Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA

Autor: François-Xavier Campbell-Valois, Martin Sachse, Philippe J. Sansonetti, Claude Parsot

Publikováno v: mBio, Vol 6, Iss 3 (2015)

ABSTRACT The enteropathogenic bacterium Shigella flexneri uses a type 3 secretion apparatus (T3SA) to transfer proteins dubbed translocators and effectors inside host cells, inducing bacterial uptake and subsequent lysis of the entry vacuole. Once in

Externí odkaz: https://doaj.org/article/e959c8a360154136b755b7e35c93173b

Characterization of the promoter, MxiE box and 5' UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri.

Autor: Clotilde Bongrand, Philippe J Sansonetti, Claude Parsot

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32862 (2012)

Activation of the type III secretion apparatus (T3SA) of Shigella flexneri, upon contact of the bacteria with host cells, and its deregulation, as in ipaB mutants, specifically increases transcription of a set of effector-encoding genes controlled by

Externí odkaz: https://doaj.org/article/fb8cfcc7a36b457a9fcaa99dde5d66aa

Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes

Autor: Bruno Baron, Philippe J. Sansonetti, Gyanendra P. Dubey, Mariano Dellarole, Armelle Phalipon, Fatoumata Samassa, Claude Parsot, Katja Brunner, Laurie Pinaud, Ilia Belotserkovsky, Alexander Rouvinski

Publikováno v: mBio, Vol 9, Iss 1 (2018)
mBio
mBio, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, American Society for Microbiology, 2018, 9 (1), pp.e02309-17. ⟨10.1128/mBio.02309-17⟩
mBio, Vol 9, Iss 1, p e02309-17 (2018)

Direct interactions between bacterial and host glycans have been recently reported to be involved in the binding of pathogenic bacteria to host cells. In the case of Shigella, the Gram-negative enteroinvasive bacterium responsible for acute rectocoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e80bd52f8998022a04fac90d09a330
https://journals.asm.org/doi/10.1128/mBio.02309-17

The 33 carboxyl-terminal residues of Spa40 orchestrate the multi-step assembly process of the type III secretion needle complex in Shigella flexneri

Autor: Claude Parsot, Anne-Laure Page, Egbert J. Boekema, Nouredine Jouihri, Musa Sani, Latefa Biskri, Anne Botteaux, Abdelmounaaim Allaoui, Christian Aimé Kayath

Publikováno v: Microbiology-Sgm, 156(9), 2807-2817. MAIK NAUKA/INTERPERIODICA/SPRINGER

The type III secretion apparatus (T3SA) is a central virulence factor of many Gram-negative bacteria. Its overall morphology consists of a cytoplasmic region, inner- and outer-membrane sections and an extracellular needle. InShigella, the length of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcf47fb0fe2512ddc358f3e6c5ae72e
https://doi.org/10.1099/mic.0.039651-0

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

Autor: Robert Lam, John R. Rohde, Claude Parsot, Rosa DiLeo, Philippe J. Sansonetti, Tatiana Skarina, Olga Kagan, Alex U. Singer, Mike Tyers, Marianne E. Cuff, Alexei Savchenko, Nickolay Y. Chirgadze, Andrzej Joachimiak

Publikováno v: Nature Structural & Molecular Biology. 15:1293-1301

IpaH proteins are E3 ubiquitin ligases delivered by the type III secretion apparatus into host cells upon infection of humans by the Gram-negative pathogen Shigella flexneri. These proteins comprise a variable leucine-rich repeat-containing N-termina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f55c38b4ee35b9e6290c83af7fc52f0
https://doi.org/10.1038/nsmb.1511