Výsledky vyhledávání

Tethered protein display identifies a novel kir3.2 (GIRK2) regulator from protein scaffold libraries

Autor: Minor, Daniel, Bagriantsev, SN, Chatelain, FC, Clark, KA, Alagem, N, Reuveny, E, Minor, DL

Publikováno v: Minor, Daniel; Bagriantsev, SN; Chatelain, FC; Clark, KA; Alagem, N; Reuveny, E; et al.(2014). Tethered protein display identifies a novel kir3.2 (GIRK2) regulator from protein scaffold libraries. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4028p35w

© 2014 American Chemical Society.Use of randomized peptide libraries to evolve molecules with new functions provides a means for developing novel regulators of protein activity. Despite the demonstrated power of such approaches for soluble targets,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d4f36ab0a522f8f9bac4a9ff0c73f2b8
http://www.escholarship.org/uc/item/4028p35w

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Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels

Autor: Lolicato, M, Riegelhaupt, PM, Arrigoni, C, Clark, KA, Minor, DL

Publikováno v: Lolicato, M; Riegelhaupt, PM; Arrigoni, C; Clark, KA; & Minor, DL. (2014). Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels. Neuron, 84(6), 1198-1212. doi: 10.1016/j.neuron.2014.11.017. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/1x63q9v9

© 2014 Elsevier Inc. Mechanical and thermal activation of ion channels iscentral to touch, thermosensation, and pain. TheTRAAK/TREK K2P potassium channel subfamily produces background currents that alter neuronal excitability in response to pressure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::29d3acbdba5dea57270ec28a06187e7c
http://www.escholarship.org/uc/item/1x63q9v9

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A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

Autor: Minor, Daniel, Renslo, Adam, Arkin, Michelle, Bagriantsev, SN, Ang, KH, Gallardo-Godoy, A, Clark, KA, Arkin, MR, Renslo, AR, Minor, DL

Publikováno v: Minor, Daniel; Renslo, Adam; Arkin, Michelle; Bagriantsev, SN; Ang, KH; Gallardo-Godoy, A; et al.(2013). A high-throughput functional screen identifies small molecule regulators of temperature-and mechano-sensitive K2P channels. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5jc0k9qr

K2P (KCNK) potassium channels generate "leak" potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K2Ps lack specific pharmacology. Add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a00fa9123faa6890241244e04e6df793
http://www.escholarship.org/uc/item/5jc0k9qr

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Metabolic and thermal stimuli control K 2P 2.1 (TREK-1) through modular sensory and gating domains

Autor: Minor, Daniel, Bagriantsev, SN, Clark, KA, Minor, DL

Publikováno v: Minor, Daniel; Bagriantsev, SN; Clark, KA; & Minor, DL. (2012). Metabolic and thermal stimuli control K 2P 2.1 (TREK-1) through modular sensory and gating domains. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9mj328x8

K 2P 2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that responds to external pH, GPCR-mediated phosphorylation signals, and temperature through the action of distinct sensors within the channel. How the various intracellular and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8f8eada0b7afaba7b26cd5cc670ef6f5
http://www.escholarship.org/uc/item/9mj328x8

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Dissertation/ Thesis

Extensions to the OCLUST Algorithm

Autor: Clark, Katharine M

OCLUST is a clustering algorithm that trims outliers in Gaussian mixture models. While mixtures of multivariate Gaussian distributions are a useful way to model heterogeneity in data, it is not always an appropriate assumption that the data arise fro

Externí odkaz: http://hdl.handle.net/11375/30113

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Akademický článek

Decrease in Stroke Diagnoses During the COVID-19 Pandemic: Where Did All Our Stroke Patients Go?

Autor: Dula, Adrienne Nicole, Gealogo Brown, Gretchel, Aggarwal, Aarushi, Clark, Kal L

Publikováno v: JMIR Aging, Vol 3, Iss 2, p e21608 (2020)

Despite the evidence suggesting a high rate of cerebrovascular complications in patients with SARS-CoV-2, reports have indicated decreasing rates of new ischemic stroke diagnoses during the COVID-19 pandemic. The observed decrease in emergency depart

Externí odkaz: https://doaj.org/article/deed495ed0a341f68e64a6dfbfc475ad

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