Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Claude, Dagenais"'
Autor:
Richard R. Desrosiers, Delara Karkan, Tran Nguyen, Julie Lanthier, Yanick Bertrand, Wilfred A. Jefferies, Michel Demeule, Sam Tsai, Roméo Cecchelli, Claude Dagenais, Richard Béliveau, Julie Poirier, Laurence Fenart, Reinhard Gabathuler, Malcolm L. Kennard, Julie Jodoin
Publikováno v:
Journal of Neurochemistry. 83:924-933
The blood-brain barrier (BBB) performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins as well as pharmacological agents to cerebral tissues. We demonstrate here that recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b811d53514191597be9e934b79bb17
https://doi.org/10.1046/j.1471-4159.2002.01201.x
https://doi.org/10.1046/j.1471-4159.2002.01201.x
Publikováno v:
Neuroscience Letters. 301:155-158
P-glycoprotein (P-gp) and organic anion transporting polypeptides (Oatp) are expressed at the blood–brain barrier (BBB). There is little functional evidence for Oatp-mediated transport at the BBB. The peptidic delta opioid-receptor agonist [D-penic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d6b19dad82d7f8209c8aa4209bc118
https://doi.org/10.1016/s0304-3940(01)01640-8
https://doi.org/10.1016/s0304-3940(01)01640-8
Autor:
Richard Béliveau, Alain Laplante, Anthony Regina, Berthelet F, Albert Moghrabi, Michel Demeule, Julie Jodoin, Claude Dagenais
Publikováno v:
Cancer and Metastasis Reviews. 20:13-25
Malignant brain tumors and brain metastases present a formidable clinical challenge against which no significant advances have been made over the last decade. Multidrug resistance (MDR) is one of the main factors in the failure of chemotherapy agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3ddf97c77a1152978fddb7703377212
https://doi.org/10.1023/a:1013104423154
https://doi.org/10.1023/a:1013104423154
Publikováno v:
Pharmaceutical Research. 18:957-963
Purpose. This study assessed the influence of mdr1a P-glycoprotein (P-gp) gene disruption, gender and concentration on initial brain uptake clearance (Clup) of morphine, quinidine and verapamil.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc85512f60f8ee949f865f7c7562773a
https://doi.org/10.1023/a:1010984110732
https://doi.org/10.1023/a:1010984110732
Publikováno v:
Pharmaceutical Research. 18:183-190
Purpose. This study was conducted to assess the influence of P-glycoprotein (P-gp) on brain uptake of multidrug resistance sensitive drugs using an in situbrain perfusion technique in P-gp-deficient (mdr1a[−/−]) and wild-type mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d24b486129e801f7e9198a81cdcdbf9
https://doi.org/10.1023/a:1011080418027
https://doi.org/10.1023/a:1011080418027
Autor:
Linda Foster-Brown, Joseph Milano, Anna Zacco, Claude Dagenais, Barry D. Greenberg, Robert Toms Jacobs, Paul J. Ciaccio, Jenny McKay, Francois Pognan, Reto Gadient
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 82(1)
It is anticipated that gamma-secretase inhibitors (gamma-Sec-I) that modulate Notch processing will alter differentiation in tissues whose architecture is governed by Notch signaling. To explore this hypothesis, Han Wistar rats were dosed for up to 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658d511b7b6bb5f369089bd611ae802d
https://pubmed.ncbi.nlm.nih.gov/15319485
https://pubmed.ncbi.nlm.nih.gov/15319485
Publikováno v:
Biochemical pharmacology. 67(2)
The efflux transporter P-glycoprotein (P-gp) is an important component of the blood-brain barrier (BBB) that limits accumulation of many compounds in brain. Some opioids have been shown to interact with P-gp in vitro and in vivo. Genetic or chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f92195bdd28baba7157db8444bd2ebc
https://pubmed.ncbi.nlm.nih.gov/14698039
https://pubmed.ncbi.nlm.nih.gov/14698039
Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier
Autor:
Michel Demeule, Anthony Régina, Julie Jodoin, Alain Laplante, Claude Dagenais, France Berthelet, Albert Moghrabi, Richard Béliveau
Publikováno v:
Vascular pharmacology. 38(6)
1. The blood-brain barrier (BBB) contributes to brain homeostastis and fulfills a protective function by controlling the access of solutes and toxic substances to the central nervous system (CNS). The efflux transporter P-glycoprotein (P-gp) is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e242144e6e0b2152cf2d8cd9570d121
https://pubmed.ncbi.nlm.nih.gov/12529928
https://pubmed.ncbi.nlm.nih.gov/12529928
Autor:
Michel, Demeule, Julie, Poirier, Julie, Jodoin, Yanick, Bertrand, Richard R, Desrosiers, Claude, Dagenais, Tran, Nguyen, Julie, Lanthier, Reinhard, Gabathuler, Malcolm, Kennard, Wilfred A, Jefferies, Delara, Karkan, Sam, Tsai, Laurence, Fenart, Roméo, Cecchelli, Richard, Béliveau
Publikováno v:
Journal of neurochemistry. 83(4)
The blood-brain barrier (BBB) performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins as well as pharmacological agents to cerebral tissues. We demonstrate here that recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::119ebd80fc8d0a951b06a2f22e7c01d7
https://pubmed.ncbi.nlm.nih.gov/12421365
https://pubmed.ncbi.nlm.nih.gov/12421365
Publikováno v:
Journal of pharmaceutical sciences. 91(1)
Many opioids are substrates of the efflux transporter P ‐glycoprotein (P‐gp) in the blood–brain barrier (BBB). In situ brain perfusion in wild‐type and mdr 1a (−/−) P‐gp‐deficient mice was utilized to investigate potential P‐gp‐me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a393ebc4e00c5487bb13dfe77ec29ec1
https://pubmed.ncbi.nlm.nih.gov/11782913
https://pubmed.ncbi.nlm.nih.gov/11782913