Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Claude, Libert"'
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2678-2698 (2024)
Abstract Sepsis is a heterogeneous syndrome resulting from a dysregulated host response to infection. It is considered as a global major health priority. Sepsis is characterized by significant metabolic perturbations, leading to increased circulating
Externí odkaz:
https://doaj.org/article/bd02f6a134e4417e99822c15ff14f5ae
Autor:
Céline Van Dender, Steven Timmermans, Ville Paakinaho, Tineke Vanderhaeghen, Jolien Vandewalle, Maarten Claes, Bruno Garcia, Bart Roman, Jan De Waele, Siska Croubels, Karolien De Bosscher, Philip Meuleman, Antoine Herpain, Jorma J Palvimo, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2485-2515 (2024)
Abstract In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free f
Externí odkaz:
https://doaj.org/article/a06f4ebf50eb4404b264053ba4838ecb
Autor:
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Nicholas Shukeir, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that hete
Externí odkaz:
https://doaj.org/article/8624fe27fea0477cbeee8d7082173fcb
Autor:
Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription fa
Externí odkaz:
https://doaj.org/article/1e23832839bc4f67a6376a644117993b
Autor:
Thierry M. Legroux, Hanna S. Schymik, Gilles Gasparoni, Saeed Mohammadi, Jörn Walter, Claude Libert, Britta Diesel, Jessica Hoppstädter, Alexandra K. Kiemer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Glucocorticoids, which have long served as fundamental therapeutics for diverse inflammatory conditions, are still widely used, despite associated side effects limiting their long-term use. Among their key mediators is glucocorticoid-induced leucine
Externí odkaz:
https://doaj.org/article/aa245194554e4575ad448d13c8c14fd7
Autor:
Steven Timmermans, Charlotte Wallaeys, Natalia Garcia-Gonzalez, Lotte Pollaris, Yvan Saeys, Claude Libert
Publikováno v:
Cells, Vol 13, Iss 17, p 1435 (2024)
The small intestinal crypts harbor secretory Paneth cells (PCs) which express bactericidal peptides that are crucial for maintaining intestinal homeostasis. Considering the diverse environmental conditions throughout the course of the small intestine
Externí odkaz:
https://doaj.org/article/5c669b8bb3464122a428313edbc52580
Autor:
Claudia Theys, Tineke Vanderhaeghen, Evelien Van Dijck, Cedric Peleman, Anne Scheepers, Joe Ibrahim, Ligia Mateiu, Steven Timmermans, Tom Vanden Berghe, Sven M. Francque, Wim Van Hul, Claude Libert, Wim Vanden Berghe
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2024)
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is a growing epidemic with an estimated prevalence of 20%–30% in Europe and the most common cause of chronic liver disease worldwide. The onset and progression of MASLD are orchestrat
Externí odkaz:
https://doaj.org/article/949581703c6a48e18ffca39d01ec79c1
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-26 (2022)
Abstract Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by pro
Externí odkaz:
https://doaj.org/article/4841a5af76f84da8a2601b3f98ea63b4
Autor:
Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic pero
Externí odkaz:
https://doaj.org/article/d4cf3b606e8c4e34ae118f7e43e47016
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814