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3-Hydroxykynurenine targets kainate receptors to promote defense against infection.

Autor: Parada-Kusz M; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clatworthy AE; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA. clatwort@broadinstitute.org.; Department of Genetics, Harvard Medical School, Boston, MA, USA. clatwort@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. clatwort@broadinstitute.org., Goering ER; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Blackwood SM; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shigeta JY; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mashin E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Salm EJ; Department of Cellular and Molecular Physiology and Neuroscience, Yale School of Medicine, New Haven, CT, USA., Choi C; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Combs S; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee JSW; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rodriguez-Osorio C; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clish C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tomita S; Department of Cellular and Molecular Physiology and Neuroscience, Yale School of Medicine, New Haven, CT, USA., Hung DT; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital (MGH), Boston, MA, USA. hung@molbio.mgh.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. hung@molbio.mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. hung@molbio.mgh.harvard.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2024 Dec; Vol. 20 (12), pp. 1586-1596. Date of Electronic Publication: 2024 Jun 19.

Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis .

Autor: Sturm A; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Sun P; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA., Avila-Pacheco J; Metabolomics Platform, Broad Institute, Cambridge, Massachusetts, USA., Clatworthy AE; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Bloom-Ackermann Z; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Wuo MG; Department of Chemistry, MIT, Cambridge, Massachusetts, USA., Gomez JE; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Jin S; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA., Clish CB; Metabolomics Platform, Broad Institute, Cambridge, Massachusetts, USA., Kiessling LL; Department of Chemistry, MIT, Cambridge, Massachusetts, USA., Hung DT; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: MBio [mBio] 2024 Feb 14; Vol. 15 (2), pp. e0320823. Date of Electronic Publication: 2024 Jan 18.

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.

Autor: Levraud JP; Université Paris-Saclay, CNRS, Institut Pasteur, Université Paris-Cité, Institut des Neurosciences Paris-Saclay, 91400, Saclay, France. jean-pierre.levraud@pasteur.fr., Rawls JF; Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, 213 Research Drive, Durham, NC, 27710, USA. john.rawls@duke.edu., Clatworthy AE; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. clatwort@broadinstitute.org.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA. clatwort@broadinstitute.org.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2022 Jun 28; Vol. 19 (1), pp. 170. Date of Electronic Publication: 2022 Jun 28.