Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Autor: Dominic G. Whittaker, Haibo Ni, Alan P. Benson, Jules C. Hancox, Henggui Zhang

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatm

Externí odkaz: https://doaj.org/article/eefabde0f55c4c9a993540dea2eff325

Metastatic Risk Factors Associated with Class 1A Uveal Melanoma Patients

Autor: Yong Qin, Maura S. Glover, Elizabeth Urias, Stephen K. Gruschkus, Michelle A. Williams, Sapna Pradyuman Patel, Alexej Ballhausen, Dan S. Gombos

Publikováno v: Cancers
Volume 13
Issue 13
Cancers, Vol 13, Iss 3292, p 3292 (2021)

In uveal melanoma (UM), gene expression profiling (GEP) is commonly used to classify metastatic risk into three groups (Class 1A, 1B, and 2). Class 1A patients have a lower metastatic risk of 2% at 5 years compared to other groups. We aimed to descri

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Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Autor: Whittaker, DG, Ni, H, Benson, AP, Hancox, JC, Zhang, H

Publikováno v: Whittaker, D G, Ni, H, Benson, A P, Hancox, J C & Zhang, H 2017, ' Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles ', Frontiers in Physiology, vol. 8, 759 . https://doi.org/10.3389/fphys.2017.00759
Whittaker, D G, Ni, H, Benson, A P, Hancox, J C & Zhang, H 2017, ' Computational analysis of the mode of action of disopyramide and quinidine on heRG-linked short QT syndrome in human ventricles ', Frontiers in Physiology, vol. 8, no. OCT, 759 . https://doi.org/10.3389/fphys.2017.00759

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9769ac342524ab2b12be549d6055c8b1
https://research-information.bris.ac.uk/en/publications/ab57d7b8-26e4-44bc-b504-7bfbe3ef13b2

Estudo do mecanismo e inibição da enzima diidroorotato desidrogenase de Leishmania major

Autor: Renata Almeida Garcia Reis

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Diidroorotato desidrogenases (DHODHs) catalisam a quarta e única reação de oxidorredução na via de síntese de novo de nucleotídeos de pirimidina, que envolve a oxidação do diidroorotato (DHO) a orotato (ORO) em um mecanismo dependente do cof

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/60/60136/tde-06102016-111707/