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Autor:
Stefano Tartaggia, Marta Pontini, Ottorino De Lucchi, Riccardo Motterle, Stefano Fogal, Clark Ferrari, Roberto Aureli
Publikováno v:
European Journal of Organic Chemistry. 2016:3162-3165
Enantiopure (R)-3-hydroxy-5-oxohexanoic acid esters have proven to be useful intermediates in the synthesis of the side chain of statins, in view of the recently described preparation of rosuvastatin and other statins through aldol reactions. Herein,
Publikováno v:
European Journal of Organic Chemistry. 2015:4102-4107
The efficient aldol condensation between a derivative of methyl 3-hydroxy-5-oxohexanoate and a pyrimidinecarbaldehyde comprising the core structure of rosuvastatin has been developed as an alternative approach to the classical methods employing ylide