Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways.

Autor: Grégory Jubelin, Frédéric Taieb, David M Duda, Yun Hsu, Ascel Samba-Louaka, Rika Nobe, Marie Penary, Claude Watrin, Jean-Philippe Nougayrède, Brenda A Schulman, C Erec Stebbins, Eric Oswald

Publikováno v: PLoS Pathogens, Vol 6, Iss 9, p e1001128 (2010)

The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates and invertebrates, belong to a family of molecules called cyclomodulins that interfere with the eukaryotic cell cycle. Cif blocks the cell cycle at both the

Externí odkaz: https://doaj.org/article/ffc0c089152b4d21b4a09b0efdf3bbd2

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

Autor: Jean-Philippe Nougayrède, Frédéric Taieb, Eric Oswald, Ascel Samba-Louaka, Claude Watrin

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2009, 77 (12), pp.5471-5477. ⟨10.1128/IAI.00860-09⟩
Infection and Immunity, 2009, 77 (12), p. 5471-5477. ⟨10.1128/IAI.00860-09⟩

The cycle inhibiting factor (Cif) belongs to a family of bacterial toxins, the cyclomodulins, which modulate the host cell cycle. Upon injection into the host cell by the type III secretion system of enteropathogenic Escherichia coli (EPEC), Cif indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69ee3356d51c2dd311750fcdd4155b2
https://doi.org/10.1128/iai.00860-09

Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

Autor: Claude Watrin, Maïwenn Olier, Christel Salvador-Cartier, Delphine Payros, Camille Brehin, Pascale Plaisancié, Michèle Boury, Damien Dubois, Antoine Bedu, Eric Oswald, Jean Fioramonti, Vassilia Theodorou, Jean-Philippe Nougayrède, Erick Denamur, Fabien Garnier, Olivier Clermont, Sandrine Ménard, Gabriel Cuevas-Ramos, Thomas Secher, Ingrid Marcq

Publikováno v: Gut Microbes
Gut Microbes, 2014, 5 (3), pp.313-325. ⟨10.4161/gmic.28932⟩
Gut microbes
Gut microbes, Taylor & Francis, 2014, 5 (3), pp.313-512. ⟨10.4161/gmic.28932⟩
Gut Microbes, 2014, 5 (3), pp.313-25. ⟨10.4161/gmic.28932⟩

International audience; The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d472ff1651c9222645e8c5ce8362c4f
https://hal.archives-ouvertes.fr/hal-01859355

Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways

Autor: Jean-Philippe Nougayrède, C. Erec Stebbins, Ascel Samba-Louaka, Eric Oswald, Brenda A. Schulman, Claude Watrin, David M. Duda, Grégory Jubelin, Yun Hsu, Marie Penary, Rika Nobe, Frédéric Taieb

Publikováno v: PLoS Pathogens, Vol 6, Iss 9, p e1001128 (2010)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2010, 6 (9), n.p. ⟨10.1371/journal.ppat.1001128⟩
Plos Pathogens 9 (6), n.p.. (2010)
PLoS Pathogens, 2010, 6 (9), pp.e1001128. ⟨10.1371/journal.ppat.1001128⟩
PLoS Pathogens, Public Library of Science, 2010, 6 (9), pp.e1001128. ⟨10.1371/journal.ppat.1001128⟩

The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates and invertebrates, belong to a family of molecules called cyclomodulins that interfere with the eukaryotic cell cycle. Cif blocks the cell cycle at both the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d84751d880fe3908c58b1d1848565b5
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941356/pdf/?tool=EBI

Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21 waf1 and p27 kip1

Autor: Claude Watrin, Jean-Philippe Nougayrède, Ascel Samba-Louaka, Eric Oswald, Grégory Jubelin, Frédéric Taieb

Publikováno v: Cellular Microbiology
Cellular Microbiology, 2008, 10 (12), pp.2496-2508. ⟨10.1111/j.1462-5822.2008.01224.x⟩
Cellular Microbiology, Wiley, 2008, 10 (12), pp.2496-2508. ⟨10.1111/j.1462-5822.2008.01224.x⟩

Summary The cycle inhibiting factor (Cif) is a cyclomodulin produced by enteropathogenic and enterohemorrhagic Escherichia coli. Upon injection into the host cell by the bacterial type III secretion system, Cif inhibits the G2/M transition via sustai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc0836e068a7ce789c314a428f3139f
https://doi.org/10.1111/j.1462-5822.2008.01224.x