Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials

Autor: Cassetti, Lidia, David, Daniel, Figueras, Laura, Losso, Marcelo, Lopardo, Gustavo, Lupo, Sergio, Porteiro, Norma, Sánchez, Marisa, Bloch, Mark, Cooper, David, Finlayson, Robert, Kelleher, Anthony, Koh, Kenneth, Lewis, David, McMahon, James, Moore, Richard, Roth, Norman, Shields, Matthew, De Wit, Stephane, Florence, Eric, Goffard, Jean-Christophe, Demeester, Remy, Lacor, Patrick, Vandercam, Bernard, Vandekerckhove, Linos, Angel, Jonathan, Baril, Jean-Guy, Conway, Brian, De Pokomandy, Alexandra, Szabo, Jason, Walmsley, Sharon, Bouchaud, Olivier, Chidiac, Christian, Delobel, Pierre, Goujard, Cecile, Katlama, Christine, Molina, Jean-Michel, Pialoux, Gilles, Philibert, Patrick, Bogner, Johannes, Esser, Stefan, Krznaric, Ivanka, Lehmann, Clara, Spinner, Christoph, Stellbrink, Hans-Jurgen, Stephan, Christoph, Stoehr, Albrecht, Barchi, Enrico, Caramello, Pietro, Castelli, Francesco, Cattelan, Anna Maria, D'Arminio Monforte, Antonella, Di Biagio, Antonio, Di Perri, Giovanni, Gori, Andrea, Maggiolo, Franco, Menzaghi, Barbara, Migliorino, Guglielmo, Mussini, Cristina, Penco, Giovanni, Puoti, Massimo, Rizzardini, Giuliano, Gulminetti, Roberto, Lazzarin, Adriano, Quirino, Tiziano, Sighinolfi, Laura, Viale, Pierluigi, Amaya Tapia, Gerardo, Andrade Villanueva, Jaime, Granados Reyes, Enrique R, Perez Rios, Alma, Santoscoy Gomez, Mario, Den Hollander, Jan, Rijnders, Bart, Hidalgo, José A, Hercilla Vasquez, Luis, Illescas, Luis, Olczak, Anita, Mansinho, Kamal, Correia Pacheco, Patricia Paula, Teófilo, Eugénio, Saraiva da Cunha, Jose, Sarmento e Castro, Rui, Serrão, Rosário, Arbune, Manuela, Jianu, Cristian, Oprea, Anca, Preotescu, Liliana, Prisacariu, Liviu-Jany, Belonosova, Elena, Borodkina, Olga, Chernova, Oxana, Gankina, Natalia, Kizhlo, Svetlana, Kulagin, Valeriy, Kurina, Nadezhda, Nagimova, Firaya, Pokrovsky, Vadim, Ryamova, Elena, Voronin, Evgeny, Yakovlev, Alexey, Kaplan, Richard, Lee, Sun Hee, Kim, Shin-Woo, Kim, Sang-Il, Kim, Woo Joo, Antela Lopez, Antonio, Casado Osorio, Jose L, Castaño Carracedo, Manuel A, De Los Santos Gil, Ignacio, Estrada Perez, Vicente, Falco Ferrer, Vicenç, Force, Luis, Galinda Puerto, Maria Jose, Garcia Deltoro, Miguel, Gatell, Josep M, Goenaga Sanchez, Miguel A, González Cordón, Ana, Knobel, Hernando, Lopez Bernaldo de Quiros, Juan Carlos, Losa Garcia, Juan E, Masia, Mar, Montero-Alsonso, Marta, Ocampo Hermida, Antonio, Pasquau Liaño, Juan, Portilla Sogorb, Joaquin, Pulido Ortega, Federico, Rivera Roman, Antonio, Santos Fernandez, Jose Ramon, Torres Perea, Rafael, Troya Garcia, Jesus, Viciana Fernandez, Pompeyo, Calmy, Alexandra, Hauser, Christoph, Fehr, Jan, Cheng, Shu-Hsing, Ko, Wen-Chien, Lin, Hsi-Hsun, Lu, Po-Liang, Tseng, Yu-Ting, Wang, Ning-Chi, Wong, Wing-Wai, Yang, Chia-Jui, Arduino, Roberto, Benson, Paul, Berhe, Mezgebe, Bredeek, Fritz, Brinson, Cynthia, Campbell, Thomas, Crofoot, Gordon, Cunningham, Douglas, DeJesus, Edwin, Dretler, Robin, Eron, Joseph, Fife, Kenneth, Fichtenbaum, Carl, Flamm, Jason, Goldstein, Deborah, Gupta, Samir, Hagins, Debbie, Hoffman-Terry, Margaret, Jayaweera, Dushyantha, Kinder, Clifford, Klein, Daniel, McDonald, Cheryl, Mills, Anthony, Nahass, Ronald, Osiyemi, Olayemi, Overton, Edgar, Parks, David, Prelutsky, David, Ramgopal, Moti, Schrader, Shannon, Sha, Beverly, Simon, Gary, Sims, James, Skiest, Daniel, Slim, Jihad, Tashima, Karen, Thedinger, Blair, Gazzard, Brian, Fox, Julie, Johnson, Margaret, Kegg, Stephen, Khoo, Saye, Mazhude, Charles, Orkin, Chloe, Schembri, Gabriel, Ustianowski, Andrew, Cahn, Pedro, Madero, Juan Sierra, Arribas, José Ramón, Antinori, Andrea, Ortiz, Roberto, Clarke, Amanda E, Hung, Chien-Ching, Rockstroh, Jürgen K, Girard, Pierre-Marie, Sievers, Jörg, Man, Choy, Currie, Alexander, Underwood, Mark, Tenorio, Allan R, Pappa, Keith, Wynne, Brian, Fettiplace, Anna, Gartland, Martin, Aboud, Michael, Smith, Kimberly

