Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Class I Phosphatidylinositol 3-Kinase"'
Autor:
J.Y. Hsu, Na Cui, Susan Dent, Sofia Sousa, Timothy R. Wilson, Véronique Diéras, William Jacot, Ian E. Krop, Frauke Schimmoller, M. De Laurentiis, Nadia Harbeck, Yunjoo Im, Jing He, J. Cortes, Pamela Drullinsky
Publikováno v:
Annals of Oncology. 32:197-207
Background The phase III SANDPIPER study assessed taselisib (GDC-0032), a potent, selective PI3K inhibitor, plus fulvestrant in estrogen receptor-positive, HER2-negative, PIK3CA-mutant locally advanced or metastatic breast cancer. Patients and method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdee42c75cb939356b9f98869998bca
https://doi.org/10.1016/j.annonc.2020.10.596
https://doi.org/10.1016/j.annonc.2020.10.596
Autor:
Angel Guerrero-Zotano, Lewis C. Cantley, Kyungmin Lee, Paula I. Gonzalez-Ericsson, Ganesh V. Raj, Kevin M. Dean, Melinda E. Sanders, Ariella B. Hanker, Alberto Servetto, Thomas Stricker, Reto Fiolka, Chang-Ching Lin, Carlos L. Arteaga, Dhivya R. Sudhan, Valerie M. Jansen, Luigi Formisano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes to endocrine resistance in this amplicon are unclear. Here, we interrogate transcriptome data from primary breast tumors and find that among genes in 17q23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106a0de5bb974ae3023fe077f153aa06
http://link.springer.com/article/10.1038/s41467-020-19291-x
http://link.springer.com/article/10.1038/s41467-020-19291-x
Autor:
Britta Weigelt, Anne Pavlick, C. Kent Osborne, Marilyn M. Li, Kathleen A. Burke, Jorge S. Reis-Filho, Tao Wang, Fresia Pareja, Matthew P. Goetz, Rachel Schiff, Jenny C. Chang, Rita Nanda, Suzanne A. W. Fuqua, Carmine De Angelis, Ian E. Krop, Ingrid A. Mayer, Mothaffar F. Rimawi, Sabrina Herrera, Antonio C. Wolff, Andres Forero, Felipe C Geyer, Alejandro Contreras, Susan G. Hilsenbeck, Carolina Gutierrez
Publikováno v:
Breast Cancer Research and Treatment. 167:731-740
Aberrant activation of the PI3K pathway has been implicated in resistance to HER2-targeted therapy, but results of clinical trials are confounded by the co-administration of chemotherapy. We investigated the effect of perturbations of this pathway in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dbfe4f85e97a7e7e1ced400f550593
https://doi.org/10.1007/s10549-017-4533-9
https://doi.org/10.1007/s10549-017-4533-9
Autor:
Carlos L. Arteaga, Mark Clemons, Soulef Hachemi, Barbara Pistilli, Javier Cortes, José Baselga, Zefei Jiang, Norikazu Masuda, Agnieszka Jagiełło-Gruszfeld, Bharani Dharan, Seock–Ah –A Im, Masato Takahashi, Patrick Urban, Peter Vuylsteke, Ling Ming Tseng, Hiroji Iwata, Mario Campone, Walter Jonat, Yoshinori Ito, Sara A. Hurvitz, Ahmad Awada, Michele De Laurentiis, Cristian Massacesi, Stephen Chia, Emmanuelle di Tomaso
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The Lancet. Oncology, vol 18, iss 7
Consejería de Sanidad de la Comunidad de Madrid
The Lancet. Oncology, vol 18, iss 7
BackgroundPhosphatidylinositol 3-kinase (PI3K) pathway activation is a hallmark of endocrine therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed the efficacy of the pan-PI3K inhibitor buparlisib plus fulvestrant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e398a8fee0a6e9dd1ddee0b7688458f1
https://doi.org/10.1016/s1470-2045(17)30376-5
https://doi.org/10.1016/s1470-2045(17)30376-5
Autor:
Claudia Mescoli, Michele Martino, Fausto Sessa, Massimo Rugge, Ombretta Luinetti, Gabriella Nesi, Vincenzo Canzonieri, Alessandro Vanoli, Luca Reggiani Bonetti, Ada Maria Florena, Giovanni Monteleone, Daniela Furlan, Umberto Volta, Paolo Fociani, Vincenzo Villanacci, Antonino Giulio Giannone, Marco Silano, Antonio Di Sabatino, Antonio Maccioni, Paolo Usai, G. Solina, Vittorio Perfetti, Federica Grillo, Maria Cristina Macciomei, Rachele Manca, Stefano Ferrero, Renato Cannizzaro, Aroldo Rizzo, Livia Biancone, Luca Elli, Claudio Papi, Giacomo Caio, Giovanni Latella, Antonio Calabrò, Roberta Cerutti, Marianna Salemme, Paolo Giuffrida, Gianluca M. Sampietro, Gino Roberto Corazza, Paola Migliora, Donatella Santini, Sandro Ardizzone, Augusto Orlandi, Francesco Tonelli, Antonio Ciardi, Catherine Klersy, Carolina Ciacci, Davide Trapani, Renata D'Incà, Francesco Paolo D'Armiento, Marco Paulli, Marco Astegiano, Roberto Caronna, Roberto Fiocca, Luigi Michele Coppola, Paola Alberizzi, Enrico Solcia, Giuseppe Santeusanio, G. Sandri, Roberta Riboni
Publikováno v:
Journal of Crohn's and Colitis. 11:942-953
Background and aims An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075a61d8e24f495482237cf2948fe2b
https://doi.org/10.1093/ecco-jcc/jjx031
https://doi.org/10.1093/ecco-jcc/jjx031
Autor:
Ma Pelagatti, Silvia Giliani, Francesco Saettini, Daniele Moratto, Raffaele Badolato, Andrea Biondi, D Sala
Publikováno v:
Immunology Letters. 190:279-281
Heterozygous gain of function mutations in the gene encoding p110δ subunit of PI3K have been recently associated with activated PI3K-δ syndrome (APDS), a novel combined immune deficiency characterized by recurrent sinopulmonary infections, lymphope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555bacaf95a9b9963cd3bacc19204d8b
https://doi.org/10.1016/j.imlet.2017.08.021
https://doi.org/10.1016/j.imlet.2017.08.021
Autor:
Chandandeep Nagi, Hariprasad Thangavel, Mario Giuliano, Lacey E. Dobrolecki, Agostina Nardone, Carmine De Angelis, Meghana V. Trivedi, Michael T. Lewis, Rachel Schiff, Jackie L. Stilwell, C. Kent Osborne, Debashish Sahay, Sina Hedayatpour, Raksha Bhat, Eric P. Kaldjian, Mothaffar F. Rimawi, Arturo Ramirez
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Background Breast cancer patient-derived xenograft (BC-PDX) models represent a continuous and reproducible source of circulating tumor cells (CTCs) for studying their role in tumor biology and metastasis. We have previously shown the utility of BC-PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688296ce56fe9a1f54200af1da1bcffe
http://hdl.handle.net/11588/771300
http://hdl.handle.net/11588/771300
Autor:
Claudio Garavaglia, Marco Severgnini, Renato Longhi, Giulia Casorati, Michele C Romano, Norma Ferrero, Elena Orsenigo, Daniele Mennonna, Gina Mazzola, Ludovica Baldari, Elisabetta Zino, Luca Albarello, Cristina Maccalli, Marco Braga, Antonio Amoroso, Alessandro Sette, Roberta Bordoni, Luca Ghirardelli, Giorgio Parmiani, John Sidney, Gianluca De Bellis, Paolo Dellabona, Katharina Fleischhauer, Filippo Capocefalo, Alessandro Gori
Publikováno v:
Gut
Gut 66 (2017): 454–463. doi:10.1136/gutjnl-2015-309453
info:cnr-pdr/source/autori:Mennonna D.; Maccalli C.; Romano M.C.; Garavaglia C.; Capocefalo F.; Bordoni R.; Severgnini M.; De Bellis G.; Sidney J.; Sette A.; Gori A.; Longhi R.; Braga M.; Ghirardelli L.; Baldari L.; Orsenigo E.; Albarello L.; Zino E.; Fleischhauer K.; Mazzola G.; Ferrero N.; Amoroso A.; Casorati G.; Parmiani G.; Dellabona P./titolo:T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes/doi:10.1136%2Fgutjnl-2015-309453/rivista:Gut/anno:2017/pagina_da:454/pagina_a:463/intervallo_pagine:454–463/volume:66
Gut 66 (2017): 454–463. doi:10.1136/gutjnl-2015-309453
info:cnr-pdr/source/autori:Mennonna D.; Maccalli C.; Romano M.C.; Garavaglia C.; Capocefalo F.; Bordoni R.; Severgnini M.; De Bellis G.; Sidney J.; Sette A.; Gori A.; Longhi R.; Braga M.; Ghirardelli L.; Baldari L.; Orsenigo E.; Albarello L.; Zino E.; Fleischhauer K.; Mazzola G.; Ferrero N.; Amoroso A.; Casorati G.; Parmiani G.; Dellabona P./titolo:T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes/doi:10.1136%2Fgutjnl-2015-309453/rivista:Gut/anno:2017/pagina_da:454/pagina_a:463/intervallo_pagine:454–463/volume:66
ObjectivePatient-specific (unique) tumour antigens, encoded by somatically mutated cancer genes, generate neoepitopes that are implicated in the induction of tumour-controlling T cell responses. Recent advancements in massive DNA sequencing combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2fea23e1c642cbcc94923ba370d490
http://europepmc.org/articles/PMC5534766
http://europepmc.org/articles/PMC5534766
Autor:
Felipe C Geyer, Emad A. Rakha, Fresia Pareja, Rodrigo Gularte-Mérida, Gábor Cserni, Britta Weigelt, Edi Brogi, Barbara Alemar, Jorge S. Reis-Filho, Dilip Giri, John R. Lozada, Maria Pia Foschini, Patricia Querzoli, Arnaud Da Cruz Paula, Thais Basili
Aims Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histological type of breast cancer that resembles morphologically t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3457d7845580d6aadb8a5559bd10498c
http://hdl.handle.net/11392/2401346
http://hdl.handle.net/11392/2401346
Autor:
Rita Fragoso, Franco Locatelli, Alessandra Cappellini, Francesca Buontempo, Annalisa Lonetti, Mariana L. Oliveira, João Pedro Taborda Barata, Luca M. Neri, Alberto M. Martelli, Andrea Pession, Alice Bertaina, Lucia Manzoli, Cecilia Evangelisti, Francesca Chiarini, Ester Orsini, Camilla Evangelisti, Carolina Simioni
Publikováno v:
Journal of Cellular Physiology
Despite remarkable progress in polychemotherapy protocols, pediatric B-cell acute lymphoblastic leukemia (B-ALL) remains fatal in around 20% of cases. Hence, novel targeted therapies are needed for patients with poor prognosis. Glucocorticoids (GCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dea69da09fbb0d3285c888f6f8141df
https://pubmed.ncbi.nlm.nih.gov/28777460
https://pubmed.ncbi.nlm.nih.gov/28777460