer Institute. 83(2)

In 20 women with breast carcinoma, 17 of whom had locally advanced cancer and 3 of whom had confirmed metastases, the expression of P-glycoprotein was evaluated before the start of a chemotherapy regimen that included multidrug resistance-related dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a486a783c66b5d99c956f06706b4401
https://pubmed.ncbi.nlm.nih.gov/1671104