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of 3
pro vyhledávání: '"Clark Massick"'
5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles
Autor:
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 9, Pp n/a-n/a (2024)
Abstract 5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair.
Externí odkaz:
https://doaj.org/article/6e5702c671f04d8e9a2013298d18c044
Autor:
Danielle L Michell, Clark Massick, Chase Raby, Ashley Cavnar, Ryan Allen, Rachael Smith, Breanne Gibson, Stephanie Moore-Lotridge, Youmin zhang, Marisol Ramirez, MacRae F Linton, Quanhu Sheng, Jonathan Schoenecker, Kasey C Vickers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Oxidized phospholipids (OxPL) are potent proinflammatory mediators that can trigger toll-like receptor 2 (TLR2) signaling and inflammasome activation in macrophages. Plasminogen (PLG), a key enzyme in the fibrinolytic pathway, has been shown to harbo
Autor:
Danielle L. Michell, Ryan M. Allen, Ashley B. Cavnar, Danielle M. Contreras, Minzhi Yu, Elizabeth M. Semler, Clark Massick, Chase A. Raby, Mark Castleberry, Marisol A. Ramirez, Wanying Zhu, Linda May-Zhang, Anca Ifrim, John Jeffrey Carr, James G. Terry, Anna Schwendeman, Sean S. Davies, Quanhu Sheng, MacRae F. Linton, Kasey C. Vickers
Publikováno v:
The Journal of biological chemistry. 298(6)
Extracellular small RNAs (sRNAs) are abundant in many biofluids, but little is known about their mechanisms of transport and stability in RNase-rich environments. We previously reported that high-density lipoproteins (HDLs) in mice were enriched with