Over-expression of erbB-2/neu is paralleled by inhibition of mouse-mammary-epithelial-cell differentiation and developmental apoptosis

Autor: Andreas Marti, Claude D. Gimmi, Hedvika Lazar, Anna Baltzer, Rolf Jaggi

Publikováno v: International Journal of Cancer. 85:578-583

The erbB-2/neu oncogene is frequently over-expressed in many different tumors in humans, including those of breast and ovary. The oncogene encodes a receptor tyrosine kinase closely related to the epidermal-growth-factor receptor. We studied effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2b996b9c801435b61d3906957fe607
https://doi.org/10.1002/(sici)1097-0215(20000215)85:4<578::aid-ijc21>3.0.co

Breast cancer–associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

Autor: Gordon J. Freeman, Michiaki Watanabe, Suun Young Lee Park, Brigitte A. Mainprice, Claude D. Gimmi, Jianlin Gong, Vassiliki A. Boussiotis, Lee M. Nadler, John G. Gribben, Daniel F. Hayes, Briggs W. Morrison, Donald Kufe

Publikováno v: Nature Medicine. 2:1367-1370

Given the plethora of well–documented breast carcinoma–associated antigens in humans including MAGE–1, –2 and –3, mutated p53, p21ras, HER–2/neu and DF3/MUC–1, coupled with evidence that humoral and cytotoxic T–cell responses against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6660b41fabea9c12d3c56e7cd9bf21dc
https://doi.org/10.1038/nm1296-1367

Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma

Autor: Arnold S. Freedman, K Pesek, S D Woo, Claude D. Gimmi, Neil L. Spector, F Coral, Donna Neuberg, Laura Saporito, J. G. Gribben, Michael Barber

Publikováno v: Blood. 81:3449-3457

Although molecular biologic techniques can now detect minimal numbers of residual cancer cells in patients in complete clinical remission, the clinical significance of minimal residual disease has never been conclusively established. If the detection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fd928a8c89de8ee5b64f09210aa2608
https://doi.org/10.1182/blood.v81.12.3449.3449

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2

Autor: Arnold S. Freedman, Chikao Morimoto, John G. Gribben, Lee M. Nadler, Claude D. Gimmi, K Sugita, Gordon J. Freeman

Publikováno v: Proceedings of the National Academy of Sciences. 88:6575-6579

Occupancy of the T-cell receptor complex does not appear to be a sufficient stimulus to induce a T-cell-mediated immune response. Increasing evidence suggests that cognate cell-cell interaction between an activated T cell and an antigen-presenting ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0171c600bc187f2a34aac84a64306af8
https://doi.org/10.1073/pnas.88.15.6575

Virosomes as new carrier system for cancer vaccines

Autor: Claude D. Gimmi, Antoinette Wetterwald, Ruth Schwaninger, Ernst R. Waelti, Paul Zajac, Dominique Mueller

Publikováno v: Schwaninger, Ruth; Wälti, Ernst; Zajac, Paul; Wetterwald, Antoinette; Müller, Dominique-Elisabeth; Gimmi, Claude D. (2004). Virosomes as new carrier system for cancer vaccines. Cancer immunology, immunotherapy, 53(11), pp. 1005-1017. Springer-Verlag 10.1007/s00262-004-0545-5

HER-2/neu, a tumor-associated antigen (TAAg), plays a critical role in oncogenesis of various tumor types, and its selective overexpression by malignant tumor cells makes it an ideal target for immunotherapy. A prerequisite for clinical vaccines is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44db1f3f1a544577a57126bea0722dbe
https://boris.unibe.ch/117924/1/262_2004_Article_545.pdf