Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Clark Q, Pan"'
Autor:
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan, Rebecca Sendak
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1266-1275 (2019)
Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-deter
Externí odkaz:
https://doaj.org/article/930e74582c1343a88440d28599c59bdc
Publikováno v:
Peptides. 29:479-486
Vasoactive intestinal peptide (VIP) binds to two receptors, VPAC1 and VPAC2. Non-selective VIP antagonists have been shown to inhibit human cancer cell proliferation and reduce tumor growth in mice. Many human cancers over-express VPAC1 but not VPAC2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696d8a75e659bd44739d87a38d256fd
https://doi.org/10.1016/j.peptides.2007.09.003
https://doi.org/10.1016/j.peptides.2007.09.003
Autor:
Huawei, Qiu, Denise M, Honey, Jonathan S, Kingsbury, Anna, Park, Ekaterina, Boudanova, Ronnie R, Wei, Clark Q, Pan, Tim, Edmunds
Publikováno v:
Protein science : a publication of the Protein Society. 24(9)
Recombinant human α-galactosidase A (rhαGal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study, each cysteine residue in rhαGal was replaced with serine to understand the role each cysteine plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b273fce1ca07d860ce8f6259d56d102
https://pubmed.ncbi.nlm.nih.gov/26044846
https://pubmed.ncbi.nlm.nih.gov/26044846
Autor:
Andrea Bell, Stephanie L. Yung, Ling Yang, Joanne M. Buxton, Clark Q. Pan, Thomas H. Claus, Hongxing Chen, James Whelan, Kevin B. Clairmont, Margit MacDougall, Irene Tom
Publikováno v:
Journal of Biological Chemistry. 281:12506-12515
The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316e225f41360b84b459c1ae044ed19f
https://doi.org/10.1074/jbc.m600127200
https://doi.org/10.1074/jbc.m600127200
Publikováno v:
Molecular Biotechnology. 34:165-178
Loss of coagulation factor VIII (FVIII) function results in a bleeding disorder, hemophilia A, which requires FVIII replacement therapy. Owing to its large size and complexity, the expression level of recombinant FVIII is two to three orders of magni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d76a249d16f17fcbccc5f148542df8d
https://doi.org/10.1385/mb:34:2:165
https://doi.org/10.1385/mb:34:2:165
Autor:
Aaron, Moulin, Magali, Mathieu, Catherine, Lawrence, Russell, Bigelow, Mark, Levine, Christine, Hamel, Jean-Piere, Marquette, Josiane, Le Parc, Christophe, Loux, Paul, Ferrari, Cecile, Capdevila, Jacques, Dumas, Bruno, Dumas, Alexey, Rak, Julie, Bird, Huawei, Qiu, Clark Q, Pan, Tim, Edmunds, Ronnie R, Wei
Publikováno v:
Protein science : a publication of the Protein Society. 23(12)
Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known as GC1008, is a pan-TGFβ neutralizing antibody that has been tested clinically for sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a6fb54f6d50902c599a15854fab52c3
https://pubmed.ncbi.nlm.nih.gov/25209176
https://pubmed.ncbi.nlm.nih.gov/25209176
Autor:
Qun Zhou, James E. Stefano, Charlene Manning, Josephine Kyazike, Bo Chen, Diego A. Gianolio, Anna Park, Michelle Busch, Julie Bird, Xiaoyang Zheng, Helene Simonds-Mannes, Jennifer Kim, Rick C. Gregory, Robert J. Miller, William H. Brondyk, Pradeep K. Dhal, Clark Q. Pan
Publikováno v:
Bioconjugate chemistry. 25(3)
Antibody-drug conjugates (ADCs) have been proven clinically to be more effective anti-cancer agents than native antibodies. However, the classical conjugation chemistries to prepare ADCs by targeting primary amines or hinge disulfides have a number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a08436738dfa4010dc9d3c3a502f5a
https://pubmed.ncbi.nlm.nih.gov/24533768
https://pubmed.ncbi.nlm.nih.gov/24533768
Autor:
Tony H. Dodge, Robert A. Lazarus, Dana L. Baker, Clark Q. Pan, Dominick Sinicropi, William S. Prince
Publikováno v:
Journal of Biological Chemistry. 273:18374-18381
The ability of recombinant human DNase I (DNase I) to degrade DNA to lower molecular weight fragments is the basis for its therapeutic use in cystic fibrosis (CF) patients and its potential use as a treatment for systemic lupus erythematosus (SLE). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a10f9835036995e3cc3785dc37e1ec2
https://doi.org/10.1074/jbc.273.29.18374
https://doi.org/10.1074/jbc.273.29.18374
Autor:
Clark Q. Pan, Robert A. Lazarus
Publikováno v:
Journal of Biological Chemistry. 273:11701-11708
Human DNase I, an enzyme used to treat cystic fibrosis patients, has been engineered to more effectively degrade double-stranded DNA to lower molecular weight forms by introducing positively charged amino acids at positions that can interact favorabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a4fe1c4190852316b83ecb0c04cbab3
https://doi.org/10.1074/jbc.273.19.11701
https://doi.org/10.1074/jbc.273.19.11701
Autor:
Sabine Kraft, Barbara Krebs, Bodo Brocks, Michael Schauer, Clark Q. Pan, Stefan Zahn, Sabine Noll
Publikováno v:
Human antibodies. 15(4)
Impaired matrix metalloproteinase 1 (MMP-1) function, as result of the expression of increased levels of tissue inhibitor of metalloproteinase 1 (TIMP-1), plays an important role in the pathopysiolgical mechanism of fibrosis. In a recently performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98205b2f74babaec18b91126656d65c
https://pubmed.ncbi.nlm.nih.gov/17522433
https://pubmed.ncbi.nlm.nih.gov/17522433