Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Clark, Rutilio H."'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Feb 01. 101(5), 1183-1188.
Externí odkaz:
https://www.jstor.org/stable/3148809
Autor:
Long, Joanna R., Dindot, John L., Zebroski, Henry, Kiihne, Suzanne, Clark, Rutilio H., Campbell, Allison A., Stayton, Patrick S., Drobny, Gary P.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1998 Oct . 95(21), 12083-12087.
Externí odkaz:
https://www.jstor.org/stable/46016
Autor:
Chelsey Bennett, Mcclure Megan J, Georgia D. Tomaras, Michael S. Seaman, Clark Rutilio H, Randal R. Ketchem, J. Alaina Floyd, Kelly E. Seaton, Christine C. Siska, Yan Brodsky, Jeremy M. Shaver, Bryan T. Mayer, Nicole L. Yates, Bruce A. Kerwin, Alison J. Gillespie
Publikováno v:
Journal of Pharmaceutical Sciences
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752f2582d80bda3c1169fc5c9a92aaad
http://europepmc.org/articles/PMC6941225
http://europepmc.org/articles/PMC6941225
Autor:
Amimeur Tileli, Clark Rutilio H, Josh Smith, Danielle Van Citters, Bruce A. Kerwin, Jeremy M. Shaver, Randal R. Ketchem, Christine C. Siska, Smidt Pauline S, Megan Sprague, Dean Pettit, J. Alex Taylor
We demonstrate the use of a Generative Adversarial Network (GAN), trained from a set of over 400,000 light and heavy chain human antibody sequences, to learn the rules of human antibody formation. The resulting model surpasses common in silico techni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13fde634263f9f22e3613107036384e
Publikováno v:
Analytical Biochemistry
The chemical unfolding (denaturation) assay can be used to calculate the change in the Gibbs free energy of unfolding, ΔG, and inflection point of unfolding, to collectively inform on molecule stability. Here, we evaluated methods for calculating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e5085ac74ec673ea6d323af9845bfcd
http://europepmc.org/articles/PMC6226613
http://europepmc.org/articles/PMC6226613
Autor:
Dean Pettit, Kevin J. Whaley, Jane Ennis, Michael T. Trentalange, Richard S. Rogers, Danielle Pace, Alison J. Gillespie, Brittney Livingston, Edith Nalbandian, Chris Crowell, Kelly K. Arthur, Ron Gillespie, Michael H. Pauly, Yan Brodsky, Ken Timmons, James N Thomas, Larry Zeitlin, Smidt Pauline S, Clark Rutilio H
Publikováno v:
mAbs. 8:347-357
From March 2014 through February 2015, the Ebola virus spread rapidly in West Africa, resulting in almost 30,000 infections and approximately 10,000 deaths. With no approved therapeutic options available, an experimental antibody cocktail known as ZM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a826eabda805f303ddee6591711508
https://doi.org/10.1080/19420862.2015.1127492
https://doi.org/10.1080/19420862.2015.1127492
Autor:
Howard Monique L, Esther C. Leng, Nancy Sun, Vladimir I. Razinkov, Haruki Hasegawa, Clark Rutilio H, Janelle Stoops, William C. Fanslow, Zhi Liu, Min Shen, Kannan Gunasekaran, Zhonghua Hu, Martin Pentony, Kathy Manchulenko, Wei Yan, Ian Foltz, Hua Liu
Publikováno v:
Journal of Biological Chemistry. 290:7535-7562
Producing pure and well behaved bispecific antibodies (bsAbs) on a large scale for preclinical and clinical testing is a challenging task. Here, we describe a new strategy for making monovalent bispecific heterodimeric IgG antibodies in mammalian cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68908b92534c719e531a014bc902a6c8
https://doi.org/10.1074/jbc.m114.620260
https://doi.org/10.1074/jbc.m114.620260
Autor:
Kathy Manchulenko, Michael Brown, Cyr Clovis Chua De Imus, Ramil F. Latypov, Clark Rutilio H, Jane Carter, Zien Wilson, Randal R. Ketchem
Publikováno v:
mAbs
Therapeutic antibodies must encompass drug product suitable attributes to be commercially marketed. An undesirable antibody characteristic is the propensity to aggregate. Although there are computational algorithms that predict the propensity of a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98da302b0e99854b390d342d97b0a9d
https://doi.org/10.4161/mabs.36252
https://doi.org/10.4161/mabs.36252
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