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of 97
pro vyhledávání: '"Clarke, Earl"'
Akademický článek
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Autor:
Goncalves, Maria B., Yue Wu, Clarke, Earl, Grist, John, Moehlin, Julien, Mendoza-Parra, Marco Antonio, Hobbs, Carl, Kalindjian, Barret, Fok, Henry, Mander, Adrian P., Hassanin, Hana, Bendel, Daryl, Täubel, Jörg, Mant, Tim, Carlstedt, Thomas, Jack, Julian, Corcoran, Jonathan P. T.
Publikováno v:
Frontiers in Molecular Neuroscience; 2024, p1-18, 18p
Autor:
Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Publikováno v:
In iScience 25 October 2019 20:554-566
Autor:
Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 February 2018 26(4):798-814
Akademický článek
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Autor:
Goncalves, Maria B., Mant, Tim, Täubel, Jörg, Clarke, Earl, Hassanin, Hana, Bendel, Daryl, Fok, Henry, Posner, John, Holmes, Jane, Mander, Adrian P., Corcoran, Jonathan P. T.
Publikováno v:
British Journal of Clinical Pharmacology; Dec2023, Vol. 89 Issue 12, p3573-3583, 11p
Autor:
Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher, Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Goncalves, M B, Clarke, E, Jarvis, C, Kalindjian, S B, Pitcher, T, Grist, J, Hobbs, C, Carlstedt, T, Jack, J, Brown, J T, Mills, M, Mumford, P, Borthwick, A D & Corcoran, J P T 2019, ' Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury ', Bioorganic & medicinal chemistry letters, vol. 29, no. 8, pp. 995-1000 . https://doi.org/10.1016/j.bmcl.2019.02.011
Goncalves, M B, Clarke, E, Jarvis, C, Kalindjian, S B, Pitcher, T, Grist, J, Hobbs, C, Carlstedt, T, Jack, J, Brown, J T, Mills, M, Mumford, P, Borthwick, A D & Corcoran, J P T 2019, ' Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury ', Bioorganic & medicinal chemistry letters, vol. 29, no. 8, pp. 995-1000 . https://doi.org/10.1016/j.bmcl.2019.02.011
Graphical abstract
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::212eb1e845c6f4ef01aa7ee308576bc8
http://europepmc.org/articles/PMC6419571
http://europepmc.org/articles/PMC6419571
Autor:
Goncalves, Maria B., Wu, Yue, Clarke, Earl, Grist, John, Hobbs, Carl, Trigo, Diogo, Jack, Julian, Corcoran, Jonathan P.T.
Publikováno v:
The Journal of Neuroscience
In the CNS, oligodendrocytes are responsible for myelin formation and maintenance. Following spinal cord injury, oligodendrocyte loss and an inhibitory milieu compromise remyelination and recovery. Here, we explored the role of retinoic acid receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ebddd19beddd5a33263e55b41579ec5
http://europepmc.org/articles/PMC6468108
http://europepmc.org/articles/PMC6468108
Autor:
Goncalves, Maria B., Wu, Yue, Trigo, Diogo, Clarke, Earl, Malmqvist, Tony, Grist, John, Hobbs, Carl, Carlstedt, Thomas P., Corcoran, Jonathan P.T.
Publikováno v:
Neurobiology of Disease, Vol 111, Iss, Pp 70-79 (2018)
Neurobiology of Disease
Neurobiology of Disease
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02e3619770b89d6ea61c7e6b74d71f73
http://www.sciencedirect.com/science/article/pii/S0969996117302954
http://www.sciencedirect.com/science/article/pii/S0969996117302954
Autor:
Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publikováno v:
Clarke, E, Jarvis, C I, Goncalves, M B, Kalindjian, S B, Adams, D R, Brown, J T, Shiers, J J, Taddei, D M A, Ravier, E, Barlow, S, Miller, I, Smith, V, Borthwick, A D & Corcoran, J P T 2017, ' Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2017.12.015
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5, which has good selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2761::4f01b85a6ae25d2064dcf50e0fa4e191
https://kclpure.kcl.ac.uk/ws/files/83192231/Design_and_synthesis_of_CLARKE_Publishedonline9December2017_GREEN_AAM_CC_BY_NC_ND_.pdf
https://kclpure.kcl.ac.uk/ws/files/83192231/Design_and_synthesis_of_CLARKE_Publishedonline9December2017_GREEN_AAM_CC_BY_NC_ND_.pdf
