Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Claude Delatour"'
Autor:
Benoit Cox, Patrick Barton, Reiner Class, Hannah Coxhead, Claude Delatour, Eric Gillent, Jamie Henshall, Emre M. Isin, Lloyd King, Jean-Pierre Valentin
Publikováno v:
Biomaterials and Biosystems, Vol 7, Iss , Pp 100054- (2022)
Human 3D liver microtissues/spheroids are powerful in vitro models to study drug-induced liver injury (DILI) but the small number of cells per spheroid limits the models’ usefulness to study drug metabolism. In this work, we scale up the number of
Externí odkaz:
https://doaj.org/article/4f84f1c7e9f24453a86a0742477c1d28
Autor:
Johan Nicolaï, Claude Delatour, Pierre Bonnaillie, Claire Beckers, Kenneth Saunders, Eric Gillent, Marie-Lynn Cuypers, Anna-Lena Ungell, Hugues Chanteux, Sylvie Dell'Aiera
Publikováno v:
Drug Metabolism and Disposition. 48:1121-1128
Early assessment of metabolism pathways of new chemical entities guides the understanding of drug-drug interactions. Selective enzyme inhibitors are indispensable in CYP reaction phenotyping. The most commonly applied CYP2C19 inhibitor, omeprazole, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb66d0a34defd0d518729a10d97a0fab
https://doi.org/10.1124/dmd.120.000089
https://doi.org/10.1124/dmd.120.000089
Autor:
Sylvie Dell'Aiera, Eric Gillent, Hugues Chanteux, Maria Rosa, Claude Delatour, Johan Nicolaï, Anna-Lena Ungell
Publikováno v:
Drug Metabolism and Disposition. 48:778-787
Early determination of CYP3A4/5 contribution to the clearance of new chemical entities is critical to inform on the risk of drug-drug interactions with CYP3A inhibitors and inducers. Several in vitro approaches (recombinant P450 enzymes, correlation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c9d2ea0b2908f74dd8b0dbe8f20a58
https://doi.org/10.1124/dmd.120.000017
https://doi.org/10.1124/dmd.120.000017
Autor:
Philip Timmerman, Martha Green, Stephen White, Claude Delatour, Stefan Blech, John Smeraglia, Stuart McDougall, Geert Mannens, Graeme Young, Stephen Alaric Williams
Publikováno v:
Bioanalysis. 8:1297-1305
Metabolite quantification and profiling continues to grow in importance in today's drug development. The guidance provided by the 2008 FDA Metabolites in Safety Testing Guidance and the subsequent ICH M3(R2) Guidance (2009) has led to a more streamli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2395806e94ec947369a8028d2cd8ea5
https://doi.org/10.4155/bio-2016-0103
https://doi.org/10.4155/bio-2016-0103
Autor:
Franck A. Atienzar, Helga Gerets, Eric Novik, Claude Delatour, Alvaro Cardenas, Martin L. Yarmush, Amit Parekh, James S. MacDonald, Stephane Dhalluin
Publikováno v:
Toxicology and Applied Pharmacology. 275:44-61
Drug Induced Liver Injury (DILI) is a major cause of attrition during early and late stage drug development. Consequently, there is a need to develop better in vitro primary hepatocyte models from different species for predicting hepatotoxicity in bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd1033c7f82b940dca2fd902fa95a1e
https://doi.org/10.1016/j.taap.2013.11.022
https://doi.org/10.1016/j.taap.2013.11.022
Autor:
Claude Delatour, Jose Castro-Perez, Françoise Brunelle, Xavier Labrique, Ilse Hoes, Laurent Leclercq
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:1611-1618
Metabolism data provided with reduced cycle time has become of increasing importance for the early evaluation of DMPK properties of drugs in discovery. In this regard, quadrupole time-of-flight hybrid mass spectrometers (Q-TOF) can provide very relia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eaac3e234576f38e884e8da2912dc1
https://doi.org/10.1002/rcm.1964
https://doi.org/10.1002/rcm.1964
Autor:
Chandra Prakash, Steven Smith, Jean-Marie Nicolas, Hugues Chanteux, Claude Delatour, Maria Rosa
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(1)
We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its transesterification in the presence of ethanol with special emphasis on the risks of drug-drug interaction. The hydrolysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fc9cda879e3b1237ed01524ca04701
https://pubmed.ncbi.nlm.nih.gov/24179032
https://pubmed.ncbi.nlm.nih.gov/24179032
Autor:
Claude Delatour, Jean-Pierre Van Hoeck, Anne M. Mockel, Hugo Gorissen, Guido H. Journée, Valéry R. Libert
Publikováno v:
Chirality. 4:286-294
Both (R)- and (S)-4-hydroxypentylaminoacetamide have been synthesized by reductive amination of glycinamide on the γ-valerolactols corresponding to (R)- and (S)-γ-valerolactone, respectively. These enantiomeric lactones were readily obtained in hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee154e4a6af8634cb56efbac7546b373
https://doi.org/10.1002/chir.530040505
https://doi.org/10.1002/chir.530040505
Autor:
Laurent Leclercq, Claude Delatour
Publikováno v:
Rapid communications in mass spectrometry : RCM. 19(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8869d53f8bcfefbc842d0f4c84cbd66
https://pubmed.ncbi.nlm.nih.gov/15852452
https://pubmed.ncbi.nlm.nih.gov/15852452
Publikováno v:
Analytical chemistry. 75(4)
Quantitative bioanalysis by direct nanoelectrospray infusion coupled to tandem mass spectrometry has been achieved using an automated liquid sampler integrated with an array of microfabricated electrospray nozzles allowing rapid, serial sample introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daae20de5c6e3714eb280e46125cefd
https://pubmed.ncbi.nlm.nih.gov/12622370
https://pubmed.ncbi.nlm.nih.gov/12622370