Publikováno v: In The Lancet 12-18 January 2019 393(10167):143-155

Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate

Autor: Gupta, Samir K., Post, Frank A., Arribas, José R., Eron, Joseph J., Wohl, David A., Clarke, Amanda E., Sax, Paul E., Stellbrink, Hans-Jürgen, Esser, Stefan, Pozniak, Anton L., Podzamczer, Daniel, Waters, Laura, Orkin, Chloe, Rockstroh, Jürgen K., Mudrikova, Tatiana, Negredo, Eugenia, Elion, Richard A., Guo, Susan, Zhong, Lijie, Carter, Christoph, Martin, Hal, Brainard, Diana, Sengupta, Devi, Das, Moupali, Jr, Joseph J. Eron

Publikováno v: AIDS (London, England)

Supplemental Digital Content is available in the text
Objective: Compared with tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF) has been associated with improvement in markers of renal dysfunction in individual randomized trials;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db893cb9b9be26bfda5bf5d8cb7438b
https://doi.org/10.1097/qad.0000000000002223

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Brief Report: Randomized, Double-Blind Comparison of Tenofovir Alafenamide (TAF) vs Tenofovir Disoproxil Fumarate (TDF), Each Coformulated With Elvitegravir, Cobicistat, and Emtricitabine (E/C/F) for Initial HIV-1 Treatment: Week 144 Results.

Autor: Arribas JR; Infectious Diseases Unit, Internal Medicine Service, Hospital Universitario La Paz, Madrid, ES; †AIDS Research Consortium of Atlanta, Atlanta, GA; ‡Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA; §Internal Medicine, General Hospital Graz-West, Graz, AT; ‖Tarrant County Infectious Disease Associates, Fort Worth, TX; ¶Division of Infectious Diseases, UNC School of Medicine, Chapel Hill, NC; #Orlando Immunology Center, Orlando, FL; **Claude Nicol Centre, Royal Sussex County Hospital, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom; and ††Departments of Biometrics, Virology, Clinical Operations, and HIV Clinical Research, Gilead Sciences, Inc., Foster City, CA., Thompson M, Sax PE, Haas B, McDonald C, Wohl DA, DeJesus E, Clarke AE, Guo S, Wang H, Callebaut C, Plummer A, Cheng A, Das M, McCallister S

Publikováno v: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2017 Jun 01; Vol. 75 (2), pp. 211-218.