Evidence of a role for GTP cyclohydrolase-1 in visceral pain

Autor: Qasim Aziz, David C. Bulmer, K. Grey, A. Wheeldon, Charles A. Mein, Claude Botha, Wendy J. Winchester, Kevin Lee, Charles H. Knowles

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 27(5)

Background The enzyme guanosine triphosphate-cyclohydrolase-1 (GCH-1) is a rate limiting step in the de novo synthesis of tetrahydrobiopterin (BH4) a co-factor in monoamine synthesis and nitric oxide production. GCH-1 is strongly implicated in chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7bab9591e55980e225158dd82e3e79
https://pubmed.ncbi.nlm.nih.gov/25783971

Pharmacology of visceral pain: central factors

Autor: Robert P. Willert, Claude Botha, Qasim Aziz

Publikováno v: Digestive diseases (Basel, Switzerland). 27

Clinically, pain can be sub-classified into superficial, neuropathic and deep pain. Deep pain as a result of stimulation to structures such as the viscera is the most poorly understood and notoriously difficult to treat. The dorsal horn of the spinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7909a3fae8b45e5196a96bd8579810f7
https://pubmed.ncbi.nlm.nih.gov/20203495

Tu2122 Healthy Volunteers With the Pain Protective GTP Cyclohydrolase-1 Haplotype Who Sensitise to Oesophageal Acidification Possess Significantly Higher Pain Thresholds

Autor: Claude Botha, L. Ashley Blackshaw, Qasim Aziz, Wendy J. Winchester, Charles H. Knowles, David C. Bulmer

Publikováno v: Gastroenterology. 144:S-935

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6752e63cacdee0a47730b6243a82bea
https://doi.org/10.1016/s0016-5085(13)63477-0

Effect of Autonomic Modulation on Human Esophageal Pain Hypersensitivity

Autor: Charles H. Knowles, Qasim Aziz, Claude Botha, Hira Naqvi, Yang C. Chua

Publikováno v: Gastroenterology. 140:S-164

Introduction Patients with Functional Gastrointestinal Disorders (FGID) often display persistent and heightened pain sensitivity to experimental gut stimulation, a phenomenon known as Visceral Pain Hypersensitivity (VPH). Current management of pain i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bb530503c724bd9faaa8df293aa47b6
https://doi.org/10.1016/s0016-5085(11)60664-1

Normal values and reproducibility of the real-time index of vagal tone in healthy humans: a multi-center study.

Autor: Farmer AD; Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (Adam D. Farmer, Steven J. Coen, Michiko Kano, Claude Botha, Qasim Aziz)., Coen SJ; Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (Adam D. Farmer, Steven J. Coen, Michiko Kano, Claude Botha, Qasim Aziz)., Kano M; Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (Adam D. Farmer, Steven J. Coen, Michiko Kano, Claude Botha, Qasim Aziz) ; Behavioural Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (Michiko Kano)., Weltens N; Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Belgium (Nathalie Weltens, Huynh Giao Ly, Lukas Van Oudenhove)., Ly HG; Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Belgium (Nathalie Weltens, Huynh Giao Ly, Lukas Van Oudenhove)., Botha C; Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (Adam D. Farmer, Steven J. Coen, Michiko Kano, Claude Botha, Qasim Aziz)., Paine PA; Salford Royal Foundation NHS Trust, UK (Peter A. Paine) ; Gastrointestinal Sciences, University of Manchester, UK (Peter A. Paine)., Oudenhove LV; Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Belgium (Nathalie Weltens, Huynh Giao Ly, Lukas Van Oudenhove)., Aziz Q; Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (Adam D. Farmer, Steven J. Coen, Michiko Kano, Claude Botha, Qasim Aziz).

Publikováno v: Annals of gastroenterology [Ann Gastroenterol] 2014; Vol. 27 (4), pp. 362-368.