Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Claude, Oeuvray"'
Autor:
Mohamed Maiga, Laurent Dembele, Perrine Courlet, Akash Khandelwal, Antoine Dara, Fanta Sogore, Ousmaila Diakité, Fatoumata O. Maiga, François Dao, Sekou Sissoko, Yacouba Barre, Siaka Goita, Mahamadou Diakite, Seidina A. S. Diakite, Abdoulaye A. Djimde, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta-Gatsi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The selection and combination of dose regimens for antimalarials involve complex considerations including pharmacokinetic and pharmacodynamic interactions. In this study, we use immediate ex vivo P. falciparum field isolates to evaluate the
Externí odkaz:
https://doaj.org/article/11725860ac3a4f6099cdcb6b162815eb
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant Plasmodium falciparum parasites. Through in vitro studies of laboratory st
Externí odkaz:
https://doaj.org/article/fc7d61999951431e86b5f6942e16ac55
Autor:
Xiaoyan Yin, Ying Li, Wilhelmina Bagchus, Özkan Yalkinoglu, Deon Bezuidenhout, Aliona Tappert, James McCarthy, Louise Marquart, Claude Oeuvray
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background Evaluation of parasite clearance patterns in experimental human infection trials helps increase understanding of drug action. In a previously reported phase Ib trial of a new investigational anti-malarial drug M5717, parasite clea
Externí odkaz:
https://doaj.org/article/f06f350695e94c21af64078bdc6defd9
Autor:
Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, James McCarthy, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite cleara
Externí odkaz:
https://doaj.org/article/c2406534d5854e6ab1c7c2aaa0f7936b
Autor:
Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibitor
Externí odkaz:
https://doaj.org/article/1a184acca8e44dcf9fd53edb5f8e0845
Autor:
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A. Djimdé, Marcus C. S. Lee, Laurent Dembélé, David A. Fidock, David S. Khoury, Thomas Spangenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b0c7124584a34f698dd6a12c343873cc
Autor:
Workineh Shibeshi, Wilhelmina Bagchus, Özkan Yalkinoglu, Aliona Tappert, Ephrem Engidawork, Claude Oeuvray
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background The development of novel malaria vaccines and antimalarial drugs is limited partly by emerging challenges to conduct field trials in malaria endemic areas, including unknown effects of existing immunity and a reported fall in mala
Externí odkaz:
https://doaj.org/article/62bb7a733c2747f7a2c07f158e7cf59c
Autor:
Isaac K. Quaye, Larysa Aleksenko, Giacomo M. Paganotti, Elias Peloewetse, Daniel H. Haiyambo, Davies Ntebela, Claude Oeuvray, Beatrice Greco, the PAVON Consortium
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 8, Iss 8, p 392 (2023)
The global malaria community has picked up the theme of malaria elimination in more than 90% of the world’s population in the next decade. Recent reports of Plasmodium vivax (P. vivax) in sub-Saharan Africa, including in Duffy-negative individuals,
Externí odkaz:
https://doaj.org/article/74aa6e10c72944db8bed46ddacb1a2a5
Autor:
Mark S Pearson, PhD, Bemnet A Tedla, PhD, Gebeyaw G Mekonnen, PhD, Carla Proietti, PhD, Luke Becker, BSc, Rie Nakajima, MSc, Al Jasinskas, PhD, Denise L Doolan, PhD, Abena S Amoah, PhD, Stefanie Knopp, PhD, David Rollinson, PhD, Said M Ali, MSc, Fatma Kabole, MD, Cornelis H Hokke, PhD, Akim A Adegnika, MD, Matt A Field, PhD, Govert van Dam, PhD, Paul L A M Corstjens, PhD, Takafira Mduluza, PhD, Francisca Mutapi, PhD, Claude Oeuvray, PhD, Beatrice Greco, PhD, Sujittra Chaiyadet, PhD, Thewarach Laha, PhD, Pengfei Cai, PhD, Donald P McManus, PhD, Maria Elena Bottazzi, PhD, Philip L Felgner, PhD, Javier Sotillo, PhD, Alex Loukas, PhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 11, Pp e617-e626 (2021)
Summary: Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to
Externí odkaz:
https://doaj.org/article/e9c0510583ca4bf58360b82613221a36
Autor:
Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Philip L. Felgner, Alex Loukas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people. The anthelmintic drug, praziquantel, is the mainstay treatment option, although its molecul
Externí odkaz:
https://doaj.org/article/58e793b9da6441c9a8a7d8fd0a89b538